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Disease

Total joint arthroplasty

Late-stage therapeutic development

Also known as TJA, joint replacement, joint replacement surgery, total joint replacement surgery.

24

Clinical trials

12

Associated genes

2

Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate

Key developments

6 clinical trials expected to report results, the earliest in Q2 2027.
12 industry developments reported.

Upcoming Milestones

Major developments

Upcoming trial readoutHigh impact

Early Wear Patterns Detected With CT RSA in Vitamin E-infused Liner Versus Conventional Highly Crosslinked Liner After Total Hip Arthroplasty With Dual Mobility Cups: a Randomized Controlled Trial

Results expected Q4 20332026-10-09

Major trial resultsHigh impact

An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty

Results posted2026-06-05

Reimbursement decisionWorth watching

CMS expands Comprehensive Care for Joint Replacement model

Reimbursement · Healio Orthopedics2026-10-06

Clinical Milestones9View all 9

Results posted 1

2026-06-05An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee ArthroplastyResults posted

Results expected 5

2026-10-09Early Wear Patterns Detected With CT RSA in Vitamin E-infused Liner Versus Conventional Highly Crosslinked Liner After Total Hip Arthroplasty With Dual Mobility Cups: a Randomized Controlled TrialResults expected Q4 2033
2026-07-30A Randomized, Placebo-controlled, Double-blind Trial of Suzetrigine in Total Hip ArthroplastyResults expected Q4 2027
2026-06-22A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee ReplacementResults expected Q2 2028
2026-04-28Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control TrialResults expected Q3 2028
2026-02-23A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle ArthroplastyResults expected Q3 2029

Recently completed 1

2025-11-26Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty - a Randomized, Controlled, Blinded StudyCompleted

Other updates 1

2025-12-01A Double-Blind Randomized Comparison Trial of Postoperative Pain in Patients Undergoing Total Shoulder Arthroplasty Who Receive Interscalene Blocks With or Without Liposomal Bupivacaine (PoPTSAWoW Trial)Terminated

+1 more in the activity timeline below

Industry & Market12View all 12

2026-10-06CMS expands Comprehensive Care for Joint Replacement modelReimbursement · Healio Orthopedics
2026-09-01Dual Eligibility Status Is Associated With Lower Surgeon Reimbursement Despite Greater Patient Complexity in Primary Total Joint ArthroplastyReimbursement · The Journal of Arthroplasty
2026-09-30Epic Fail: Robots Don't Improve Joint Replacement Outcomes in Big U.K. StudiesResearch news · MedPage Today
2026-09-09The “Borderline” Bone Density Result That May Not Be So Benign After Joint ReplacementIndustry · Orthopedics This Week
2026-09-20More Tech-Savvy Than You Think: Digital Proficiency Among Total Joint Arthroplasty PatientsIndustry · The Journal of Arthroplasty

+7 more in the activity timeline below

Activity timeline21

2026-10-09ClinicalEarly Wear Patterns Detected With CT RSA in Vitamin E-infused Liner Versus Conventional Highly Crosslinked Liner After Total Hip Arthroplasty With Dual Mobility Cups: a Randomized Controlled TrialResults expected Q4 2033
2026-10-06IndustryCMS expands Comprehensive Care for Joint Replacement modelReimbursement · Healio Orthopedics
2026-09-30IndustryEpic Fail: Robots Don't Improve Joint Replacement Outcomes in Big U.K. StudiesResearch news · MedPage Today
2026-09-20IndustryMore Tech-Savvy Than You Think: Digital Proficiency Among Total Joint Arthroplasty PatientsIndustry · The Journal of Arthroplasty
2026-09-09IndustryThe “Borderline” Bone Density Result That May Not Be So Benign After Joint ReplacementIndustry · Orthopedics This Week
2026-09-01IndustryDual Eligibility Status Is Associated With Lower Surgeon Reimbursement Despite Greater Patient Complexity in Primary Total Joint ArthroplastyReimbursement · The Journal of Arthroplasty
2026-08-24IndustryIncidence and Risk Factors for Periprosthetic Joint Infection in Patients Undergoing Primary Total Joint Arthroplasty Who have a History of Surgically Treated Periprosthetic Joint Infection in Another JointIndustry · The Journal of Arthroplasty
2026-08-24IndustryOutpatient and Early Discharge Revision Total Joint Arthroplasty: A Systematic Review and Pooled Quantitative AnalysisIndustry · The Journal of Arthroplasty
2026-08-19IndustryIncreased Risk of Periprosthetic Femoral Fracture with Cementless Collared Metadiaphyseal-Filling Stems Compared to Cemented Fixation for Femoral Neck Fractures in Patients Aged 65 Years or Older: An American Joint Replacement Registry AnalysisIndustry · The Journal of Arthroplasty
2026-07-30ClinicalA Randomized, Placebo-controlled, Double-blind Trial of Suzetrigine in Total Hip ArthroplastyResults expected Q4 2027

Clinical trials

15 sponsors · 5 new · 1 completed in the last 12 months (net +4)

The current development programme across all trial phases.

Clinical programme

24

All trials

6

Active

18

Late-stage

6

Completed

Late-stage studies

Early Wear Patterns Detected With CT RSA in Vitamin E-infused Liner Versus Conventional Highly Crosslinked Liner After Total Hip Arthroplasty With Dual Mobility Cups: a Randomized Controlled Trial

Phase 4 · Recruiting · Uppsala University

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Phase 3 · Recruiting · University of Alabama at Birmingham

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

Phase 3 · Recruiting · Emory University

A Randomized, Placebo-controlled, Double-blind Trial of Suzetrigine in Total Hip Arthroplasty

Phase 3 · Recruiting · Hospital for Special Surgery, New York

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

Phase 3 · Recruiting · The University of Hong Kong

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Phase 4 · Recruiting · AdventHealth

Recruiting

Early Wear Patterns Detected With CT RSA in Vitamin E-infused Liner Versus Conventional Highly Crosslinked Liner After Total Hip Arthroplasty With Dual Mobility Cups: a Randomized Controlled Trial

Phase 4 · Recruiting · Uppsala University

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Phase 3 · Recruiting · University of Alabama at Birmingham

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

Phase 3 · Recruiting · Emory University

A Randomized, Placebo-controlled, Double-blind Trial of Suzetrigine in Total Hip Arthroplasty

Phase 3 · Recruiting · Hospital for Special Surgery, New York

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

Phase 3 · Recruiting · The University of Hong Kong

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Phase 4 · Recruiting · AdventHealth

Recently completed

Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty - a Randomized, Controlled, Blinded Study

Phase 4 · Completed · Regionshospitalet Silkeborg

A Randomized Controlled Trial of Ultrasound Guided Knee Genicular Nerve Block and Anterior Femoral Cutaneous Nerve Block for Primary Total Knee Arthroplasty

Phase 4 · Completed · Hospital for Special Surgery, New York

Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty

Phase 4 · Completed · Prisma Health-Upstate

A Prospective, Triple-Blind, Randomized Controlled Trial Evaluating Duloxetine on Post-Operative Outcomes Following Primary Total Knee Arthroplasty in Patients With and Without Central Sensitization

Phase 4 · Completed · Rush University Medical Center

An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty

Phase 4 · Completed · University of Wisconsin, Madison

The Efficacy of Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty: a Randomized, Double-blinded, Non-inferiority Study

Phase 4 · Completed · Rhode Island Hospital

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COLGALT20.44 RFLNA0.41 TCP110.36 TACC30.33 SIRAL20.31 NACA20.31 P3H20.31 MGP0.30 NT5DC10.30 WFIKKN20.29 MDFI0.28 NEK40.28

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Integrin alpha-2via ITGA20.16 Tumor necrosis factor receptor superfamily member 9via TNFRSF90.15

Reference

Authoritative identity, definition & identifiers.

Synonyms

TJA, joint replacement, joint replacement surgery, total joint replacement surgery

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Related entities are derived from literature co-mention (studied together) — associative, not causal.