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Drug

Dopamine

Approved · EMA
Actively researchedLate-stage developmentCooling momentum
Also known as 3-Hydroxytyramine, 4-(2-aminoethyl)catechol, 4-(2-aminoethyl)pyrocatechol, Oxytyramine+7 more

3-Hydroxytyramine, 4-(2-aminoethyl)catechol, 4-(2-aminoethyl)pyrocatechol, Oxytyramine, Dopamina, 2-(3,4-dihydroxyphenyl)ethylamine, 3,4-Dihydroxyphenethylamine, 4-(2-Aminoethyl)benzene-1,2-diol, 4-(2-aminoethyl)-1,2-benzenediol, DOPamine Hydrochloride, Dopaminum.

45
Research papers
4
Active clinical trials
1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Approval: Neoatricon (EMA)

Regulatory2024-05-27EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Dopamine
Aliases & brands
3-Hydroxytyramine4-(2-aminoethyl)catechol4-(2-aminoethyl)pyrocatecholOxytyramineDopamina2-(3,4-dihydroxyphenyl)ethylamine3,4-Dihydroxyphenethylamine4-(2-Aminoethyl)benzene-1,2-diol4-(2-aminoethyl)-1,2-benzenediolDOPamine HydrochlorideDopaminum
RxNorm CUI
3628
ChEMBL ID
CHEMBL59
ATC codes
C01CA04
UNII
VTD58H1Z2X
Regulatory jurisdictions
ema

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2024-05-27
Latest approval
2024-05-27
Authorities
EMA
Total events
1
emaEuropean Medicines Agency· 1 event
2024-05-27Approval
Approval: Neoatricon (EMA)

Indication: Treatment of hypotension in haemodynamically unstable neonates, infants and children < 18 years

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

27 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
27
registered trials across all phases
LATEST COMPLETION 2025
4
Active studies
4
Recruiting
21
Late-stage (III+)
11
Completed
12
Discontinued
PHASE DISTRIBUTIONn = 27
Phase 14Phase 22Phase 2 / 32Phase 33Phase 47Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

45 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19802026
Most influential

The role of oxidative stress in Parkinson's disease.

Journal of Parkinson's disease · 2013 · 1,292 cites

A framework for mesencephalic dopamine systems based on predictive Hebbian learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996 · 1,240 cites

The neuroscience of natural rewards: relevance to addictive drugs.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002 · 902 cites
Recent papers
Major research themes8
Parkinson Disease10Dopamine7Reward6Parkinsonian Disorders3Behavior, Animal2Brain2Deep Brain Stimulation2Memory2
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences5
  • The Journal of neuroscience : the official journal of the Society for Neuroscience5
  • The Journal of clinical investigation3
  • eLife2
  • Journal of Parkinson's disease2
  • Nature communications2
Leading researchers
  • Calabresi P2
  • di Porzio U2
  • Lin Y2
  • Mercuri NB2
  • Neumann WJ2
  • Patriarchi T2
  • Rodríguez-Oroz MC2
  • Shi Z2
Leading institutions
free-text, unnormalised
  • Albert Einstein College of Medicine2
  • Charité - Universitätsmedizin Berlin2
  • Howard Hughes Medical Institute2
  • School of Medicine and Surgery2
  • University of California2
  • University of Toronto2

Related diseases

7 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 4 of the same disease areas as Dopamine in the shared literature.

4 shared diseases3 shared papers

Studied across 3 of the same disease areas as Dopamine in the shared literature.

3 shared diseases1 shared paper

Studied across 3 of the same disease areas as Dopamine in the shared literature.

3 shared diseases1 shared paper

Studied across 2 of the same disease areas as Dopamine in the shared literature.

2 shared diseases1 shared paper

Studied across the same disease area as Dopamine in the shared literature.

1 shared disease1 shared paper

Studied across the same disease area as Dopamine in the shared literature.

1 shared disease1 shared paper

Frequently co-studied with Dopamine in the research literature.

1 shared paper

Frequently co-studied with Dopamine in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.