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Drug

Amitriptyline

In clinical development
Emerging researchLate-stage development
Also known as Amitriptyline-Chlordiazepoxide, Elavil, Endep, Limbitrol+10 more

Amitriptyline-Chlordiazepoxide, Elavil, Endep, Limbitrol, Perphenazine-Amitriptyline, Triavil, Vanatrip, Amitriptilina, Amitriptylin, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene, 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene, Amitriptyline Hydrochloride, Amitriptylinum.

RxNorm704ChEMBLCHEMBL629ATCN06AA09UNII1806D8D52K
2
Research papers
9
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Comparative Outcomes of Migraine Preventives and Anti-CGRP Therapies for Tinnitus in Patients With Migraine: A Randomized Active-Comparator Controlled Trial (COMPACT-PM)

Clinical trial2026-06-17Results expected Q3 2031 · ClinicalTrials.gov

Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release

Clinical trial2026-06-10Results expected Q2 2033 · ClinicalTrials.gov

Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease: A Multicenter Randomized Placebo-Controlled Trial

Clinical trial2026-06-05Results expected Q4 2029 · ClinicalTrials.gov

Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine

Clinical trial2026-03-11Withdrawn · ClinicalTrials.gov

Cognitive Behavioral Therapy Via Telehealth + Amitriptyline Compared to Cognitive Behavioral Therapy Via Telehealth: Pediatric Migraine Prevention (Responding With Evidence and Access for Childhood Headaches)

Clinical trial2026-03-06Results expected Q3 2027 · ClinicalTrials.gov

Pilot Studies Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Clinical trial2026-02-18Results expected Q4 2028 · ClinicalTrials.gov

A Randomized, Double-blind, Placebo Controlled, Dose Escalation Pilot Study Evaluating the Efficacy of Two Doses of Duloxetine and Amitriptyline in Interstitial Lung Disease-related Cough

Clinical trial2026-01-21Results expected Q4 2026 · ClinicalTrials.gov

A Randomized, Double-blind, Placebo-controlled, Dose-escalation Study Evaluating the Efficacy of Two Doses of Duloxetine & Amitriptyline in Subjects With Refractory Chronic Cough

Clinical trial2026-01-21Results expected Q4 2026 · ClinicalTrials.gov

A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients

Clinical trial2026-01-12Results posted · ClinicalTrials.gov

Distinct Mechanisms of Cognitive Behavioral Therapy Effects in Youth With Migraine & Dissecting Neural Mechanisms Supporting Mind and Body Approaches to Pain Reduction in Youth With Migraine

Clinical trial2025-06-30Completed · ClinicalTrials.gov

Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.

Research2014-04-14Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.

Research2010-03-29The Journal of urology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Amitriptyline
Aliases & brands
Amitriptyline-ChlordiazepoxideElavilEndepLimbitrolPerphenazine-AmitriptylineTriavilVanatripAmitriptilinaAmitriptylin3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cyclohepteneAmitriptyline HydrochlorideAmitriptylinum
RxNorm CUI
704
ChEMBL ID
CHEMBL629
ATC codes
N06AA09
UNII
1806D8D52K

Clinical trials

71 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
71
registered trials across all phases
LATEST COMPLETION 2025
9
Active studies
9
Recruiting
50
Late-stage (III+)
36
Completed
26
Discontinued
PHASE DISTRIBUTIONn = 71
Early Phase 11Phase 14Phase 1 / 21Phase 215Phase 2 / 36Phase 314Phase 417Phase N / A13

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Comparative Outcomes of Migraine Preventives and Anti-CGRP Therapies for Tinnitus in Patients With Migraine: A Randomized Active-Comparator Controlled Trial (COMPACT-PM)

Not yet recruitingPH IVStanford Universityn=1202031

Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care: a Pragmatic Clinical Trial [PREMI Study]

Not yet recruitingPH IVFundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurinan=4602026

Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis: An Open Label Randomized Clinical Trial

Unknown statusPH IVDr. Reaz Mahmudn=1502023

A Comparison of the Efficacy of 5% Lidocaine Anesthetic to Provide SPGB Vs. Elavil for the Treatment of Transformed Migraine

TerminatedPH IVRutgers, The State University of New Jerseyn=102020

Effects of Amitriptyline on Central Pain Processing in Healthy Volunteers Depending on CYP Pharmacogenetics

CompletedPH IVInsel Gruppe AG, University Hospital Bernn=482019

Recent completions

Trials that read out recently, adding to the completed evidence base.

Distinct Mechanisms of Cognitive Behavioral Therapy Effects in Youth With Migraine & Dissecting Neural Mechanisms Supporting Mind and Body Approaches to Pain Reduction in Youth With Migraine

CompletedPH IIChildren's Hospital Medical Center, Cincinnatin=1322025

Phase II Randomized Controlled Study Aiming to Evaluate the Interest of Qutenza in Patients With Head and Neck Cancer in Remission and With Sequelae Neuropathic Pain.

CompletedPH IIInstitut Claudius Regaudn=132025

Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch

CompletedN/AAalborg Universityn=302024

Comparison of Amitriptyline and Nerve Blocks (GON and SON) in Patients With Migraine

CompletedN/ADr. Lutfi Kirdar Kartal Training and Research Hospitaln=572023

Physiology of GERD and Treatment Response

CompletedN/AUniversity of California, Davisn=72021

Effects of Amitriptyline on Central Pain Processing in Healthy Volunteers Depending on CYP Pharmacogenetics

CompletedPH IVInsel Gruppe AG, University Hospital Bernn=482019

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20102014
Major research themes1
Survivors1
Journals, researchers & institutions
Top journals
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology1
  • The Journal of urology1
Leading researchers
  • Bak K1
  • Bleeker J1
  • Burks DA1
  • Cavaletti G1
  • Cen L1
  • Chai TC1
  • Chauhan C1
  • Dworkin RH1
Leading institutions
free-text, unnormalised
  • Columbia University Medical Center1
  • Yale University1

Related drugs

5 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Baclofen

Studied across 3 of the same disease areas as Amitriptyline in the shared literature.

3 shared diseases1 shared paper
Duloxetine Hydrochloride

Studied across 3 of the same disease areas as Amitriptyline in the shared literature.

3 shared diseases1 shared paper
Gabapentin

Studied across 3 of the same disease areas as Amitriptyline in the shared literature.

3 shared diseases1 shared paper
gamma-Aminobutyric Acid

Studied across 3 of the same disease areas as Amitriptyline in the shared literature.

3 shared diseases1 shared paper
Ketamine

Studied across 3 of the same disease areas as Amitriptyline in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials