Back to discover
Drug

Pravastatin

In clinical development
Emerging researchLate-stage development
Also known as Pravachol, Pravastatin acid, Pravastatina, Pravastatine+2 more

Pravachol, Pravastatin acid, Pravastatina, Pravastatine, Pravastatin Sodium, Pravastatinum.

RxNorm42463ChEMBLCHEMBL1144ATCC10AA03UNIIKXO2KT9N0G
2
Research papers
6
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

TRADstat: Novel Treatment of Radiation Associated Dysphagia With Statins

Clinical trial2026-03-03Results expected Q4 2028 · ClinicalTrials.gov

Statin Intervention for Severe Early-Onset Placental Insufficiency: A Randomized Controlled Trial Assessing Daily Administration as a Treatment Strategy (STATIN-PRE Trial)

Clinical trial2026-02-23Results expected Q4 2027 · ClinicalTrials.gov

Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

Clinical trial2026-02-13Results expected Q2 2029 · ClinicalTrials.gov

Improving Theempowerment in Patients With Severe Breast Fibrosis Radio-induced Treated by Pravastatin : Benefit of e-PROs (Electronic " Patient Reported Outcome ") on Breast-related Quality of Life

Clinical trial2026-01-31Primary completion · ClinicalTrials.gov

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Clinical trial2026-01-26Results expected Q1 2031 · ClinicalTrials.gov

Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease

Clinical trial2025-08-04Completed · ClinicalTrials.gov

Pilot Trial of Pravastatin as a Novel Prophylactic Medicine to Reduce Endothelial Injury in Pediatric Patients With Elevated Body Mass Index

Clinical trial2025-03-05Completed · ClinicalTrials.gov

A Relative Bioavailability Study of 80 mg Pravastatin Sodium Tablets Under Non-Fasting Conditions

Clinical trial2024-08-20Results posted · ClinicalTrials.gov

A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk Women

Clinical trial2024-06-20Terminated · ClinicalTrials.gov

Statin Therapy in Patients With Early Stage ADPKD

Clinical trial2024-03-25Primary completion · ClinicalTrials.gov

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

Research2004-03-08The New England journal of medicine

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.

Research1998-11-01The New England journal of medicine

Evidence confidence

1 claim

How strongly the incorporated evidence supports specific clinical claims about this treatment. A confidence figure is a current summary of evidence strength, not a permanent verdict.

Lowers LDL cholesterol in hyperlipidaemia
52%Moderate confidence
Uncertainty ±21%Evidence coverage: SubstantialUpdated 5 August 2022

High point estimate, but substantial uncertainty remains.

Evidence is mixed — 5 supporting evidence families · contradictory evidence

Confidence has a moderate point estimate but a wide uncertainty band — the evidence base is still thin.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Pravastatin
Aliases & brands
PravacholPravastatin acidPravastatinaPravastatinePravastatin SodiumPravastatinum
RxNorm CUI
42463
ChEMBL ID
CHEMBL1144
ATC codes
C10AA03
UNII
KXO2KT9N0G

Clinical trials

105 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
105
registered trials across all phases
LATEST COMPLETION 2025
6
Active studies
5
Recruiting
52
Late-stage (III+)
78
Completed
21
Discontinued
PHASE DISTRIBUTIONn = 105
Early Phase 11Phase 129Phase 1 / 21Phase 222Phase 317Phase 426Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Statin Therapy in Patients With Early Stage ADPKD

Active, not recruitingPH IVUniversity of Colorado, Denvern=1502025

The Influence of Statins on Glucose Homeostasis and the Biomarkers of Diabetes in Subjects With Impaired Fasting Glucose

Unknown statusPH IVTaipei Veterans General Hospital, Taiwann=1602022

Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease

CompletedPH IVDong-A Universityn=622018

Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes

CompletedPH IVSamsung Medical Centern=442017

Effects of High-dose Statin Treatments on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Drug-eluting Stents Implantation: a Randomized Controlled Study

Unknown statusPH IVKey trialYonsei Universityn=2,0002015

Recent completions

Trials that read out recently, adding to the completed evidence base.

Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease

CompletedPH IIUniversity of Southern Californian=12025

Pilot Trial of Pravastatin as a Novel Prophylactic Medicine to Reduce Endothelial Injury in Pediatric Patients With Elevated Body Mass Index

CompletedPH IChildren's Hospital Medical Center, Cincinnatin=252025

Pravastatin for the Prevention of Preeclampsia in High-Risk Women: A Phase I Pilot Study

CompletedPH IThe University of Texas Medical Branch, Galvestonn=482024

A Phase 1, Single-center, Open-label, Sequential Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants

CompletedPH IBristol-Myers Squibbn=182023

StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis

CompletedPH IINational Institute of Allergy and Infectious Diseases (NIAID)n=162022

Statin Adjunctive Therapy for TB (StAT- TB)

CompletedPH IIJohns Hopkins Universityn=162022

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19982004
Journals, researchers & institutions
Top journals
  • The New England journal of medicine2
Leading researchers
  • Belder R1
  • Braunwald E1
  • Cannon CP1
  • Hill KA1
  • Joyal SV1
  • McCabe CH1
  • Pfeffer MA1
  • Rader DJ1
Leading institutions
free-text, unnormalised
  • Brigham and Women's Hospital and Harvard Medical School1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Atorvastatin

Studied across 3 of the same disease areas as Pravastatin in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials