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Drug

Camptothecin

Research stage
Actively researchedCooling momentum
Also known as (S)-(+)-camptothecin, 20(S)-camptothecine, D-camptothecin, (+)-camptothecin+3 more

(S)-(+)-camptothecin, 20(S)-camptothecine, D-camptothecin, (+)-camptothecin, (+)-camptothecine, Camptothecine, 21,22-Secocamptothecin-21-oic acid lactone.

47
Research papers
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this drug.

Datopotamab Deruxtecan in Advanced or Metastatic Non-Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study.

Research2025-01-06Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Trastuzumab Deruxtecan with Nivolumab in HER2-Expressing Metastatic Breast or Urothelial Cancer: Analysis of the Phase Ib DS8201-A-U105 Study.

Research2024-12-01Clinical cancer research : an official journal of the American Association for Cancer Research

Efficacy and Safety of Sacituzumab Govitecan in Patients With Advanced Solid Tumors (TROPiCS-03): Analysis in Patients With Advanced Endometrial Cancer.

Research2024-07-31Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study.

Research2024-05-31Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study.

Research2024-05-01Clinical cancer research : an official journal of the American Association for Cancer Research

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Camptothecin
Aliases & brands
(S)-(+)-camptothecin20(S)-camptothecineD-camptothecin(+)-camptothecin(+)-camptothecineCamptothecine21,22-Secocamptothecin-21-oic acid lactone
RxNorm CUI
1953
ChEMBL ID
CHEMBL65
UNII
XT3Z54Z28A

Research activity

47 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20002026
Most influential

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.

The New England journal of medicine · 2009 · 2,738 cites

Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer.

The New England journal of medicine · 2022 · 1,982 cites

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.

The New England journal of medicine · 2020 · 1,483 cites

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer.

The New England journal of medicine · 2021 · 1,159 cites

Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009 · 1,150 cites
Recent papers
Major research themes8
Immunoconjugates19Breast Neoplasms15Camptothecin10Antibodies, Monoclonal, Humanized9Erb-b2 Receptor Tyrosine Kinases9Trastuzumab8Carcinoma, Non-Small-Cell Lung6Lung Neoplasms6
Journals, researchers & institutions
Top journals
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology13
  • The New England journal of medicine10
  • Nature medicine5
  • Clinical cancer research : an official journal of the American Association for Cancer Research3
  • ESMO open3
  • Annals of oncology : official journal of the European Society for Medical Oncology2
Leading researchers
  • Iwata H8
  • Im SA7
  • Kim SB7
  • Hurvitz SA6
  • Tsurutani J6
  • Cortés J5
  • Curigliano G5
  • Park YH5
Leading institutions
free-text, unnormalised
  • Aichi Cancer Center Hospital8
  • Dana-Farber Cancer Institute8
  • Asan Medical Center6
  • Memorial Sloan Kettering Cancer Center6
  • National Cancer Center Hospital6
  • National Cancer Center Hospital East6

Related diseases

12 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 15 of the same disease areas as Camptothecin in the shared literature.

25 shared papers15 shared diseases

Studied across 18 of the same disease areas as Camptothecin in the shared literature.

18 shared diseases7 shared papers

Studied across 10 of the same disease areas as Camptothecin in the shared literature.

10 shared papers10 shared diseases

Studied across 14 of the same disease areas as Camptothecin in the shared literature.

14 shared diseases6 shared papers

Studied across 10 of the same disease areas as Camptothecin in the shared literature.

10 shared diseases5 shared papers

Studied across 15 of the same disease areas as Camptothecin in the shared literature.

15 shared diseases2 shared papers

Studied across 15 of the same disease areas as Camptothecin in the shared literature.

15 shared diseases2 shared papers

Studied across 12 of the same disease areas as Camptothecin in the shared literature.

12 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature