LCE4A

Gene

late cornified envelope 4A

HGNCHGNC:16613 EnsemblENSG00000187170 NCBI Gene199834

Locus: gene with protein productLocation: 1q21.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSPRL4A · LEP8

View full nomenclature history (3)

Previous symbolsSPRL4A

Alias symbolsLEP8

Previous namessmall proline rich-like (epidermal differentiation complex) 4A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dermatitis, Atopic

Candidemia

Tuberculosis, Meningeal

Multiple Sclerosis, Chronic Progressive

Candidiasis

Candidiasis, Invasive

Panniculitis

Retinal Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Late cornified envelope proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.