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Drug

Vitamin K

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as Vitamin K (Phytonadione), Viactiv Calcium Plus D, Vitamin K and/or vitamin K derivative.

6

Research papers

2

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Vitamin K Reversal of INR for Perioperative Management of Warfarin: : A Pilot Study to Assess Feasibility

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

The risk of refusing a newborn’s vitamin K shot

Industry2026-07-14STAT News

A Phase I, Multicenter, Open-Label, Single-Agent Study to Assess the Pharmacokinetics of Cytochrome P450 Substrates After Treatment With Afimkibart in Participants With Moderately to Severely Active Ulcerative Colitis

Clinical trial2026-06-24Results expected Q3 2027 · ClinicalTrials.gov

A Phase 1, Open-label, Drug-Drug Interaction Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple CYP450 Substrates in Patients With Moderate to Severe Atopic Dermatitis

Clinical trial2025-02-12Completed · ClinicalTrials.gov

Osteocalcin in Bone Metabolism and Aging: Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin, on Glucose and Energy Metabolism and on Muscle Mass and Function

Clinical trial2024-07-04Terminated · ClinicalTrials.gov

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.

Research2024-01-08Frontiers in immunology

Dietary and Non-dietary Components of Vitamin K Metabolism

Clinical trial2023-11-29Results posted · ClinicalTrials.gov

Preventing Cefoperazone/Sulbactam Induced Coagulopathy in Critically Ill Egyptian Patients: Efficacy of Vitamin K Prophylactic Doses

Clinical trial2023-10-05Completed · ClinicalTrials.gov

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations.

Research2023-08-11Molecules (Basel, Switzerland)

Comparison of a Decreasing Dose of Daily Intravenous Vitamin K to a Single Dose Given as Standard of Care to an Historical Cohort in Subjects With Larger Burns

Clinical trial2022-10-01Primary completion · ClinicalTrials.gov

α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.

Research2015-03-04The American journal of clinical nutrition

2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.

Research2014-08-29European heart journal

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Vitamin K

Aliases & brands

Vitamin K (Phytonadione)Viactiv Calcium Plus DVitamin K and/or vitamin K derivative

RxNorm CUI

11258

Clinical trials

20 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

20

registered trials across all phases

LATEST COMPLETION 2025

2

Active studies

2

Recruiting

9

Late-stage (III+)

14

Completed

4

Discontinued

PHASE DISTRIBUTIONn = 20

Early Phase 11Phase 110Phase 32Phase 43Phase N / A4

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Vitamin K Reversal of INR for Perioperative Management of Warfarin: : A Pilot Study to Assess Feasibility

RecruitingPH IVUniversity of Michigann=202026

Preventing Cefoperazone/Sulbactam Induced Coagulopathy in Critically Ill Egyptian Patients: Efficacy of Vitamin K Prophylactic Doses

CompletedPH IVHelwan Universityn=562023

Comparison of a Decreasing Dose of Daily Intravenous Vitamin K to a Single Dose Given as Standard of Care to an Historical Cohort in Subjects With Larger Burns

Unknown statusPH IVJoseph M. Still Research Foundation, Inc.n=502022

A Multicenter, Single-Arm, Open-Label Study to Evaluate the Immunogenicity and Pharmacokinetics of BIIB019, Daclizumab High Yield Process (DAC HYP), Prefilled Syringe Administered by Subcutaneous Injection in Subjects With Relapsing-Remitting Multiple Sclerosis

CompletedPH IIIBiogenn=1332016

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

CompletedPH IIINational Institute on Aging (NIA)n=4522006

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Phase 1, Open-label, Drug-Drug Interaction Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple CYP450 Substrates in Patients With Moderate to Severe Atopic Dermatitis

CompletedPH IAmgenn=212025

Preventing Cefoperazone/Sulbactam Induced Coagulopathy in Critically Ill Egyptian Patients: Efficacy of Vitamin K Prophylactic Doses

CompletedPH IVHelwan Universityn=562023

A Phase 1, Open-label, Multiple-probe Drug-drug Interaction Study to Determine the Effect of Rucaparib on Pharmacokinetics of Caffeine, S-Warfarin, Omeprazole, Midazolam, and Digoxin in Patients With Advanced Solid Tumors

CompletedPH Ipharmaand GmbHn=172019

A Phase 1, Four-part, Fixed-sequence, Open-label Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects

CompletedPH ICelgenen=562018

A Multicenter, Single-Arm, Open-Label Study to Evaluate the Immunogenicity and Pharmacokinetics of BIIB019, Daclizumab High Yield Process (DAC HYP), Prefilled Syringe Administered by Subcutaneous Injection in Subjects With Relapsing-Remitting Multiple Sclerosis

CompletedPH IIIBiogenn=1332016

A Phase I, Open-label, Drug Interaction Study to Evaluate the Effect of a Single-dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Subjects With Rheumatoid Arthritis

CompletedPH IJanssen Research & Development, LLCn=122013

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20072023

Most influential

2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.

European heart journal · 2014 · 1,685 cites

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

European heart journal · 2007 · 1,029 cites

α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.

The American journal of clinical nutrition · 2015 · 32 cites

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.

Frontiers in immunology · 2023 · 31 cites

Age group and sex do not influence responses of vitamin K biomarkers to changes in dietary vitamin K.

The Journal of nutrition · 2012 · 19 cites

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations.

Molecules (Basel, Switzerland) · 2023 · 13 cites

Recent papers

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.

Frontiers in immunology · 2023 · 31 cites

Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations.

Molecules (Basel, Switzerland) · 2023 · 13 cites

α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.

The American journal of clinical nutrition · 2015 · 32 cites

2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.

European heart journal · 2014 · 1,685 cites

Age group and sex do not influence responses of vitamin K biomarkers to changes in dietary vitamin K.

The Journal of nutrition · 2012 · 19 cites

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

European heart journal · 2007 · 1,029 cites

Major research themes5

Antioxidants1Deuterium1Mastitis1Trace Elements1Vitamins1

Journals, researchers & institutions

Top journals

European heart journal2
Frontiers in immunology1
Molecules (Basel, Switzerland)1
The American journal of clinical nutrition1
The Journal of nutrition1

Leading researchers

Booth SL2
Fu X2
Saltzman E2
Agnelli G1
Al Rajabi A1
Ardissino D1
Bassand JP1
Bobe G1

Leading institutions

free-text, unnormalised

ALiCE-Associate Laboratory in Chemical Engineering1
CENCIRA Agrofood Research and Innovation Centre1
Centre for Innovative Process Engineering (CENTIV) GmbH1
College of Life Science1
College of Life Sciences1
From the Linus Pauling Institute1

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 5 of the same disease areas as Vitamin K in the shared literature.

5 shared diseases1 shared paper

Studied across 3 of the same disease areas as Vitamin K in the shared literature.

3 shared diseases1 shared paper

Studied across the same disease area as Vitamin K in the shared literature.

1 shared disease2 shared papers

Studied across the same disease area as Vitamin K in the shared literature.

1 shared disease1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
Europe PMC — research literature
ClinicalTrials.gov — clinical trials