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Disease

Tibial Fractures

Late-stage therapeutic developmentEmerging research
MeSHTibial Fractures
1
Publications
8
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial
Results expected Q1 20272026-07-07
Upcoming trial readoutHigh impact
Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
Results expected Q4 20262026-05-26
Clinical Milestones3View
Results expected 2
Other updates 1
Activity timeline3

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net -1)

The current development programme across all trial phases.

Clinical programme
8
All trials
3
Active
6
Late-stage
3
Completed
Late-stage studies

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

Phase 3 · Recruiting · Major Extremity Trauma Research Consortium

Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial

Phase 3 · Recruiting · Wake Forest University Health Sciences

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

Phase 4 · Recruiting · Wake Forest University Health Sciences

A Prospective, Randomized, Controlled, Stratified Study of InductOs in Subjects With Open Diaphyseal Tibia Fractures Treated With Reamed Locked Intramedullary Nail Fixation

Phase 4 · Completed · Wyeth is now a wholly owned subsidiary of Pfizer

The Effect of Intra-articular Local Anesthetic Injection and Hematoma Aspiration on Pain and Narcotic Analgesia Use Following Tibial Plateau Fractures

Phase 4 · Terminated · Loyola University

Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures

Phase 4 · Completed · University of Puerto Rico

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes4
  • Ganglia, Spinal1
  • Hyperalgesia1
  • Postoperative Pain1
  • Vagus Nerve Stimulation1
Leading journals1
  • Pain1
Leading researchers8
  • Baht GS1
  • Caceres AI1
  • Chen J1
  • Huang M1
  • Jordt SE1
  • Nackley AG1
  • Sokoloff J1
  • Terrando N1
Affiliations (unnormalised)5
  • Center for Translational Pain Medicine1
  • Duke Molecular Physiology Institute1
  • Duke University1
  • Duke University Medical Center1
  • Duke University School of Medicine1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Fractures of the TIBIA.

Identifiers
MeSHTibial Fractures
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.