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Drug

Bevacizumab

Withdrawn from market

Previously used for Ovarian Epithelial Carcinoma.

ResearchRetrospective safety research
Also known as Alymsys, Avastin, Avzivi, Jobevne+5 more

Alymsys, Avastin, Avzivi, Jobevne, Mvasi, Vegzelma, Zirabev, rhuMAb VEGF, rhuMAb-VEGF.

RxNorm253337UNII2S9ZZM9Q9V
27
Research papers
3
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Approval: Lytenava (EMA)

Regulatory2024-05-27EMA

Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study.

Research2024-05-01Ahn DH · Clinical cancer research : an official journal of the American Association for Cancer Research

Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study.

Research2024-04-01Lou H · Clinical cancer research : an official journal of the American Association for Cancer Research

Market withdrawal: Lextemy (EMA)

Regulatory2021-06-21EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Bevacizumab
Aliases & brands
AlymsysAvastinAvziviJobevneMvasiVegzelmaZirabevrhuMAb VEGFrhuMAb-VEGF
RxNorm CUI
253337
UNII
2S9ZZM9Q9V
Regulatory jurisdictions
emafda

Regulatory timeline

3 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2024-05-27
Latest approval
2026-07-24
Authorities
FDA · EMA
Total events
3
fdaU.S. Food and Drug Administration· 1 event
2026-07-24Approval
Approval: BEVACIZUMAB-VIKG (BLA761320)
Evidence ↗
emaEuropean Medicines Agency· 2 events
2024-05-27Approval
Approval: Lytenava (EMA)

Indication: Lytenava is indicated in adults for treatment of neovascular (wet) age-related macular degeneration (nAMD).

Evidence ↗
2021-06-21Market withdrawalMarket
Market withdrawal: Lextemy (EMA)
Indication: Treatment of carcinoma of the colon or rectum, breast cancer, non-small cell lung cancer, renal cell cancer, epithelial ovarian, fallopian tube or primary peritoneal cancer, andShow full indication

Treatment of carcinoma of the colon or rectum, breast cancer, non-small cell lung cancer, renal cell cancer, epithelial ovarian, fallopian tube or primary peritoneal cancer, and carcinoma of the cervix.

Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Research activity

27 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20032024
Most influential

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.

The New England journal of medicine · 2020 · 5,580 cites

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.

The New England journal of medicine · 2018 · 2,952 cites

Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer.

The New England journal of medicine · 2007 · 2,187 cites

A phase 3 trial of bevacizumab in ovarian cancer.

The New England journal of medicine · 2011 · 1,607 cites

Comprehensive review of targeted therapy for colorectal cancer.

Signal transduction and targeted therapy · 2020 · 1,162 cites
Recent papers
Major research themes8
Colorectal Neoplasms8Colonic Neoplasms6Rectal Neoplasms6Bevacizumab3Antineoplastic Combined Chemotherapy Protocols2Brain Neoplasms2Circulating Tumor DNA2Glioblastoma2
Journals, researchers & institutions
Top journals
  • The New England journal of medicine9
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology6
  • Clinical cancer research : an official journal of the American Association for Cancer Research2
  • Autophagy1
  • BMC gastroenterology1
  • Cancer immunology, immunotherapy : CII1
Leading researchers
  • Modest DP3
  • Tewari KS3
  • Wang M3
  • Bu X2
  • Coleman RL2
  • Colombo N2
  • Dickler M2
  • Elez E2
Leading institutions
free-text, unnormalised
  • German Cancer Research Center (DKFZ)2
  • Ghent University Hospital2
  • Mayo Clinic2
  • Memorial Sloan Kettering Cancer Center2
  • National Cancer Institute2
  • Sarah Cannon Research Institute2

Related diseases

12 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 9 of the same disease areas as Bevacizumab in the shared literature.

9 shared diseases6 shared papers

Studied across 9 of the same disease areas as Bevacizumab in the shared literature.

9 shared diseases5 shared papers

Studied across 11 of the same disease areas as Bevacizumab in the shared literature.

11 shared diseases4 shared papers

Studied across 8 of the same disease areas as Bevacizumab in the shared literature.

8 shared diseases5 shared papers

Studied across 10 of the same disease areas as Bevacizumab in the shared literature.

10 shared diseases3 shared papers

Studied across 14 of the same disease areas as Bevacizumab in the shared literature.

14 shared diseases1 shared paper

Studied across 8 of the same disease areas as Bevacizumab in the shared literature.

8 shared diseases3 shared papers

Studied across 9 of the same disease areas as Bevacizumab in the shared literature.

9 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature
  • Regulatory event sources are credited in the Regulatory Timeline above.