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Drug

Acetylcholine

In clinical development
Emerging researchEarly-to-mid developmentCooling momentum
Also known as ACh, Miochol, O-Acetylcholine, Acetylcholine Chloride+1 more

ACh, Miochol, O-Acetylcholine, Acetylcholine Chloride, Choline acetate.

RxNorm194ChEMBLCHEMBL667ATCS01EB09UNIIN9YNS0M02X
8
Research papers
6
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Correcting congenital myasthenia-associated acetylcholine receptor defects

Industry2026-07-01Nature News

Hot Flashes and Neurovascular Function in Women

Clinical trial2026-06-12Results expected Q4 2026 · ClinicalTrials.gov

Early Neurovascular Adaptations in Aging Women

Clinical trial2025-11-26Results expected Q2 2027 · ClinicalTrials.gov

Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation

Clinical trial2025-08-12Primary completion · ClinicalTrials.gov

Protective Mechanisms of Prenatal Aspirin Therapy on Maternal Vascular Dysfunction Following Preeclampsia

Clinical trial2025-05-31Results expected Q1 2027 · ClinicalTrials.gov

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Clinical trial2025-05-13Results expected Q2 2027 · ClinicalTrials.gov

Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Clinical trial2025-05-13Results expected Q4 2026 · ClinicalTrials.gov

Investigation of Endothelium-dependent Vasodilation in Human Gingiva Depending on Serum Estrogen Level

Clinical trial2024-12-31Primary completion · ClinicalTrials.gov

New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase.

Research2024-04-12Journal of cellular physiology

Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.

Research2023-08-30The Journal of neuroscience : the official journal of the Society for Neuroscience

Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning.

Research2023-07-06Molecular psychiatry

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.

Research2022-08-18Nature communications

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Acetylcholine
Aliases & brands
AChMiocholO-AcetylcholineAcetylcholine ChlorideCholine acetate
RxNorm CUI
194
ChEMBL ID
CHEMBL667
ATC codes
S01EB09
UNII
N9YNS0M02X

Clinical trials

30 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
30
registered trials across all phases
LATEST COMPLETION 2021
6
Active studies
6
Recruiting
9
Late-stage (III+)
12
Completed
12
Discontinued
PHASE DISTRIBUTIONn = 30
Early Phase 18Phase 16Phase 1 / 22Phase 25Phase N / A9

Recent completions

Trials that read out recently, adding to the completed evidence base.

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

CompletedPH IColorado State Universityn=92021

Investigation of the Endothel Dependent and Independent Vasodilatation in Human Gingiva: Comparison of the Effect of NO and ACH

CompletedN/ASemmelweis Universityn=242021

Study to Assess the Pharmacodynamic Effects of Repeated Oral Doses of SAR247799 on Endothelial Function in Male and Female Patients With Type 2 Diabetes Mellitus

CompletedPH ISanofin=542018

Niacin Therapy to Improve Endothelial Function in Sickle Cell Disease

CompletedPH IINational Heart, Lung, and Blood Institute (NHLBI)n=302015

Bevacizumab and Endothelium Dependent Vasodilation

CompletedN/ARadboud University Medical Centern=242011

Investigating the Interaction of Apelin and Systemic Angiotensin II Peripheral Resistance Vessels and Systemic Haemodynamics in Vivo in Man

CompletedN/AUniversity of Edinburghn=122010

Research activity

8 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20162024
Most influential

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex.

Nature communications · 2016 · 689 cites

Role of Cholinergic Signaling in Alzheimer's Disease.

Molecules (Basel, Switzerland) · 2022 · 431 cites

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.

Nature communications · 2022 · 317 cites

Alzheimer's Disease Pharmacotherapy in Relation to Cholinergic System Involvement.

Biomolecules · 2019 · 159 cites

Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022 · 150 cites

New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase.

Journal of cellular physiology · 2024 · 23 cites
Recent papers

New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase.

Journal of cellular physiology · 2024 · 23 cites

Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning.

Molecular psychiatry · 2023 · 10 cites

Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023 · 7 cites

Role of Cholinergic Signaling in Alzheimer's Disease.

Molecules (Basel, Switzerland) · 2022 · 431 cites

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.

Nature communications · 2022 · 317 cites

Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022 · 150 cites
Major research themes8
Acetylcholine2Alzheimer Disease2Acetylcholinesterase1Amyloidosis1Association Learning1Butyrylcholinesterase1Carbohydrate Metabolism1Cognition Disorders1
Journals, researchers & institutions
Top journals
  • Nature communications2
  • Biomolecules1
  • Journal of cellular physiology1
  • Molecular psychiatry1
  • Molecules (Basel, Switzerland)1
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology1
Leading researchers
  • Ababei DC1
  • Allard S1
  • Ando M1
  • Arnsten AFT1
  • Baiza-Gutman LA1
  • Berens P1
  • Beschea Chiriac SI1
  • Bild V1
Leading institutions
free-text, unnormalised
  • Baylor College of Medicine1
  • College of Medicine1
  • Columbia University1
  • Computational Bio Big-Data Open Innovation Laboratory1
  • Experimental Center of Pathogen Biology1
  • Fuzhou Medical College1

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas
Alzheimer's Disease3

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Amylopectin

Studied across 2 of the same disease areas as Acetylcholine in the shared literature.

2 shared diseases1 shared paper
Ornithine

Studied across 2 of the same disease areas as Acetylcholine in the shared literature.

2 shared diseases1 shared paper
Norepinephrine

Studied across the same disease area as Acetylcholine in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials