Tachycardia, Ventricular
Recent clinical, regulatory, research and industry developments relating to this disease.
A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial with recent milestones (1 completed or reporting results).
Clinical MilestonesViewHide
- 2026-06-26ClinicalEffectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia PacingResults posted
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Defibrillators, Implantable2
- Arrhythmias, Cardiac1
- Cardiac Pacing, Artificial1
- Consensus1
- Desmoplakins1
- Electrocardiography1
- Magnetic Resonance Imaging1
- Pacemaker, Artificial1
Leading journals5
- Circulation1
- Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology1
- European heart journal1
- JAMA1
- The New England journal of medicine1
Leading researchers8
- Schulze-Bahr E2
- Tondo C2
- Wilde A2
- Abrams DJ1
- Ader F1
- Antz M1
- Antzelevitch C1
- Biagini E1
Affiliations (unnormalised)6
- University of Milan2
- Acibadem City Clinic Tokuda Hospital1
- Amsterdam UMC Location University of Amsterdam1
- APHP Sorbonne Université1
- Azienda Sanitaria Universitaria Giuliano Isontina1
- Brown University School of Medicine and Rhode Island Hospital1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Ventricular tachycardia is an abnormally rapid rhythm arising from the ventricles, usually at more than 150 beats per minute. It originates below the bundle of His and may present with wide QRS complexes that are uniform or polymorphic, with atrioventricular dissociation in some cases.
The grounding supports ventricular tachycardia as a rhythm generated within the ventricle by either autonomic impulse formation or reentrant impulse conduction. It is also described as occurring in association with Brugada syndrome, where ventricular tachycardia/fibrillation can underlie sudden arrhythmic death.
The core mechanism is abnormal impulse generation or reentry within ventricular tissue below the bundle of His. This produces a rapid ventricular rhythm that can be paroxysmal or nonparoxysmal, with wide QRS complexes and sometimes dissociation between atrial and ventricular activity.
The supplied material supports Brugada syndrome as a risk context for ventricular tachycardia/fibrillation and sudden arrhythmic death. In that syndrome, a spontaneously appearing Brugada ECG is associated with high risk, and the ECG pattern may be unmasked or modulated by sodium channel blockers, febrile states, vagotonic agents, alpha-adrenergic agonists, beta-adrenergic blockers, and certain antidepressants.
The grounding does not provide a general treatment standard for ventricular tachycardia itself. It only supports that ventricular tachycardia/fibrillation in Brugada syndrome is a major arrhythmic risk, without specifying a treatment modality or drug class for ventricular tachycardia overall.
AI-generated summary grounded in MeSH and 1 peer-reviewed source. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.