Drug

beta Carotene

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as B-Caro-T, CAROTENE,BETA, Caroguard, Macuvite with Lutein+8 more

B-Caro-T, CAROTENE,BETA, Caroguard, Macuvite with Lutein, Ocuvite, PreserVision, Provitamin A, Solatene, vitamin A (as beta carotene), .BETA.-CAROTENE, BETA-CAROTENE, Betacarotene.

RxNorm19143 ChEMBLCHEMBL1293 ATCD02BB01 ATCA11CA02UNII01YAE03M7J

Research papers

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots.

Research2023-09-28Nature plants

The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates

Clinical trial2018-12-01Primary completion · ClinicalTrials.gov

The Effect of Zinc, Beta-carotene, and Vitamin D3 Supplementation as Pro-inflammation Mediated Regulator in Preterm Delivery Through Placental Protein Adaptor MyD88 and TRIF, Transcription Factor NFkB, and Pro-inflammatory Cytokine IL-1β

Clinical trial2017-06-01Completed · ClinicalTrials.gov

Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)

Clinical trial2005-07-01Completed · ClinicalTrials.gov

Randomized Trial of Beta-Carotene and Macular Degeneration

Clinical trial2005-06-24Status unknown · ClinicalTrials.gov

Randomized Trials of Vitamin Supplements and Eye Disease

Clinical trial2005-06-24Status unknown · ClinicalTrials.gov

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Research2001-10-01Archives of ophthalmology (Chicago, Ill. : 1960)

Arterial Disease Multifactorial Intervention Trial (ADMIT)

Clinical trial1999-03-01Completed · ClinicalTrials.gov

Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial.

Research1996-11-01Journal of the National Cancer Institute

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

beta Carotene

Aliases & brands

B-Caro-TCAROTENE,BETACaroguardMacuvite with LuteinOcuvitePreserVisionProvitamin ASolatenevitamin A (as beta carotene).BETA.-CAROTENEBETA-CAROTENEBetacarotene

RxNorm CUI

19143

ChEMBL ID

CHEMBL1293

ATC codes

D02BB01A11CA02

UNII

01YAE03M7J

Clinical trials

6 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2017

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 6

Phase 21Phase 33Phase 42

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates

Unknown statusPH IVIndonesia Universityn=1202019

CompletedPH IVIndonesia Universityn=562017

Randomized Trials of Vitamin Supplements and Eye Disease

Unknown statusPH IIINational Eye Institute (NEI)2005

Randomized Trial of Beta-Carotene and Macular Degeneration

Unknown statusPH IIINational Eye Institute (NEI)2005

Arterial Disease Multifactorial Intervention Trial (ADMIT)

CompletedPH IIINational Heart, Lung, and Blood Institute (NHLBI)1999

Recent completions

Trials that read out recently, adding to the completed evidence base.

CompletedPH IVIndonesia Universityn=562017

Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)

CompletedPH IIBrigham and Women's Hospital2005

Arterial Disease Multifactorial Intervention Trial (ADMIT)

CompletedPH IIINational Heart, Lung, and Blood Institute (NHLBI)1999

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19962023

Most influential

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Archives of ophthalmology (Chicago, Ill. : 1960) · 2001 · 1,978 cites

Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial.

Journal of the National Cancer Institute · 1996 · 704 cites

Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots.

Nature plants · 2023 · 35 cites

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Ascorbic Acid

Studied across 2 of the same disease areas as beta Carotene in the shared literature.

2 shared diseases1 shared paper

Retinol palmitate

Studied across the same disease area as beta Carotene in the shared literature.

1 shared disease1 shared paper

Vitamin A

Studied across the same disease area as beta Carotene in the shared literature.

1 shared disease1 shared paper

Carotenoids

Frequently co-studied with beta Carotene in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials