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Drug

Trehalose

In clinical development
Emerging researchLate-stage development
RxNorm1311373ChEMBLCHEMBL1236395UNIIB8WCK70T7I
1
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Clinical trial2025-10-30Results expected Q4 2028 · ClinicalTrials.gov

A Prospective Study on the Effect of Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers Between Two Ocular Hygiene Regimen Groups

Clinical trial2024-01-01Primary completion · ClinicalTrials.gov

Trehalose as add-on Therapy in Bipolar Depression

Clinical trial2022-10-01Completed · ClinicalTrials.gov

Efficacy of Oral Administration of Trehalose in Patients With Parkinson Disease in Both Idiopathic and Induced by LRRK2 Mutation

Clinical trial2022-08-31Primary completion · ClinicalTrials.gov

The Use of Intravenous Trehalose to Reduce Vascular Inflammation in Acute Coronary Syndrome

Clinical trial2022-05-20Primary completion · ClinicalTrials.gov

Evaluation of the Therapeutic Effects of Trehalose in Patients With Alzheimer Disease

Clinical trial2022-03-20Primary completion · ClinicalTrials.gov

A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Trial of Trehalose for the Treatment of

Clinical trial2018-08-15Withdrawn · ClinicalTrials.gov

Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults

Clinical trial2015-12-01Completed · ClinicalTrials.gov

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

Research2004-03-01The Plant journal : for cell and molecular biology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Trehalose
RxNorm CUI
1311373
ChEMBL ID
CHEMBL1236395
UNII
B8WCK70T7I

Clinical trials

8 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
8
registered trials across all phases
LATEST COMPLETION 2022
1
Active studies
1
Recruiting
4
Late-stage (III+)
2
Completed
5
Discontinued
PHASE DISTRIBUTIONn = 8
Early Phase 11Phase 11Phase 22Phase 31Phase 42Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Prospective Study on the Effect of Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers Between Two Ocular Hygiene Regimen Groups

Unknown statusPH IVUptown Eye Specialistsn=682024

Efficacy of Oral Administration of Trehalose in Patients With Parkinson Disease in Both Idiopathic and Induced by LRRK2 Mutation

Unknown statusPH IVNeuromed IRCCSn=202023

Trehalose as add-on Therapy in Bipolar Depression

CompletedPH IIIConsorcio Centro de Investigación Biomédica en Red (CIBER)n=602022

Recent completions

Trials that read out recently, adding to the completed evidence base.

Trehalose as add-on Therapy in Bipolar Depression

CompletedPH IIIConsorcio Centro de Investigación Biomédica en Red (CIBER)n=602022

Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults

CompletedN/AUniversity of Colorado, Bouldern=1102015

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

The Plant journal : for cell and molecular biology · 2004 · 2,483 cites
Recent papers

MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes.

The Plant journal : for cell and molecular biology · 2004 · 2,483 cites
Major research themes2
Data Display1Software1
Journals, researchers & institutions
Top journals
  • The Plant journal : for cell and molecular biology1
Leading researchers
  • Bläsing O1
  • Gibon Y1
  • Krüger P1
  • Meyer S1
  • Müller LA1
  • Nagel A1
  • Rhee SY1
  • Selbig J1
Leading institutions
free-text, unnormalised
  • Max Planck Institute for Molecular Plant Physiology1

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Ethylene

Frequently co-studied with Trehalose in the research literature.

1 shared paper
Nitrates

Frequently co-studied with Trehalose in the research literature.

1 shared paper
Starch

Frequently co-studied with Trehalose in the research literature.

1 shared paper
Sucrose

Frequently co-studied with Trehalose in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials