Drug

Cefuroxime

In clinical development

Emerging researchLate-stage development

Also known as Ceftin, Cefuroxime Axetil, Cephuroxime, Zinacef+5 more

Ceftin, Cefuroxime Axetil, Cephuroxime, Zinacef, Cefuroxim, Cefuroxima, Cefuroximo, Cefuroxime Sodium, Cefuroximum.

RxNorm2194 ChEMBLCHEMBL1436 ATCJ01DC02 ATCS01AA27UNIIO1R9FJ93ED

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Comparing Placebo Versus Antibiotics for Acute Uncomplicated Diverticulitis

Clinical trial2026-07-08Results expected Q2 2028 · ClinicalTrials.gov

Intravenous Prophylactic Antibiotics and Antimicrobial-Coated Sutures in Preventing Surgical Site Infection in Open Paediatric Groin Surgeries: A 3-arm Randomized Controlled Trial

Clinical trial2026-02-27Primary completion · ClinicalTrials.gov

Standard Versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes After Whipple's Procedure (SPARROW): a Multicenter, Randomized Controlled Trial

Clinical trial2025-07-01Primary completion · ClinicalTrials.gov

Colo-Pro_2: A Feasibility Randomised Controlled Double Blind Trial to Compare Standard Bolus Dosed Cefuroxime Prophylaxis to Bolus-continuous Infusion Dosed Cefuroxime Prophylaxis for the Prevention of Infections After Colorectal Surgery

Clinical trial2025-05-01Primary completion · ClinicalTrials.gov

REINFORCE - Reducing Infection-related Readmissions Following Cystectomy. a Multicentre Randomised Clinical Trial Testing Superiority of Individualised Targeted Antibiotic Prophylaxis Over Empiric Prophylaxis At Ureteral Stent Removal to Reduce Infection-related Readmissions Following Cystectomy.

Clinical trial2025-01-09Results expected Q1 2027 · ClinicalTrials.gov

Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis

Clinical trial2024-09-19Results expected Q4 2027 · ClinicalTrials.gov

Oral + Parenteral Antibiotic Prophylaxis Before Colonic Surgery With vs Without Mechanical Bowel Preparation: a Prospective, Multicentric, Randomised, Controlled Trial.

Clinical trial2024-06-01Primary completion · ClinicalTrials.gov

A Randomized Controlled Study of Qingfei Granule for the Treatment of the Pediatric Acute Upper Respiratory Tract Infection With Bacterial Infection

Clinical trial2023-12-01Primary completion · ClinicalTrials.gov

24 Versus 48 Hours of First Generation or Second Generation Cephalosporin as Prophylaxis to Reduce Surgical Site Infection in Adult Cardiac Surgery Patients: a Randomized Controlled Trial

Clinical trial2022-05-31Completed · ClinicalTrials.gov

Comparative Efficacy of Intravenous Cefuroxime and Ceftriaxone in Preventing Surgical Site Infection After Neurosurgical Procedures

Clinical trial2022-03-05Completed · ClinicalTrials.gov

Intracameral Levofloxacin (0.5%) Versus Intracameral Cefuroxime (1mg/0.1ml) Effect on Corneal Endothelial Cell Count and Morphology in Uneventful Phacoemulsification

Clinical trial2022-01-01Primary completion · ClinicalTrials.gov

Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors.

Research2007-06-01Journal of cataract and refractive surgery

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Cefuroxime

Aliases & brands

CeftinCefuroxime AxetilCephuroximeZinacefCefuroximCefuroximaCefuroximoCefuroxime SodiumCefuroximum

RxNorm CUI

2194

ChEMBL ID

CHEMBL1436

ATC codes

J01DC02S01AA27

UNII

O1R9FJ93ED

Clinical trials

32 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2022

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 32

Early Phase 12Phase 1 / 21Phase 24Phase 31Phase 416Phase N / A8

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis

RecruitingPH IVHospital de Clinicas de Porto Alegren=1002027

RecruitingPH IVRigshospitalet, Denmarkn=2482027

Standard Versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes After Whipple's Procedure (SPARROW): a Multicenter, Randomized Controlled Trial

RecruitingPH IVLeiden University Medical Centern=3442026

Oral + Parenteral Antibiotic Prophylaxis Before Colonic Surgery With vs Without Mechanical Bowel Preparation: a Prospective, Multicentric, Randomised, Controlled Trial.

Unknown statusPH IVHospital Universitari Vall d'Hebron Research Instituten=9682024

24 Versus 48 Hours of First Generation or Second Generation Cephalosporin as Prophylaxis to Reduce Surgical Site Infection in Adult Cardiac Surgery Patients: a Randomized Controlled Trial

CompletedPH IVSaud Al Babtain Cardiac Centern=5682022

Recent completions

Trials that read out recently, adding to the completed evidence base.

24 Versus 48 Hours of First Generation or Second Generation Cephalosporin as Prophylaxis to Reduce Surgical Site Infection in Adult Cardiac Surgery Patients: a Randomized Controlled Trial

CompletedPH IVSaud Al Babtain Cardiac Centern=5682022

Comparative Efficacy of Intravenous Cefuroxime and Ceftriaxone in Preventing Surgical Site Infection After Neurosurgical Procedures

CompletedPH IIDr. Promise Tamunoipiriala Jajan=962022

Preoperative Oral Antibiotics and Surgical Site Infections in Colon Surgery Without Mechanical Bowel Preparation. A Prospective, Multicentre, Single Blinded, Randomized Trial (ORALEV Study)

CompletedPH IVHospital Universitari Vall d'Hebron Research Instituten=5362018

Perioperative Cefuroxime in Obese Patients: Dosage According to the BMI

CompletedPH IVUniversitätsklinikum Hamburg-Eppendorfn=602017

Evaluation of Directed Antimicrobial Prophylaxis for Transrectal Ultrasound Guided Prostate Biopsy (TRUSP)

CompletedPH IVNorthwestern Universityn=5632016

Antibiotic Prophylaxis for Postpartum Infections Following Caesarean Section

CompletedPH IVOdense University Hospitaln=422014

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors.

Journal of cataract and refractive surgery · 2007 · 548 cites

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Levofloxacin

Studied across 3 of the same disease areas as Cefuroxime in the shared literature.

3 shared diseases1 shared paper

Ofloxacin

Studied across 3 of the same disease areas as Cefuroxime in the shared literature.

3 shared diseases1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials