Tuberculosis, Meningeal
Recent clinical, regulatory, research and industry developments relating to this disease.
Recent advances in understanding the human host immune response in tuberculous meningitis.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q4 2027.
Clinical MilestonesViewHide
- 2026-06-01ClinicalDIRECT: Doxycycline Adjunctive Therapy to Reduce Excess Mortality and Complications From Central Nervous System Tuberculosis - Phase II Randomized Clinical TrialResults expected Q4 2027
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes3
- MicroRNAs1
- Mycobacterium tuberculosis1
- Tuberculosis, Meningeal1
Leading journals1
- Frontiers in immunology1
Leading researchers3
- Barnacle JR1
- Davis AG1
- Wilkinson RJ1
Affiliations (unnormalised)3
- Centre for Infectious Diseases Research in Africa1
- Imperial College1
- The Francis Crick Institute1
Reference
Authoritative identity, definition & identifiers.
A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.