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Disease

Tobacco Use Disorder

Late-stage therapeutic developmentEmerging research
MeSHTobacco Use Disorder
1
Publications
18
Clinical trials
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 6 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Beta-Adrenergic Modulation of Drug Cue Reactivity: Neural and Behavioral Mechanisms
Results expected Q1 20272026-04-28
Upcoming trial readoutHigh impact
Randomized Controlled Trial of Varenicline to Treat Tobacco and Cannabis Co-Use (RECLAIM)
Results expected Q3 20282026-04-03
Clinical Milestones7View
Results expected 5
Recently completed 1
Activity timeline7

Clinical trials

13 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
13
Late-stage
6
Completed
Late-stage studies

Randomized Controlled Trial of Varenicline to Treat Tobacco and Cannabis Co-Use (RECLAIM)

Phase 3 · Recruiting · Medical University of South Carolina

Beta-Adrenergic Modulation of Drug Cue Reactivity: Neural and Behavioral Mechanisms

Phase 4 · Recruiting · University of Oklahoma

Integrating Transcranial Magnetic Stimulation as a Treatment for Nicotine Dependence in the Clinic: A Pragmatic, Hybrid Effectiveness-Implementation Trial

Phase 4 · Recruiting · Centre for Addiction and Mental Health

Cytisine: Testing Its Potential as a Therapeutic Strategy for Smoking Cessation Among People With Concurrent Alcohol Use Disorder

Phase 4 · Completed · Centre for Addiction and Mental Health

A Prospective Trial of Varenicline and Incentives for Tobacco Cessation in Adults

Phase 4 · Completed · Medical University of South Carolina

Achieving Smoking Cessation Milestones in Opioid Treatment Patients: a Randomized 2 x 2 Factorial Trial of Directly Observed and Long-term Varenicline

Phase 4 · Completed · Albert Einstein College of Medicine
Recruiting

Randomized Controlled Trial of Varenicline to Treat Tobacco and Cannabis Co-Use (RECLAIM)

Phase 3 · Recruiting · Medical University of South Carolina

Beta-Adrenergic Modulation of Drug Cue Reactivity: Neural and Behavioral Mechanisms

Phase 4 · Recruiting · University of Oklahoma

Integrating Transcranial Magnetic Stimulation as a Treatment for Nicotine Dependence in the Clinic: A Pragmatic, Hybrid Effectiveness-Implementation Trial

Phase 4 · Recruiting · Centre for Addiction and Mental Health

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Phase 2 · Recruiting · VA Office of Research and Development

5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

Phase 2 · Recruiting · Johns Hopkins University

Evaluating the Efficacy of Cannabidiol for Reducing Cigarette Use

Phase 2 · Recruiting · University of California, Los Angeles
Recently completed

Cytisine: Testing Its Potential as a Therapeutic Strategy for Smoking Cessation Among People With Concurrent Alcohol Use Disorder

Phase 4 · Completed · Centre for Addiction and Mental Health

A Prospective Trial of Varenicline and Incentives for Tobacco Cessation in Adults

Phase 4 · Completed · Medical University of South Carolina

Achieving Smoking Cessation Milestones in Opioid Treatment Patients: a Randomized 2 x 2 Factorial Trial of Directly Observed and Long-term Varenicline

Phase 4 · Completed · Albert Einstein College of Medicine

Personalized Dosing of Nicotine Replacement for Smoking Cessation: An Effectiveness Randomized Placebo-controlled Trial

Phase 4 · Completed · Centre for Addiction and Mental Health

Pharmacogenetics, Emotional Reactivity and Smoking

Phase 2/3 · Completed · M.D. Anderson Cancer Center

Optimizing Tobacco Dependence Treatment in the Emergency Department

Phase 3 · Completed · Yale University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes2
  • Betacoronavirus1
  • Risk Reduction Behavior1
Leading journals1
  • Pulmonary medicine1
Leading researchers4
  • Balogun SA1
  • Ojo AS1
  • Ojo OS1
  • Williams OT1
Affiliations (unnormalised)2
  • Obafemi Awolowo University Teaching Hospital Complex1
  • St. George's University School of Medicine1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.

Identifiers
MeSHTobacco Use Disorder
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.