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Drug

Atorvastatin

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as Atorvaliq, Caduet, Lipitor, Liptruzet+4 more

Atorvaliq, Caduet, Lipitor, Liptruzet, atorvastatina, atorvastatine, Atorvastatin Calcium, atorvastatinum.

RxNorm83367ChEMBLCHEMBL1487ATCC10AA05UNIIA0JWA85V8F
10
Research papers
23
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Treatment of Bile Acid Diarrhoea With Atorvastatin (BASTA): A Randomised, Double-Blind, Placebo-Controlled, Crossover, Investigator-Initiated Trial

Clinical trial2026-07-09Results expected Q4 2026 · ClinicalTrials.gov

Phase II Interventional Study Using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

Clinical trial2026-06-05Results expected Q3 2028 · ClinicalTrials.gov

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)

Clinical trial2026-06-04Results expected Q4 2026 · ClinicalTrials.gov

A Phase 1, Open-Label, Two-Period Fixed Sequence Study to Evaluate the Effects of a Single Oral Dose of Ulonivirine (MK-8507) on the Single-Dose Pharmacokinetics of Atorvastatin and Metformin in Healthy Adult Participants

Clinical trial2026-06-03Completed · ClinicalTrials.gov

Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia Patients: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study

Clinical trial2026-06-02Results expected Q4 2027 · ClinicalTrials.gov

Alirocumab for Stabilisation of Symptomatic Vulnerable Carotid Plaque: A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial With High-Resolution Vessel-Wall MRI and Clinical Endpoints

Clinical trial2026-05-14Results expected Q1 2030 · ClinicalTrials.gov

A Phase III Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer

Clinical trial2026-05-06Results expected Q1 2042 · ClinicalTrials.gov

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial.

Research2015-01-09The lancet. HIV

A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes.

Research2014-11-22Pediatric diabetes

Study design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial.

Research2012-08-01Cardiovascular drugs and therapy

Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.

Research2012-03-28Neurology

Atorvastatin lowers LDL cholesterol in hyperlipidaemia — High confidence reached

Research2008-09-01High confidence reached · Forefront confidence

Evidence confidence

1 claim

How strongly the incorporated evidence supports specific clinical claims about this treatment. A confidence figure is a current summary of evidence strength, not a permanent verdict.

Lowers LDL cholesterol in hyperlipidaemia
76%High confidence
Uncertainty ±5%Evidence coverage: SubstantialUpdated 1 May 2026

Confidence is moderated by well-powered no-effect evidence and limited publication incorporation, despite broad trial support.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Atorvastatin
Aliases & brands
AtorvaliqCaduetLipitorLiptruzetatorvastatinaatorvastatineAtorvastatin Calciumatorvastatinum
RxNorm CUI
83367
ChEMBL ID
CHEMBL1487
ATC codes
C10AA05
UNII
A0JWA85V8F

Clinical trials

188 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
188
registered trials across all phases
LATEST COMPLETION 2026
23
Active studies
20
Recruiting
121
Late-stage (III+)
114
Completed
51
Discontinued
PHASE DISTRIBUTIONn = 188
Early Phase 12Phase 131Phase 1 / 21Phase 233Phase 2 / 34Phase 349Phase 449Phase N / A19

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Statins to Prevent Immune Checkpoint Inhibitor-induced PRogression of AtherosLerosis

Not yet recruitingPH IVErasmus Medical Centern=1402030

Non-commercial Clinical Trial of Statins CAncer Preventive and Pleiotropic TherApy IN Smokers With Chronic Obstructive Pulmonary Disease (COPD)

Active, not recruitingPH IVMedical University of Bialystokn=4602027

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)

RecruitingPH IVKey trialDuke Universityn=20,0002026

Treatment of Bile Acid Diarrhoea With Atorvastatin (BASTA): A Randomised, Double-Blind, Placebo-Controlled, Crossover, Investigator-Initiated Trial

RecruitingPH IVAsger Lund, MDn=202026

High Dose of Atorvastatin for Preventing Cerebral Vascular Wall Damage in Patients Undergoing Mechanical Thrombectomy

Not yet recruitingPH IVZhongda Hospitaln=1622026

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Phase 1, Open-Label, Two-Period Fixed Sequence Study to Evaluate the Effects of a Single Oral Dose of Ulonivirine (MK-8507) on the Single-Dose Pharmacokinetics of Atorvastatin and Metformin in Healthy Adult Participants

CompletedPH IMerck Sharp & Dohme LLCn=122026

Atorvastatin Therapy in the Treatment of Dyslipidemia in Children With Steroid Sensitive Nephrotic Syndrome

CompletedPH IVNational Institute of Kidney Disease and Urology (NIKDU)n=1002025

Repurposing Atorvastatin in Patients With Ulcerative Colitis Treated With Mesalamine by Modulation of mTOR/NLRP3 Pathway.

CompletedPH IITanta Universityn=542025

A Pilot Study of Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy

CompletedPH IUniversity of Utahn=92025

An Open-label, One-sequence Cross-over, Single-centre Trial, Investigating the Influence of CagriSema on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Atorvastatin in Participants With Overweight or Obesity

CompletedPH INovo Nordisk A/Sn=342024

A Phase 1, Open Label, Fixed Sequence Study to Evaluate the Effect of ECC5004 on the Single Dose Pharmacokinetics of Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants

CompletedPH IEccogenen=482024

Research activity

10 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042015
Most influential

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine · 2004 · 3,251 cites

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial.

The lancet. HIV · 2015 · 197 cites

Atorvastatin for prevention of atrial fibrillation recurrence following pulmonary vein isolation: a double-blind, placebo-controlled, randomized trial.

Heart rhythm · 2012 · 42 cites

Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.

Neurology · 2012 · 32 cites

Safety and efficacy of ezetimibe added to atorvastatin versus up titration of atorvastatin to 40 mg in Patients > or = 65 years of age (from the ZETia in the ELDerly [ZETELD] study).

The American journal of cardiology · 2010 · 32 cites

A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes.

Pediatric diabetes · 2015 · 31 cites
Recent papers

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial.

The lancet. HIV · 2015 · 197 cites

A randomized, double blind, placebo-controlled pilot trial of the safety and efficacy of atorvastatin in children with elevated low-density lipoprotein cholesterol (LDL-C) and type 1 diabetes.

Pediatric diabetes · 2015 · 31 cites

Atorvastatin for prevention of atrial fibrillation recurrence following pulmonary vein isolation: a double-blind, placebo-controlled, randomized trial.

Heart rhythm · 2012 · 42 cites

Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.

Neurology · 2012 · 32 cites

Study design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial.

Cardiovascular drugs and therapy · 2012 · 13 cites

Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment.

Microcirculation (New York, N.Y. : 1994) · 2011 · 20 cites
Major research themes5
Catheter Ablation1Hyperinsulinism1Insulin Resistance1Magnetic Resonance Imaging1Obesity, Abdominal1
Journals, researchers & institutions
Top journals
  • Cardiovascular drugs and therapy1
  • Clinical genitourinary cancer1
  • Diabetes1
  • Heart rhythm1
  • Microcirculation (New York, N.Y. : 1994)1
  • Neurology1
Leading researchers
  • Byrne CD2
  • Chipperfield AJ2
  • Clough GF2
  • Gamble J2
  • Krentz AJ2
  • Turzyniecka M2
  • Walter L2
  • Abbara S1
Leading institutions
free-text, unnormalised
  • Brigham and Women's Hospital and Harvard Medical School2
  • Institute of Developmental Sciences1
  • Massachusetts General Hospital and Harvard Medical School1
  • McGuire Veterans Affairs Medical Center1
  • Nemours Children's Clinic1
  • Rambam Medical Center1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Pravastatin

Studied across 3 of the same disease areas as Atorvastatin in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials