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Drug

Ado-trastuzumab emtansine

Established medicine
ResearchOngoing research
Also known as KADCYLA, T-DM1, TDM1, TRASTUZUMAB EMTANSINE+2 more

KADCYLA, T-DM1, TDM1, TRASTUZUMAB EMTANSINE, Trastuzumab-DM1, Trastuzumab-MCC-DM1.

RxNorm1371041UNIISE2KH7T06F
17
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Trastuzumab deruxtecan in previously treated patients with HER2-positive metastatic breast cancer: updated survival results from a phase II trial (DESTINY-Breast01).

Research2023-12-11Saura C · Annals of oncology : official journal of the European Society for Medical Oncology

Anti-HER2 Drugs for the Treatment of Advanced HER2 Positive Breast Cancer.

Research2023-10-25Stanowicka-Grada M · Current treatment options in oncology

Mechanisms of Resistance to Antibody-Drug Conjugates.

Research2023-06-02Khoury R · International journal of molecular sciences

Resistance to antibody-drug conjugates in breast cancer: mechanisms and solutions.

Research2022-11-10Chen YF · Cancer communications (London, England)

Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer.

Research2022-03-01Cortés J · The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ado-trastuzumab emtansine
Aliases & brands
KADCYLAT-DM1TDM1TRASTUZUMAB EMTANSINETrastuzumab-DM1Trastuzumab-MCC-DM1
RxNorm CUI
1371041
UNII
SE2KH7T06F

Research activity

17 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20082024
Most influential
Recent papers
Major research themes8
Breast Neoplasms8Immunoconjugates4Trastuzumab3Ado-Trastuzumab Emtansine2Brain Neoplasms2Erb-b2 Receptor Tyrosine Kinases2Antibodies, Monoclonal1Antineoplastic Agents1
Journals, researchers & institutions
Top journals
  • ESMO open4
  • Annals of oncology : official journal of the European Society for Medical Oncology2
  • International journal of molecular sciences2
  • The New England journal of medicine2
  • British journal of cancer1
  • Cancer communications (London, England)1
Leading researchers
  • Curigliano G5
  • Kim SB5
  • Cortés J4
  • Im SA4
  • Iwata H4
  • Cathcart J3
  • Hamilton E3
  • Hurvitz SA3
Leading institutions
free-text, unnormalised
  • Asan Medical Center4
  • Aichi Cancer Center Hospital3
  • European Institute of Oncology3
  • Seoul National University Hospital3
  • Fred Hutchinson Cancer Center2
  • International Breast Cancer Center (IBCC)2

Related diseases

3 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 11 of the same disease areas as Ado-trastuzumab emtansine in the shared literature.

12 shared papers11 shared diseases

Studied across 11 of the same disease areas as Ado-trastuzumab emtansine in the shared literature.

11 shared diseases5 shared papers

Studied across 6 of the same disease areas as Ado-trastuzumab emtansine in the shared literature.

6 shared diseases6 shared papers

Studied across 7 of the same disease areas as Ado-trastuzumab emtansine in the shared literature.

7 shared diseases5 shared papers

Studied across 4 of the same disease areas as Ado-trastuzumab emtansine in the shared literature.

4 shared diseases1 shared paper

Studied across the same disease area as Ado-trastuzumab emtansine in the shared literature.

1 shared disease1 shared paper

Studied across the same disease area as Ado-trastuzumab emtansine in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • Europe PMC — research literature