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Drug

Oxygen

In clinical development
Actively researchedLate-stage developmentSteady momentum
Also known as Chemical oxygen, Elemental oxygen, O2 - oxygen, O>2<+2 more

Chemical oxygen, Elemental oxygen, O2 - oxygen, O>2<, Oxygen USP, Pure oxygen.

RxNorm7806ChEMBLCHEMBL1234886ATCV03AN01UNIIS88TT14065
25
Research papers
15
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Efficacy of Nitric Oxide Administration During Cardiopulmonary Bypass in Neonates at Reducing the Risk of Acute Kidney Injury

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

Cerebral Hemodynamic Effects of Oxygen and Antioxidants

Clinical trial2026-04-30Completed · ClinicalTrials.gov

Endotype DIrected Treatment for OSA in Down Syndrome

Clinical trial2026-04-07Results expected Q1 2030 · ClinicalTrials.gov

Oxygen Therapy as an Acute Treatment for Dystonic and/or Plegic Attacks in Alternating Hemiplegia of Childhood

Clinical trial2026-03-31Completed · ClinicalTrials.gov

Success Rate of Intracervical Balloon Placement With Nitrous Oxide Administration. A Randomized Control Study

Clinical trial2026-03-30Withdrawn · ClinicalTrials.gov

A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters

Clinical trial2026-03-12Results posted · ClinicalTrials.gov

Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer

Clinical trial2026-03-06Completed · ClinicalTrials.gov

Restrictive Versus Liberal Oxygenation Targets in Patients With Acute Heart Failure and Pulmonary Congestion - a Randomized Clinical Pilot-trial

Clinical trial2026-03-03Completed · ClinicalTrials.gov

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration.

Research2024-04-23International journal of molecular sciences

Next-generation probiotics: the upcoming biotherapeutics.

Research2024-04-15Molecular biology reports

Targeting the Warburg Effect in Cancer: Where Do We Stand?

Research2024-03-08International journal of molecular sciences

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.

Research2024-02-16Redox biology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Oxygen
Aliases & brands
Chemical oxygenElemental oxygenO2 - oxygenO>2<Oxygen USPPure oxygen
RxNorm CUI
7806
ChEMBL ID
CHEMBL1234886
ATC codes
V03AN01
UNII
S88TT14065

Clinical trials

120 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
120
registered trials across all phases
LATEST COMPLETION 2026
15
Active studies
12
Recruiting
92
Late-stage (III+)
66
Completed
39
Discontinued
PHASE DISTRIBUTIONn = 120
Early Phase 13Phase 16Phase 1 / 23Phase 216Phase 2 / 38Phase 317Phase 431Phase N / A36

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Endotype DIrected Treatment for OSA in Down Syndrome

RecruitingPH IVUniversity of Arizonan=2002030

Perioperative UtiLisation of SupplEmental Oxygen

Active, not recruitingPH IVUniversity Hospital Southampton NHS Foundation Trustn=282026

Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer

CompletedPH IVChina Medical University, Chinan=652026

Substudy: Oxygen Therapy in COPD Patients - Oxidative Stress and Mortality

TerminatedPH IVMikkel Brabrandn=232024

Impact of Oxygen Therapy on Fatigue in Patients With Hypermobile-type Ehlers-Danlos Syndrome: a Randomised Double-blind Placebo-controlled Study

Unknown statusPH IVHospital St. Joseph, Marseille, Francen=822024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Cerebral Hemodynamic Effects of Oxygen and Antioxidants

CompletedN/AErasme University Hospitaln=132026

Oxygen Therapy as an Acute Treatment for Dystonic and/or Plegic Attacks in Alternating Hemiplegia of Childhood

CompletedPH IIAssistance Publique - Hôpitaux de Parisn=242026

Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer

CompletedPH IVChina Medical University, Chinan=652026

Restrictive Versus Liberal Oxygenation Targets in Patients With Acute Heart Failure and Pulmonary Congestion - a Randomized Clinical Pilot-trial

CompletedPH II/IIICopenhagen University Hospital, Hvidovren=1222026

Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Live at High Altitude (2640 Meters Above Sea Level): Evaluation of a Proposal for Adjusting Criteria

CompletedN/AFundación Neumologica Colombianan=2202025

Real Time Assessment of Pre-oxygenation Utilizing End-tidal Oxygen Measurements Versus Single Breath End-Tidal Oxygen Measurements in Healthy Volunteers

CompletedPH IVEmory Universityn=1052023

Research activity

25 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19982024
Most influential

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

Genes & development · 1998 · 1,888 cites

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

Journal of the National Cancer Institute · 2001 · 1,817 cites

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

Oxidative medicine and cellular longevity · 2016 · 732 cites

The underpinnings of the BOLD functional magnetic resonance imaging signal.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003 · 659 cites

Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation.

The Plant cell · 2020 · 504 cites

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis.

Biomolecules · 2021 · 346 cites
Recent papers

Targeting the Warburg Effect in Cancer: Where Do We Stand?

International journal of molecular sciences · 2024 · 126 cites

Next-generation probiotics: the upcoming biotherapeutics.

Molecular biology reports · 2024 · 92 cites

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.

Redox biology · 2024 · 81 cites

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration.

International journal of molecular sciences · 2024 · 18 cites

Immune consequences of exercise in hypoxia: A narrative review.

Journal of sport and health science · 2024 · 13 cites

The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells.

Pharmacological reports : PR · 2023 · 84 cites
Major research themes8
Neoplasms3Gastrointestinal Microbiome2Oxidative Stress2Parkinson Disease2Adaptive Immunity1Ambulatory Care1Antioxidants1Brain Ischemia1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences2
  • Archives of pediatrics & adolescent medicine1
  • Biomolecules1
  • Cephalalgia : an international journal of headache1
  • European journal of sport science1
  • Frontiers in immunology1
Leading researchers
  • Agani F1
  • Al-Fakhrany OM1
  • Amador-Noguez D1
  • Ayata C1
  • Baldassarre G1
  • Banta AB1
  • Barba I1
  • Bhambi BK1
Leading institutions
free-text, unnormalised
  • Abrazo Arizona Heart Hospital1
  • Academic and Clinical Department of Sleep and Breathing and NIHR Respiratory Biomedical Research Unit1
  • Bakersfield Heart Hospital1
  • Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara1
  • Bangabandhu Sheikh Mujib Medical University (BSMMU)1
  • Baskent University1

Related diseases

5 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Nitric Oxide

Studied across 6 of the same disease areas as Oxygen in the shared literature.

6 shared diseases1 shared paper
Amino Acids

Studied across 5 of the same disease areas as Oxygen in the shared literature.

5 shared diseases1 shared paper
Hydrogen Peroxide

Studied across 3 of the same disease areas as Oxygen in the shared literature.

3 shared diseases1 shared paper
Minerals

Studied across 2 of the same disease areas as Oxygen in the shared literature.

2 shared diseases1 shared paper
Platinum

Studied across 2 of the same disease areas as Oxygen in the shared literature.

2 shared diseases1 shared paper
Amino Acids, Essential

Studied across the same disease area as Oxygen in the shared literature.

1 shared disease1 shared paper
Carbon Dioxide

Frequently co-studied with Oxygen in the research literature.

1 shared paper
Kaempferol

Frequently co-studied with Oxygen in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials