Back to discover
Drug

Berberine

In clinical development
Emerging researchLate-stage development
RxNorm1437ChEMBLCHEMBL295124UNII0I8Y3P32UF
1
Research papers
6
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Study on the Mechanism s of Berberine Improving Cognitive Impairments in Schizophrenia Based on Gut-brain Axis

Clinical trial2026-04-23Completed · ClinicalTrials.gov

Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms

Clinical trial2026-01-01Primary completion · ClinicalTrials.gov

Assessing the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine Using Randomized, Placebo-controlled, Double-masked Trial

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes: A Pilot Randomized Clinical Study

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: A Randomized Controlled Trial

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.

Clinical trial2025-06-30Completed · ClinicalTrials.gov

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

Clinical trial2025-06-25Completed · ClinicalTrials.gov

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Clinical trial2024-11-01Primary completion · ClinicalTrials.gov

Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial

Clinical trial2023-12-30Primary completion · ClinicalTrials.gov

Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis: a Prospective Cohort Study

Clinical trial2023-10-31Primary completion · ClinicalTrials.gov

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.

Research2021-02-24Signal transduction and targeted therapy

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Berberine
RxNorm CUI
1437
ChEMBL ID
CHEMBL295124
UNII
0I8Y3P32UF

Clinical trials

36 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
36
registered trials across all phases
LATEST COMPLETION 2026
6
Active studies
6
Recruiting
32
Late-stage (III+)
19
Completed
11
Discontinued
PHASE DISTRIBUTIONn = 36
Phase 1 / 22Phase 22Phase 2 / 33Phase 34Phase 416Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy and Safety of Berberine on Primary Prevention of Cardiovascular Diseases and Diabetes in Metabolic Syndrome: a Randomized, Controlled Trial

Not yet recruitingPH IVKey trialTang Yidan=5,2002028

Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: A Randomized Controlled Trial

Not yet recruitingPH IVSecond Xiangya Hospital of Central South Universityn=2402026

A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention

RecruitingPH IVPeking Union Medical College Hospitaln=642026

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=5582025

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Unknown statusPH IVXijing Hospital of Digestive Diseasesn=5482024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Study on the Mechanism s of Berberine Improving Cognitive Impairments in Schizophrenia Based on Gut-brain Axis

CompletedN/ATianjin Anding Hospitaln=1242026

A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.

CompletedN/AYu Chenn=1102025

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=5582025

Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication

CompletedPH IVXijing Hospital of Digestive Diseasesn=3002022

Efficacy and Safety of Berberine Hydrochloride, Amoxicillin and Rabeprazole Triple Therapy in the First Eradication of Helicobacter Pylori

CompletedPH IVXijing Hospital of Digestive Diseasesn=5242021

Multicenter Randomized Controlled Study of Berberine for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Diabetes and Renal Insufficient

CompletedPH IVNanjing First Hospital, Nanjing Medical Universityn=8002021

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.

Signal transduction and targeted therapy · 2021 · 223 cites
Journals, researchers & institutions
Top journals
  • Signal transduction and targeted therapy1
Leading researchers
  • Cao X1
  • Cong L1
  • Fu J1
  • Gao TL1
  • Han P1
  • Jiang JD1
  • Li XY1
  • Lin Y1
Leading institutions
free-text, unnormalised
  • Department of Immunology & Centre for Immunotherapy1
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines1
  • The First Hospital of Jilin University1

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Dihydroberberine

Studied across the same disease area as Berberine in the shared literature.

1 shared disease1 shared paper
Dopamine

Studied across the same disease area as Berberine in the shared literature.

1 shared disease1 shared paper
Levodopa

Studied across the same disease area as Berberine in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials