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Drug

Carbon Dioxide

In clinical development
Emerging researchEarly-to-mid developmentRising momentum

Also known as CO2 - Carbon dioxide, Carbonic anhydride.

RxNorm2034ChEMBLCHEMBL1231871ATCV03AN02UNII142M471B3J
3
Research papers
4
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The oceans near Australia may be the best places to fertilize for removing carbon dioxide

Industry2026-07-29Phys.org — Earth

Ambient concrete carbonation is a trivial contributor in mitigating carbon dioxide emissions from cement production

Industry2026-07-25Manufacturing · Nature — Environmental Sciences

Ambient concrete carbonation is a trivial contributor in mitigating carbon dioxide emissions from cement production

Industry2026-07-25Manufacturing · Nature — Climate Sciences

Global vessel carbon dioxide emission from navigable rivers

Industry2026-07-23Nature — Environmental Sciences

Global vessel carbon dioxide emission from navigable rivers

Industry2026-07-23Nature — Climate Sciences

The Role of Metabolic and Hemodynamic Reserve in Age-Related Brain Vulnerability in Pediatric Sickle Cell Anemia

Clinical trial2026-03-31Primary completion · ClinicalTrials.gov

Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion

Clinical trial2026-03-02Results expected Q1 2032 · ClinicalTrials.gov

Applied Physiology of Oxygen Toxicity: Mechanisms in Humans

Clinical trial2025-10-23Results expected Q3 2026 · ClinicalTrials.gov

Standard vs. Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery: A Randomized Controlled Trial

Clinical trial2024-05-10Results expected Q2 2027 · ClinicalTrials.gov

Far-red light enrichment affects gene expression and architecture as well as growth and photosynthesis in rice.

Research2024-04-17Plant, cell & environment

Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial.

Research2023-09-15Resuscitation

The underpinnings of the BOLD functional magnetic resonance imaging signal.

Research2003-05-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Carbon Dioxide
Aliases & brands
CO2 - Carbon dioxideCarbonic anhydride
RxNorm CUI
2034
ChEMBL ID
CHEMBL1231871
ATC codes
V03AN02
UNII
142M471B3J

Clinical trials

10 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
10
registered trials across all phases
LATEST COMPLETION 2020
4
Active studies
4
Recruiting
6
Late-stage (III+)
5
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 10
Early Phase 11Phase 11Phase 22Phase N / A6

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Multicenter Randomized Clinical Trial of Carbon Dioxide (CO2) Versus Air Insufflation for the Application of Argon Plasma to Reduce the Gastrojejunal Anastomosis in Individuals With Weight Regain After Bypass Surgery.

CompletedN/AKaiser Clinic and Hospitaln=2002020

Predictors of Opioid-Induced Respiratory Depression (OIRD)

CompletedPH IDuke Universityn=302018

CO2 or Physiological Solution as Distension Medium: Which One is Better in Diagnostic Hysteroscopy?

CompletedN/AKey trialFondazione Policlinico Universitario Agostino Gemelli IRCCSn=2,0002017

A Study to Assess the Market Potential of a Carbon Dioxide Nasal Spray in Congested Subjects

CompletedPH IIGlaxoSmithKlinen=1472014

Clearance Rate of Peritoneal Fluid Assessed by Post-operative Ultrasound Decreases After Full Conditioning Pneumoperitoneum

CompletedN/AUniversity Hospital, Gasthuisbergn=202011

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20032024
Major research themes7
Gene Expression Regulation, Plant1Hypercapnia1Light1Oryza1Out-of-Hospital Cardiac Arrest1Photosynthesis1Plant Shoots1
Journals, researchers & institutions
Top journals
  • Plant, cell & environment1
  • Resuscitation1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers
  • Andersen GØ1
  • Bellomo R1
  • Buti S1
  • de Boer HJ1
  • Eastwood G1
  • Flaa A1
  • Huber M1
  • Kahlon PS1
Leading institutions
free-text, unnormalised
  • Austin Hospital1
  • Copernicus Institute of Sustainable Development1
  • Groningen Institute for Evolutionary Life Sciences1
  • Laboratory of Molecular Biology1
  • Laboratory of Plant Physiology1
  • Max Planck Institute for Biological Cybernetics1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Oxygen

Frequently co-studied with Carbon Dioxide in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials