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Drug

Adenosine

In clinical development
ClassAdenosine receptor agonistActively researchedLate-stage developmentSteady momentum
Also known as 6-Amino-9-beta-D-ribofuranosyl-9H-purine, 9-beta-D-Ribofuranosidoadenine, 9-beta-D-Ribofuranosyl-9H-purin-6-amine, Ade-Rib+14 more

6-Amino-9-beta-D-ribofuranosyl-9H-purine, 9-beta-D-Ribofuranosidoadenine, 9-beta-D-Ribofuranosyl-9H-purin-6-amine, Ade-Rib, Adenin riboside, Adenine Deoxyribonucleoside, Adenocard, Adenogesic, Adenoscan, Ado, My-O-Den, beta-D-Adenosine, Adenosin, Adenosina, Adénosine, (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Adenosine Phosphate, Adenosinum.

RxNorm296ChEMBLCHEMBL477ATCC01EB10UNIIK72T3FS567
30
Research papers
7
Active clinical trials
4
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

Clinical trial2026-07-07Results expected Q1 2027 · ClinicalTrials.gov

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Clinical trial2026-06-23Results expected Q4 2027 · ClinicalTrials.gov

COMparison of Adenosine Versus Diltiazem FOR Supraventricular Tachycardia in the ED (COMFORT-ED) - Pilot Trial

Clinical trial2026-05-28Results expected Q3 2027 · ClinicalTrials.gov

Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction An Open-label, Single Center Trial

Clinical trial2025-12-01Withdrawn · ClinicalTrials.gov

Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19 (The ARCTIC Trial)

Clinical trial2025-12-01Withdrawn · ClinicalTrials.gov

Adenosine Receptors in Neuroinflammation and Neurodegeneration.

Research2025-10-11Cells

Intravenous Adenosine Versus Diltiazem After Failed Modified Valsalva for Hemodynamically Stable ANVRT in the Emergency Department

Clinical trial2025-08-30Completed · ClinicalTrials.gov

A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Clinical trial2025-06-30Primary completion · ClinicalTrials.gov

Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

Clinical trial2025-06-27Results expected Q4 2026 · ClinicalTrials.gov

REDIportal: toward an integrated view of the A-to-I editing.

Research2025-01-01Nucleic acids research

Advances in A-to-I RNA editing in cancer.

Research2024-12-27Molecular cancer

Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling.

Research2024-11-28Nature communications

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Adenosine
Aliases & brands
6-Amino-9-beta-D-ribofuranosyl-9H-purine9-beta-D-Ribofuranosidoadenine9-beta-D-Ribofuranosyl-9H-purin-6-amineAde-RibAdenin ribosideAdenine DeoxyribonucleosideAdenocardAdenogesicAdenoscanAdoMy-O-Denbeta-D-AdenosineAdenosinAdenosinaAdénosine(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolAdenosine PhosphateAdenosinum
RxNorm CUI
296
ChEMBL ID
CHEMBL477
ATC codes
C01EB10
UNII
K72T3FS567
Primary mechanism
Adenosine receptor agonist

Pharmacology & targets

4 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Adenosine receptor A1
ADORA1 · P30542
AGONISTAdenosine receptor agonist
Adenosine receptor A2b
ADORA2B · P29275
AGONISTAdenosine receptor agonist
Adenosine receptor A3
ADORA3 · P0DMS8
AGONISTAdenosine receptor agonist
Adenosine receptor A2a
ADORA2A · P29274
AGONISTAdenosine receptor agonist

Clinical trials

59 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
59
registered trials across all phases
LATEST COMPLETION 2025
7
Active studies
6
Recruiting
40
Late-stage (III+)
36
Completed
16
Discontinued
PHASE DISTRIBUTIONn = 59
Early Phase 13Phase 15Phase 1 / 23Phase 28Phase 2 / 32Phase 314Phase 49Phase N / A15

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome. A Multinational, Multicentre, Registry-based, Open-label, Randomized Controlled Trial.

RecruitingPH IVKey trialVastra Gotaland Regionn=1,0002028

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

RecruitingPH IVWeill Medical College of Cornell Universityn=1002027

COMparison of Adenosine Versus Diltiazem FOR Supraventricular Tachycardia in the ED (COMFORT-ED) - Pilot Trial

RecruitingPH IVAnne E. Zepeskin=202027

Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

RecruitingPH IVRegion Skanen=1802026

Intravenous Adenosine Versus Diltiazem After Failed Modified Valsalva for Hemodynamically Stable ANVRT in the Emergency Department

CompletedPH IVHaseki Training and Research Hospitaln=1402025

Recent completions

Trials that read out recently, adding to the completed evidence base.

Intravenous Adenosine Versus Diltiazem After Failed Modified Valsalva for Hemodynamically Stable ANVRT in the Emergency Department

CompletedPH IVHaseki Training and Research Hospitaln=1402025

Adenosine Contrast CorrELations in Evaluating RevAscularizaTION

CompletedPH IVDuke Universityn=2012023

To Investigate the Headache Induction and the Cerebral Hemodynamic Changes After Infusion of Adenosine in Healthy Volunteers and Migraine Patient

CompletedN/ADanish Headache Centern=182021

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

CompletedPH IColorado State Universityn=92021

Efficacy of Intracoronary Adrenaline and Its Comparison With Intracoronary Adenosine in the Treatment of No-Reflow in Normotensive Patients With Acute Coronary Syndrome

CompletedPH IVNational Institute of Cardiovascular Diseases, Pakistann=2012021

A Randomised Controlled Trial of the Standard Versus a Simplified Adenosine Administration Method in the Treatment of Adult Patients With Supra- Ventricular Tachycardia (SVT)

CompletedPH IIIUniversity of Pretorian=302020

Research activity

30 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192025
Recent papers

REDIportal: toward an integrated view of the A-to-I editing.

Nucleic acids research · 2025 · 16 cites

Adenosine Receptors in Neuroinflammation and Neurodegeneration.

Cells · 2025 · 2 cites

Adenosine and Cortical Plasticity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025 · 1 cites

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice.

Nature communications · 2024 · 50 cites

WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury.

International journal of surgery (London, England) · 2024 · 41 cites

Programmable RNA N<sup>6</sup>-methyladenosine editing with CRISPR/dCas13a in plants.

Plant biotechnology journal · 2024 · 19 cites
Major research themes8
Adenosine9Neoplasms4Neuronal Plasticity3Astrocytes2Gene Expression Regulation, Neoplastic2Neurodegenerative Diseases2Neurons2Receptors, Purinergic P12
Journals, researchers & institutions
Top journals
  • Molecular cancer5
  • Nature communications5
  • Journal of hematology & oncology4
  • Cells2
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1
  • Biomolecules1
Leading researchers
  • Zhang X4
  • Li X3
  • Wang J3
  • Zhang Y3
  • Chen Y2
  • Liu X2
  • Wang X2
  • Wang Y2
Leading institutions
free-text, unnormalised
  • School of Medicine2
  • School of Public Health2
  • State Key Laboratory of Oncology in South China2
  • Xiangya Hospital2
  • Acupuncture and Tuina School1
  • Affiliated Foshan Maternity and Child Healthcare Hospital1

Related diseases

5 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Atezolizumab

Studied across 9 of the same disease areas as Adenosine in the shared literature.

9 shared diseases1 shared paper
Cyclic AMP

Studied across 3 of the same disease areas as Adenosine in the shared literature.

3 shared diseases1 shared paper
Tazemetostat

Studied across 3 of the same disease areas as Adenosine in the shared literature.

3 shared diseases1 shared paper
Inosine

Studied across the same disease area as Adenosine in the shared literature.

1 shared disease2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials