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Disease
Synovitis
Late-stage therapeutic developmentEmerging researchRising momentum
3
Publications
15
Clinical trials
2
Related conditions
1
Associated genes
2024
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Innate Immunity and Synovitis: Key Players in Osteoarthritis Progression.
Research2024-11-11International journal of molecular sciences
The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis.
Research2022-05-19Frontiers in immunology
Macrophage: A Potential Target on Cartilage Regeneration.
Research2020-02-11Frontiers in immunology
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Major trial resultsHigh impact
Results posted2026-05-04
Upcoming trial readoutHigh impact
Results expected Q4 20262026-05-27
Clinical MilestonesViewHide
Results posted
- 2026-05-04A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study of ABSK021 to Assess the Efficacy and Safety in Patients With Tenosynovial Giant Cell TumorResults posted
- 2026-03-20A Phase 3, Randomized, Placebo-controlled, Double-blind Study of Vimseltinib to Assess the Efficacy and Safety in Patients With Tenosynovial Giant Cell Tumor (MOTION)Results posted
Results expected
- 2026-05-27Dronabinol for the Treatment of Postoperative Pain After Arthroscopic Surgery: a Pilot Randomized TrialResults expected Q4 2026
Recently completed
- 2026-08-28A Multicenter, Randomized, Double-blind, Placebo-controlled, Proof of Concept Trial to Investigate the Efficacy and Safety of Intra-articular 4P004 in Subjects With Knee Synovitis and OsteoarthritisPrimary completion
- 2026-08-01Injection After Arthroscopic Partial MeniscectomyPrimary completion
- 2026-07-01Role of Methotrexate in Ultrasound Proven Synovitis in Patients With Knee Osteoarthritis : A Randomized Controlled TrialPrimary completion
- 2026-04-15Efficacy of Intra-Articular Bevacizumab in Preventing Recurrent Hemarthrosis in Hemophilia Patients With Chronic Synovitis: A Pre- and Post-Design StudyCompleted
- 2025-11-19Efficacy and Safety Study of the Etoricoxib/Betamethasone Combination Compared With Etoricoxib for the Treatment of Patients Diagnosed With an Acute Episode of Bursitis, Tendinitis, or Synovitis of the Shoulder, Elbow, Knee, or AnkleCompleted
Activity timeline8
- 2026-08-28ClinicalA Multicenter, Randomized, Double-blind, Placebo-controlled, Proof of Concept Trial to Investigate the Efficacy and Safety of Intra-articular 4P004 in Subjects With Knee Synovitis and OsteoarthritisPrimary completion
- 2026-08-01ClinicalInjection After Arthroscopic Partial MeniscectomyPrimary completion
- 2026-07-01ClinicalRole of Methotrexate in Ultrasound Proven Synovitis in Patients With Knee Osteoarthritis : A Randomized Controlled TrialPrimary completion
- 2026-05-27ClinicalDronabinol for the Treatment of Postoperative Pain After Arthroscopic Surgery: a Pilot Randomized TrialResults expected Q4 2026
- 2026-05-04ClinicalA Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study of ABSK021 to Assess the Efficacy and Safety in Patients With Tenosynovial Giant Cell TumorResults posted
- 2026-04-15ClinicalEfficacy of Intra-Articular Bevacizumab in Preventing Recurrent Hemarthrosis in Hemophilia Patients With Chronic Synovitis: A Pre- and Post-Design StudyCompleted
- 2026-03-20ClinicalA Phase 3, Randomized, Placebo-controlled, Double-blind Study of Vimseltinib to Assess the Efficacy and Safety in Patients With Tenosynovial Giant Cell Tumor (MOTION)Results posted
- 2025-11-19ClinicalEfficacy and Safety Study of the Etoricoxib/Betamethasone Combination Compared With Etoricoxib for the Treatment of Patients Diagnosed With an Acute Episode of Bursitis, Tendinitis, or Synovitis of the Shoulder, Elbow, Knee, or AnkleCompleted
Clinical trials
The current development programme across all trial phases.
Clinical programme
15
6
7
6
Late-stage studies
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
20202024
Most influential
Major themes7
- Synovitis2
- Arthritis, Rheumatoid1
- Autoimmune Diseases1
- Disease Progression1
- Immunity, Innate1
- Osteoarthritis1
- Respiratory Distress Syndrome1
Leading journals2
- Frontiers in immunology2
- International journal of molecular sciences1
Leading researchers8
- Amano MT1
- Arciola CR1
- Bueno DF1
- Campitiello R1
- Costantini S1
- Cutolo M1
- Dolzani P1
- Fernandes TL1
Affiliations (unnormalised)6
- Alma Mater Studiorum University of Bologna1
- Center for Cartilage Repair and Sports Medicine1
- Hospital for Special Surgery1
- Hospital Sírio-Libanês1
- Institute of Orthopedics and Traumatology1
- Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Inflammation of the SYNOVIAL MEMBRANE.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.