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Drug

Nitrates

In clinical development
Emerging researchLate-stage developmentSteady momentum
RxNorm7439
5
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.

Clinical trial2025-07-01Primary completion · ClinicalTrials.gov

A Randomized Trial of Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension

Clinical trial2023-12-01Withdrawn · ClinicalTrials.gov

Efficient conversion of low-concentration nitrate sources into ammonia on a Ru-dispersed Cu nanowire electrocatalyst.

Research2022-05-02Nature nanotechnology

Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (N-FURIOUS)

Clinical trial2021-12-31Terminated · ClinicalTrials.gov

Fate of nitrogen in agriculture and environment: agronomic, eco-physiological and molecular approaches to improve nitrogen use efficiency.

Research2020-10-16Biological research

Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation

Clinical trial2015-05-08Results posted · ClinicalTrials.gov

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

Research2007-06-14European heart journal

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

Research2004-03-01The Plant journal : for cell and molecular biology

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

Research1997-04-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Nitrates
RxNorm CUI
7439

Clinical trials

4 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
4
registered trials across all phases
LATEST COMPLETION 2014
1
Active studies
2
Late-stage (III+)
1
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 4
Phase 11Phase 21Phase 31Phase 41

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.

Active, not recruitingPH IVFondazione Policlinico Universitario Agostino Gemelli IRCCSn=1202025

Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation

CompletedPH IIIUniversity of Toronton=2652014

Recent completions

Trials that read out recently, adding to the completed evidence base.

Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation

CompletedPH IIIUniversity of Toronton=2652014

Research activity

5 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19972022
Most influential

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

The Plant journal : for cell and molecular biology · 2004 · 2,483 cites

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

European heart journal · 2007 · 1,029 cites

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997 · 853 cites

Efficient conversion of low-concentration nitrate sources into ammonia on a Ru-dispersed Cu nanowire electrocatalyst.

Nature nanotechnology · 2022 · 408 cites

Fate of nitrogen in agriculture and environment: agronomic, eco-physiological and molecular approaches to improve nitrogen use efficiency.

Biological research · 2020 · 186 cites
Recent papers

Efficient conversion of low-concentration nitrate sources into ammonia on a Ru-dispersed Cu nanowire electrocatalyst.

Nature nanotechnology · 2022 · 408 cites

Fate of nitrogen in agriculture and environment: agronomic, eco-physiological and molecular approaches to improve nitrogen use efficiency.

Biological research · 2020 · 186 cites

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.

European heart journal · 2007 · 1,029 cites

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

The Plant journal : for cell and molecular biology · 2004 · 2,483 cites

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997 · 853 cites
Major research themes6
Agriculture1Data Display1Environmental Monitoring1Nanowires1Software1Water Purification1
Journals, researchers & institutions
Top journals
  • Biological research1
  • European heart journal1
  • Nature nanotechnology1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
  • The Plant journal : for cell and molecular biology1
Leading researchers
  • Anas M1
  • Ardissino D1
  • Bassand JP1
  • Beckman JS1
  • Bläsing O1
  • Boersma E1
  • Budaj A1
  • Chen FY1
Leading institutions
free-text, unnormalised
  • Argonne National Laboratory1
  • Center for Nanophase Materials Sciences1
  • College of Agriculture1
  • Crop Sciences Institute1
  • Electron Microscope Center1
  • Environmental Molecular Sciences Laboratory1

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Vitamin K

Studied across 5 of the same disease areas as Nitrates in the shared literature.

5 shared diseases1 shared paper
Ammonia

Frequently co-studied with Nitrates in the research literature.

1 shared paper
Ethylene

Frequently co-studied with Nitrates in the research literature.

1 shared paper
Nitrogen

Frequently co-studied with Nitrates in the research literature.

1 shared paper
Starch

Frequently co-studied with Nitrates in the research literature.

1 shared paper
Sucrose

Frequently co-studied with Nitrates in the research literature.

1 shared paper
Trehalose

Frequently co-studied with Nitrates in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials