Back to discover
Drug

Acetazolamide

Approved · FDA
ClassCarbonic anhydrase I inhibitorEmerging researchLate-stage developmentRising momentum
Also known as Diamox, Acetazolamid, Acetazolamida, Acétazolamide+5 more

Diamox, Acetazolamid, Acetazolamida, Acétazolamide, 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, 5-acetamido-1,3,4-thiadiazole-2-sulfonamide, 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide, AcetaZOLAMIDE Sodium, Acetazolamidum.

RxNorm167ChEMBLCHEMBL20ATCS01EC01UNIIO3FX965V0I
3
Research papers
26
Active clinical trials
4
Protein targets
12
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly

Clinical trial2026-07-31Primary completion · ClinicalTrials.gov

Label change: ACETAZOLAMIDE (ANDA040904)

Regulatory2026-07-14FDA

A Randomized Controlled Trial of Acetazolamide for Patients With Treatment Resistant Schizophrenia

Clinical trial2026-07-07Results expected Q4 2027 · ClinicalTrials.gov

Label change: ACETAZOLAMIDE (ANDA040089)

Regulatory2026-07-01FDA

Targeting Chemoreceptor Control of Breathing During Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing

Clinical trial2026-07-01Results expected Q4 2026 · ClinicalTrials.gov

Impact of Acetazolamide on Central Sleep Apnea Patients Receiving Medication for Opioid Use Disorder

Clinical trial2026-06-25Results expected Q1 2028 · ClinicalTrials.gov

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude: a Randomized Cross-over Controlled Trial

Clinical trial2026-06-15Primary completion · ClinicalTrials.gov

Label change: ACETAZOLAMIDE (ANDA202693)

Regulatory2026-06-05FDA

Label change: ACETAZOLAMIDE (ANDA202693)

Regulatory2024-07-26FDA

Treatment with GLP-1 receptor agonists is associated with significant weight loss and favorable headache outcomes in idiopathic intracranial hypertension.

Research2023-07-18The journal of headache and pain

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.

Research2022-08-27The New England journal of medicine

Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial.

Research2014-04-01JAMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Acetazolamide
Aliases & brands
DiamoxAcetazolamidAcetazolamidaAcétazolamide2-acetylamino-1,3,4-thiadiazole-5-sulfonamide5-acetamido-1,3,4-thiadiazole-2-sulfonamide5-acetylamino-1,3,4-thiadiazole-2-sulfonamideAcetaZOLAMIDE SodiumAcetazolamidum
RxNorm CUI
167
ChEMBL ID
CHEMBL20
ATC codes
S01EC01
UNII
O3FX965V0I
Primary mechanism
Carbonic anhydrase I inhibitor
Regulatory jurisdictions
fda

Pharmacology & targets

4 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Carbonic anhydrase 1
CA1 · P00915
INHIBITORCarbonic anhydrase I inhibitor
Carbonic anhydrase 2
CA2 · P00918
INHIBITORCarbonic anhydrase II inhibitor
Carbonic anhydrase 12
CA12 · O43570
INHIBITORCarbonic anhydrase XII inhibitor
Carbonic anhydrase 4
CA4 · P22748
INHIBITORCarbonic anhydrase IV inhibitor

Regulatory timeline

12 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
1995-02-28
Latest approval
2014-12-19
Authorities
FDA
Total events
12
fdaU.S. Food and Drug Administration· 12 events
2026-07-14Label change
Label change: ACETAZOLAMIDE (ANDA040904)
Evidence ↗
2026-07-01Label change
Label change: ACETAZOLAMIDE (ANDA040089)
Evidence ↗
2026-06-05Label change
Label change: ACETAZOLAMIDE (ANDA202693)
Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

131 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
131
registered trials across all phases
LATEST COMPLETION 2026
26
Active studies
19
Recruiting
84
Late-stage (III+)
69
Completed
36
Discontinued
PHASE DISTRIBUTIONn = 131
Early Phase 14Phase 110Phase 1 / 28Phase 225Phase 2 / 38Phase 310Phase 448Phase N / A18

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload - A Randomized Clinical Trial

RecruitingPH IVJohannes Grandn=9392027

TACTIC-HF: Thiazide or Acetazolamide Combination Versus Intravenous Furosemide in Ambulatory Worsening Heart Failure - a Randomized Crossover Trial

Not yet recruitingPH IVLucrecia Maria Burgosn=602027

Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly

RecruitingPH IVVA Office of Research and Developmentn=1002026

HighCycle Study: Effect of Acetazolamide on Plasma Volume During Acute Exposure to High Altitude in Women and Men

RecruitingPH IVCentre d'Expertise sur l'Altitude EXALTn=2702025

Acetazolamide Per os for Decompensation of Heart Failure

RecruitingPH IVSamara State Medical Universityn=4002025

Recent completions

Trials that read out recently, adding to the completed evidence base.

Double-blind Randomized Acetazolamide Trial in Normal Pressure Hydrocephalus

CompletedPH IIUppsala University Hospitaln=502026

The Effect of Acetazolamide on the Severity of REM Obstructive Sleep Apnea

CompletedPH I/IIBrigham and Women's Hospitaln=112025

Managing Opioid Related Sleep Apnea With Acetazolamide

CompletedPH IIUniversity of California, San Diegon=392025

HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men: A Randomized, Placebo-Controlled, Double-Blind Parallel Trial

CompletedPH IVUniversity of Zurichn=3032025

HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women. A Randomized, Placebo-Controlled, Double-Blind Parallel Trial.

CompletedPH IVUniversity of Zurichn=3032025

HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men. A Randomized, Placebo-Controlled, Double-Blind Parallel Trial.

CompletedPH IVUniversity of Zurichn=3032025

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20142023
Major research themes7
Acetazolamide1Carbonic Anhydrase Inhibitors1Diet, Sodium-Restricted1Diuretics1Heart Failure1Pseudotumor Cerebri1Water-Electrolyte Imbalance1
Journals, researchers & institutions
Top journals
  • JAMA1
  • The journal of headache and pain1
  • The New England journal of medicine1
Leading researchers
  • Blouard P1
  • Bruckers L1
  • Bsteh G1
  • Chenot F1
  • Corbett JJ1
  • Damman K1
  • Dauw J1
  • Derthoo D1
Leading institutions
free-text, unnormalised
  • Comprehensive Center for Clinical Neurosciences1
  • Hasselt University1
  • Medical University of Vienna1
  • National Eye Institute1
  • Roosevelt Hospital1
  • University of California1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.