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Disease

Total joint arthroplasty

Late-stage therapeutic development

Also known as TJA, joint replacement, joint replacement surgery, total joint replacement surgery.

24

Clinical trials

12

Associated genes

2

Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate

Key developments

5 clinical trials expected to report results, the earliest in Q2 2027.

Upcoming Milestones

Major developments

Major trial resultsHigh impact

An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty

Results posted2026-06-05

Upcoming trial readoutHigh impact

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Results expected Q3 20282026-04-28

Clinical Milestones10View all 10

Results posted 1

2026-06-05An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee ArthroplastyResults posted

Results expected 5

2026-04-28Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control TrialResults expected Q3 2028
2026-03-05Effect of Perioperative Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty for Osteoarthritis, in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of ComplicationsResults expected Q3 2032
2026-02-23A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle ArthroplastyResults expected Q3 2029
2025-12-11Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee ArthroplastyResults expected Q3 2028
2025-11-24Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled TrialResults expected Q2 2027

Recently completed 3

Other updates 1

2025-12-01A Double-Blind Randomized Comparison Trial of Postoperative Pain in Patients Undergoing Total Shoulder Arthroplasty Who Receive Interscalene Blocks With or Without Liposomal Bupivacaine (PoPTSAWoW Trial)Terminated

+2 more in the activity timeline below

Activity timeline10

2026-06-05ClinicalAn Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee ArthroplastyResults posted
2026-04-30ClinicalComparison of Perioperative Intravenous vs Periarticular Dexamethasone vs no Steroid Supplementation in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Primary Total Knee Arthroplasty for Knee Osteoarthritis - A Randomized Controlled Trial Clinical Study ProtocolPrimary completion
2026-04-28ClinicalEvaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control TrialResults expected Q3 2028
2026-03-05ClinicalEffect of Perioperative Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty for Osteoarthritis, in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of ComplicationsResults expected Q3 2032
2026-02-23ClinicalA Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle ArthroplastyResults expected Q3 2029
2025-12-11ClinicalReducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee ArthroplastyResults expected Q3 2028
2025-12-01ClinicalA Double-Blind Randomized Comparison Trial of Postoperative Pain in Patients Undergoing Total Shoulder Arthroplasty Who Receive Interscalene Blocks With or Without Liposomal Bupivacaine (PoPTSAWoW Trial)Terminated
2025-11-26ClinicalEffects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty - a Randomized, Controlled, Blinded StudyCompleted
2025-11-24ClinicalAnalgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled TrialResults expected Q2 2027
2025-09-11ClinicalA Randomized Controlled Trial of Ultrasound Guided Knee Genicular Nerve Block and Anterior Femoral Cutaneous Nerve Block for Primary Total Knee ArthroplastyCompleted

Clinical trials

15 sponsors · 3 new · 2 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme

24

All trials

6

Active

18

Late-stage

6

Completed

Late-stage studies

Comparison of Perioperative Intravenous vs Periarticular Dexamethasone vs no Steroid Supplementation in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Primary Total Knee Arthroplasty for Knee Osteoarthritis - A Randomized Controlled Trial Clinical Study Protocol

Phase 4 · Recruiting · Christian Candrian

Effect of Perioperative Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty for Osteoarthritis, in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications

Phase 4 · Recruiting · Christian Candrian

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Phase 3 · Recruiting · University of Alabama at Birmingham

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Phase 4 · Recruiting · Vanderbilt University Medical Center

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

Phase 3 · Recruiting · Emory University

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

Phase 3 · Recruiting · The University of Hong Kong

Recruiting

Comparison of Perioperative Intravenous vs Periarticular Dexamethasone vs no Steroid Supplementation in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Primary Total Knee Arthroplasty for Knee Osteoarthritis - A Randomized Controlled Trial Clinical Study Protocol

Phase 4 · Recruiting · Christian Candrian

Effect of Perioperative Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty for Osteoarthritis, in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications

Phase 4 · Recruiting · Christian Candrian

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Phase 3 · Recruiting · University of Alabama at Birmingham

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Phase 4 · Recruiting · Vanderbilt University Medical Center

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

Phase 3 · Recruiting · Emory University

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

Phase 3 · Recruiting · The University of Hong Kong

Recently completed

Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty - a Randomized, Controlled, Blinded Study

Phase 4 · Completed · Regionshospitalet Silkeborg

A Randomized Controlled Trial of Ultrasound Guided Knee Genicular Nerve Block and Anterior Femoral Cutaneous Nerve Block for Primary Total Knee Arthroplasty

Phase 4 · Completed · Hospital for Special Surgery, New York

Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty

Phase 4 · Completed · Prisma Health-Upstate

A Prospective, Triple-Blind, Randomized Controlled Trial Evaluating Duloxetine on Post-Operative Outcomes Following Primary Total Knee Arthroplasty in Patients With and Without Central Sensitization

Phase 4 · Completed · Rush University Medical Center

An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty

Phase 4 · Completed · University of Wisconsin, Madison

The Efficacy of Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty: a Randomized, Double-blinded, Non-inferiority Study

Phase 4 · Completed · Rhode Island Hospital

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COLGALT20.44 RFLNA0.41 TCP110.36 TACC30.33 SIRAL20.31 NACA20.31 P3H20.31 MGP0.30 NT5DC10.30 WFIKKN20.29 MDFI0.28 NEK40.28

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Integrin alpha-2via ITGA20.16 Tumor necrosis factor receptor superfamily member 9via TNFRSF90.15

Reference

Authoritative identity, definition & identifiers.

Synonyms

TJA, joint replacement, joint replacement surgery, total joint replacement surgery

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Related entities are derived from literature co-mention (studied together) — associative, not causal.