Drug

Norepinephrine

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as (-)-arterenol, (-)-noradrenaline, (R)-(-)-norepinephrine, (R)-noradrenaline+15 more

(-)-arterenol, (-)-noradrenaline, (R)-(-)-norepinephrine, (R)-noradrenaline, (R)-norepinephrine, Arterenol, L-Norepinephrine, L-noradrenaline, Levophed, Nor-adrenaline, Noradrenalin, Noradrenaline, Norepinefrina, (-)-norepinephrine, Norépinéphrine, (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, Levophed Bitartrate, Norepinephrine Bitartrate, Norepinephrinum.

RxNorm7512 ChEMBLCHEMBL1437 ATCC01CA03UNIIX4W3ENH1CV

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery, a Randomized Open Label Trial

Clinical trial2026-08-02Primary completion · ClinicalTrials.gov

A Single Center, Pilot Study of Induced Hypertension for Minimizing Infarct Progression in Patients With Acute Large-vessel Occlusion Ischemic Stroke Undergoing Endovascular Therapy

Clinical trial2026-08-01Suspended · ClinicalTrials.gov

Synthesis of methyldopa-copper nanoparticles with laccase mimics activity for colorimetric detection of norepinephrine

Industry2026-07-17Nature — Environmental Sciences

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Comparison of the Efficacy and Safety of Dopamine, Norepinephrine and Epinephrine in the Treatment of Pulmonary Hypertensive Crisis Under Hemodynamic Monitoring

Clinical trial2026-06-25Results expected Q4 2028 · ClinicalTrials.gov

Comparison of Norepinephrine Versus Phenylephrine Infusion for Prevention of Hypotension Due to Subarachnoid Block in Elderly Patients Undergoing Orthopedic Hip Surgery:A Prospective Randomized Trial

Clinical trial2026-06-23Results expected Q1 2027 · ClinicalTrials.gov

Hot Flashes and Neurovascular Function in Women

Clinical trial2026-06-12Results expected Q4 2026 · ClinicalTrials.gov

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion.

Research2024-08-13Nature communications

Impact of norepinephrine on immunity and oxidative metabolism in sepsis.

Research2023-11-07Frontiers in immunology

Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation.

Research2023-10-17Journal of neuroinflammation

Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.

Research2023-07-24Proceedings of the National Academy of Sciences of the United States of America

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Norepinephrine

Aliases & brands

(-)-arterenol(-)-noradrenaline(R)-(-)-norepinephrine(R)-noradrenaline(R)-norepinephrineArterenolL-NorepinephrineL-noradrenalineLevophedNor-adrenalineNoradrenalinNoradrenalineNorepinefrina(-)-norepinephrineNorépinéphrine(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediolLevophed BitartrateNorepinephrine BitartrateNorepinephrinum

RxNorm CUI

7512

ChEMBL ID

CHEMBL1437

ATC codes

C01CA03

UNII

X4W3ENH1CV

Clinical trials

170 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

170

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

151

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 170

Early Phase 17Phase 12Phase 1 / 23Phase 27Phase 2 / 36Phase 325Phase 451Phase N / A69

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Mechanistic Assessment of Norepinephrine TheRapy vs. Angiotensin-II in Septic Shock (MANTRA) Grant Submission- Dysfunctional Renin-Angiotensin System in Septic Shock

Not yet recruitingPH IVWake Forest University Health Sciencesn=782028

Norepinephrine vs Phenylephrine as the First-line Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-cardiac Surgery

RecruitingPH IVKey trialUniversity of California, San Franciscon=18,0002028

Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension: A Pilot Trial

RecruitingPH IVUniversity of California, Davisn=302028

Tight Perioperative Blood Pressure Management to Reduce Serious Cardiovascular, Renal, and Cognitive Complications: The GUARDIAN Trial (Vasopressor Sub-study Comparing Phenylephrine and Norepinephrine)

Enrolling by invitationPH IVKey trialThe University of Texas Health Science Center, Houstonn=6,2542027

Comparison of Norepinephrine Versus Phenylephrine Infusion for Prevention of Hypotension Due to Subarachnoid Block in Elderly Patients Undergoing Orthopedic Hip Surgery:A Prospective Randomized Trial

RecruitingPH IVSohag Universityn=622027

Recent completions

Trials that read out recently, adding to the completed evidence base.

Prophylactic vs Rescue Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension on Neonatal Outcomes During Cesarean Section: A Multicenter, Single-blind, Crossover, Factorial Cluster Trial

CompletedN/AGeneral Hospital of Ningxia Medical Universityn=7002026

Effect of Ephedrine and Norepinephrine on Fetal Acidosis During Cesarean Section Under Spinal Anesthesia: A Prospective, Randomized Controlled Trial

CompletedPH IVmehmet özkılıçn=1022025

Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction

CompletedPH IIICentre Hospitalier Universitaire, Amiensn=5002025

Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor

CompletedN/AFirst Affiliated Hospital of Zhejiang Universityn=5842025

Comparison of Continuous Norepinephrine and Phenylephrine Infusion for Preventing Hypotension During Low-Dose Spinal Anesthesia in Cesarean Delivery: A Randomized Controlled Trial

CompletedPH IVTam Anh Research Instituten=1002025

Determination of the 90% Effective Dose of the Initial Bolus of Norepinephrine in Elective Cesarean Section: An Up-Down Study

CompletedPH IVPontificia Universidad Catolica de Chilen=602025

Research activity

9 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20002024

Most influential

Decision making, the P3, and the locus coeruleus-norepinephrine system.

Psychological bulletin · 2005 · 1,172 cites

Gender differences in depression. Critical review.

The British journal of psychiatry : the journal of mental science · 2000 · 1,163 cites

Central modulation of pain.

The Journal of clinical investigation · 2010 · 781 cites

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex.

Nature communications · 2016 · 689 cites

Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.

The Behavioral and brain sciences · 2016 · 457 cites

Impact of norepinephrine on immunity and oxidative metabolism in sepsis.

Frontiers in immunology · 2023 · 33 cites

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Epinephrine

Studied across 2 of the same disease areas as Norepinephrine in the shared literature.

2 shared diseases1 shared paper

Insulin

Studied across 2 of the same disease areas as Norepinephrine in the shared literature.

2 shared diseases1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials