Drug

Vitamin A

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as Aquasol A, Infuvite, Infuvite Pediatric, Lactocal+16 more

Aquasol A, Infuvite, Infuvite Pediatric, Lactocal, Lazer Creme, MVC-Fluoride, Multi-Delyn, Poly-Vi-Sol, Poly-Vi-Sol with Iron, Prenatal Rx 1, RETINOL, Tri-Vi-Sol, Tri-Vi-Sol with Iron, Vitafol-One, Vital E- A + D3, Vital E- Newborn, Vital E- Repro, Vitamin A Alcohol, Viva-Drops, retinol (vit A).

RxNorm11246 ChEMBLCHEMBL986 ATCD10AD02 ATCS01XA02 ATCA11CA01 ATCR01AX02UNIIG2SH0XKK91

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A vitamin A discovery is changing what scientists know about vision

Industry2026-07-09Science Daily

A vitamin A discovery is changing what scientists know about vision

Industry2026-07-09Science Daily

Randomized Study of Vitamin A and D Prophylaxis Before Allogeneic Related and Unrelated Hematopoietic Stem Cell Transplantation

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

Pilot Trial of Supplemental Vitamin A and Nicotinamide and Levels of Blood Vitamin A and Nicotinamide

Clinical trial2026-03-20Results expected Q1 2028 · ClinicalTrials.gov

Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection

Clinical trial2026-03-01Primary completion · ClinicalTrials.gov

A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

Clinical trial2025-08-12Results expected Q3 2027 · ClinicalTrials.gov

A Prospective, Single-arm, Single-center, Phase II Clinical Trial to Evaluate the Efficacy of Quintuple Method for the Treatment of Multiple Refractory Colorectal Liver Metastases

Clinical trial2025-03-15Primary completion · ClinicalTrials.gov

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.

Research2024-01-08Frontiers in immunology

Efficacy and Safety of Vitamin A Treatment for Children With Sepsis: a Randomized Placebo-controlled Clinical Trial

Clinical trial2023-12-31Primary completion · ClinicalTrials.gov

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients.

Research2023-12-12Allergy

The Role of Micronutrients in Neurological Disorders.

Research2023-09-25Nutrients

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations.

Research2023-08-11Molecules (Basel, Switzerland)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Vitamin A

Aliases & brands

Aquasol AInfuviteInfuvite PediatricLactocalLazer CremeMVC-FluorideMulti-DelynPoly-Vi-SolPoly-Vi-Sol with IronPrenatal Rx 1RETINOLTri-Vi-SolTri-Vi-Sol with IronVitafol-OneVital E- A + D3Vital E- NewbornVital E- ReproVitamin A AlcoholViva-Dropsretinol (vit A)

RxNorm CUI

11246

ChEMBL ID

CHEMBL986

ATC codes

D10AD02S01XA02A11CA01R01AX02

UNII

G2SH0XKK91

Clinical trials

41 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2022

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 41

Early Phase 12Phase 12Phase 1 / 22Phase 28Phase 2 / 31Phase 36Phase 412Phase N / A8

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Randomised Trial of Vitamin A Supplementation Given With Routine Childhood Vaccines at National Immunisation Days

Unknown statusPH IVKey trialBandim Health Projectn=6,2002014

The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis

CompletedPH IVTehran University of Medical Sciencesn=362014

Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries? Randomized Prospective Studies in Guinea-Bissau

Unknown statusPH IVKey trialBandim Health Projectn=7,6002013

The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality

CompletedPH IVKey trialBandim Health Projectn=11,0002013

Should Infants Receive High-dose Vitamin A Supplementation With BCG Vaccine at Birth in Developing Countries?

CompletedPH IVKey trialBandim Health Projectn=4,8002013

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effects of Retinoids on CYP2D6 Activity and Variability in Special Populations

CompletedPH IUniversity of Washingtonn=822022

Vitamin A Supplementation of Breast Feeding Mothers and Their Neonates at Delivery: Impact on Mother to Child Transmission of HIV During Lactation, HIV Infection Among Women During the Postpartum Year, and Infant Mortality.

CompletedPH IIJohns Hopkins Bloomberg School of Public Healthn=28,2202020

Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine (SB257049) Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever Vaccines Followed by a Booster of the Malaria Vaccine.

CompletedPH IIIGlaxoSmithKlinen=6992020

This Was a Phase 1/2, Double-blind, Randomized, Placebo-controlled, Dose-escalation Study Conducted at a Single Center for the Healthy Volunteer Cohorts in up to 56 Participants. It Consisted of 1 Single-dose Cohort and 3 Multiple-dose Cohorts (n = 12 Per Cohort, 10 Active:2 Placebo). The Open-label, hATTR Patient Cohort Portion of the Study Was Conducted at Multiple Centers.

CompletedPH I/IIIonis Pharmaceuticals, Inc.n=472020

Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants

CompletedN/AHuiqing Sunn=2622017

The Study of the Effects of Vitamin A Supplementation on Immune System and Th1/Th2 Balance in Patients With Multiple Sclerosis

CompletedPH IVTehran University of Medical Sciencesn=362014

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19962024

Most influential

Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial.

Journal of the National Cancer Institute · 1996 · 704 cites

Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network.

The New England journal of medicine · 1999 · 328 cites

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients.

Allergy · 2024 · 32 cites

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.

Frontiers in immunology · 2023 · 31 cites

The Role of Micronutrients in Neurological Disorders.

Nutrients · 2023 · 16 cites

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations.

Molecules (Basel, Switzerland) · 2023 · 13 cites

Related drugs

5 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Trace Elements

Studied across 2 of the same disease areas as Vitamin A in the shared literature.

2 shared diseases2 shared papers

Amino Acids

Studied across 2 of the same disease areas as Vitamin A in the shared literature.

2 shared diseases1 shared paper

Vitamin K

Studied across the same disease area as Vitamin A in the shared literature.

1 shared disease2 shared papers

beta Carotene

Studied across the same disease area as Vitamin A in the shared literature.

1 shared disease1 shared paper

Retinol palmitate

Studied across the same disease area as Vitamin A in the shared literature.

1 shared disease1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials