Drug

Inosine

In clinical development

Emerging researchLate-stage development

Also known as Hypoxanthosine, INO, beta-Inosine, hypoxanthine D-riboside+3 more

Hypoxanthosine, INO, beta-Inosine, hypoxanthine D-riboside, Inosin, Inosina, Inosinum.

RxNorm1483575 ChEMBLCHEMBL1556 ATCD06BB05 ATCG01AX02 ATCS01XA10UNII5A614L51CT

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy: A Phase I Drug Pilot Research Plan

Clinical trial2026-04-23Results expected Q3 2028 · ClinicalTrials.gov

A Phase Ib Trial of Combined Febuxostat and Inosine Therapy in Patients With Parkinson's Disease

Clinical trial2026-03-31Primary completion · ClinicalTrials.gov

REDIportal: toward an integrated view of the A-to-I editing.

Research2025-01-01Nucleic acids research

a Pilot Study to Explore the Efficacy of Inosine Reversing Chemo Resistance in Triple Negative Breast Cancer

Clinical trial2025-01-01Completed · ClinicalTrials.gov

Advances in A-to-I RNA editing in cancer.

Research2024-12-27Molecular cancer

Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes

Clinical trial2023-02-16Results posted · ClinicalTrials.gov

Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)

Clinical trial2021-02-18Results posted · ClinicalTrials.gov

Administration of Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation Protocol: A Pilot Trial

Clinical trial2020-08-19Results posted · ClinicalTrials.gov

A Randomized, Double-blind, Placebo-controlled Trial of Urate-elevating Inosine Treatment to Slow Clinical Decline in Early Parkinson's Disease

Clinical trial2020-07-28Results posted · ClinicalTrials.gov

Phase 3, Multicenter, Randomized, Double-blind, Placebo Controlled Withdrawal Study of Pulmonary Arterial Hypertension(PAH) Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled Nitric Oxide (INO)

Clinical trial2020-06-01Withdrawn · ClinicalTrials.gov

A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)

Clinical trial2017-11-06Results posted · ClinicalTrials.gov

A Phase 1, Open-label, Randomized, Two-period, Two-treatment, Crossover Study to Evaluate the Effects of Food on the Pharmacokinetics of Urate After a Single Dose of Inosine in Healthy Male Subjects

Clinical trial2017-03-29Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Inosine

Aliases & brands

HypoxanthosineINObeta-Inosinehypoxanthine D-ribosideInosinInosinaInosinum

RxNorm CUI

1483575

ChEMBL ID

CHEMBL1556

ATC codes

D06BB05G01AX02S01XA10

UNII

5A614L51CT

Clinical trials

14 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 14

Phase 14Phase 24Phase 33Phase 41Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes

CompletedPH IVDuke Universityn=5192021

WithdrawnPH IIIBellerophon Pulse Technologies2020

A Randomized, Double-blind, Placebo-controlled Trial of Urate-elevating Inosine Treatment to Slow Clinical Decline in Early Parkinson's Disease

CompletedPH IIIMichael Alan Schwarzschildn=2982019

Inhaled NO for the Prevention of Chronic Lung Disease

CompletedPH IIIUniversity of Colorado, Denvern=7932007

Recent completions

Trials that read out recently, adding to the completed evidence base.

a Pilot Study to Explore the Efficacy of Inosine Reversing Chemo Resistance in Triple Negative Breast Cancer

CompletedPH IIFudan Universityn=102025

Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes

CompletedPH IVDuke Universityn=5192021

Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)

CompletedPH IIMassachusetts General Hospitaln=482020

A Randomized, Double-blind, Placebo-controlled Trial of Urate-elevating Inosine Treatment to Slow Clinical Decline in Early Parkinson's Disease

CompletedPH IIIMichael Alan Schwarzschildn=2982019

Administration of Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation Protocol: A Pilot Trial

CompletedN/AUniversity of Oklahoman=332017

A Phase 1, Open-label, Randomized, Two-period, Two-treatment, Crossover Study to Evaluate the Effects of Food on the Pharmacokinetics of Urate After a Single Dose of Inosine in Healthy Male Subjects

CompletedPH IMichael Alan Schwarzschildn=182016

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20242025

Most influential

Advances in A-to-I RNA editing in cancer.

Molecular cancer · 2024 · 17 cites

REDIportal: toward an integrated view of the A-to-I editing.

Nucleic acids research · 2025 · 16 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Adenosine

Studied across the same disease area as Inosine in the shared literature.

1 shared disease2 shared papers

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials