Back to discover
Drug

Ofloxacin

In clinical development
ClassBacterial DNA gyrase inhibitorEmerging researchLate-stage development
Also known as Floxin, OFLX, Ocuflox, Ofloxacin Ophthalmic+5 more

Floxin, OFLX, Ocuflox, Ofloxacin Ophthalmic, Ofloxacin Otic, Ofloxacine, Ofloxacino, 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, Ofloxacinum.

RxNorm7623ChEMBLCHEMBL4ATCJ01MA01ATCS02AA16ATCS01AE01UNIIA4P49JAZ9H
2
Research papers
3
Active clinical trials
2
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

RANSAC guided modeling and evolutionary optimization of UV/sulfite for ofloxacin removal

Industry2026-07-10Nature — Environmental Sciences

Determination of a Trough Serum Concentration of Ofloxacin Associated to Increase in Side Effects Frequency in Elderly Treated for Bone and Joint Infection

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Kahook Dual Blade Surgery

Clinical trial2025-11-10Results expected Q2 2028 · ClinicalTrials.gov

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study

Clinical trial2024-12-01Primary completion · ClinicalTrials.gov

Does the Use of Topical Otic Drops at the Time of Tympanostomy Tube Placement Improve Outcomes When no Middle Ear Effusion is Present at the Time of Surgery

Clinical trial2024-08-06Terminated · ClinicalTrials.gov

VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia

Clinical trial2024-04-23Results posted · ClinicalTrials.gov

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media

Clinical trial2022-07-15Results posted · ClinicalTrials.gov

A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Trabectome Surgery

Clinical trial2021-01-21Withdrawn · ClinicalTrials.gov

Descemet Endothelial Thickness Comparison Trial

Clinical trial2020-11-25Results posted · ClinicalTrials.gov

Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis.

Clinical trial2020-03-10Completed · ClinicalTrials.gov

Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors.

Research2007-06-01Journal of cataract and refractive surgery

Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials.

Research2002-06-01The Journal of antimicrobial chemotherapy

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Ofloxacin
Aliases & brands
FloxinOFLXOcufloxOfloxacin OphthalmicOfloxacin OticOfloxacineOfloxacino8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidOfloxacinum
RxNorm CUI
7623
ChEMBL ID
CHEMBL4
ATC codes
J01MA01S02AA16S01AE01
UNII
A4P49JAZ9H
Primary mechanism
Bacterial DNA gyrase inhibitor

Pharmacology & targets

2 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

DNA gyrase subunit B
gyrB · P0AES6
INHIBITORBacterial DNA gyrase inhibitor
DNA gyrase subunit A
gyrA · P0AES4
INHIBITORBacterial DNA gyrase inhibitor

Clinical trials

18 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
18
registered trials across all phases
LATEST COMPLETION 2021
3
Active studies
3
Recruiting
17
Late-stage (III+)
11
Completed
4
Discontinued
PHASE DISTRIBUTIONn = 18
Phase 11Phase 38Phase 46Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Does the Use of Topical Otic Drops at the Time of Tympanostomy Tube Placement Improve Outcomes When no Middle Ear Effusion is Present at the Time of Surgery

TerminatedPH IVBoston Children's Hospitaln=92024

Descemet Endothelial Thickness Comparison Trial

Unknown statusPH IVOregon Health and Science Universityn=382023

Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis.

CompletedPH IVIstanbul Medipol University Hospitaln=742020

Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials

CompletedPH IVKey trialIstanbul Bakirkoy Maternity and Children Diseases Hospitaln=1,3032013

Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate

Unknown statusPH IVHaEmek Medical Center, Israeln=1602008

Recent completions

Trials that read out recently, adding to the completed evidence base.

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media

CompletedN/AAlejandro Hobermann=2502021

VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia

CompletedN/ALondon Vision Clinicn=1142020

Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis.

CompletedPH IVIstanbul Medipol University Hospitaln=742020

Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection Due to Fluoroquinolones Susceptible Bacteria: a Multicentre, Non-inferiority, Double Blind, Randomized Placebo-controlled Trial

CompletedPH IIIAssistance Publique - Hôpitaux de Parisn=2742019

Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials

CompletedPH IVKey trialIstanbul Bakirkoy Maternity and Children Diseases Hospitaln=1,3032013

Oral Antibiotic Prophylaxis of Early Infection in Multiple Myeloma

CompletedPH IIIGary Morrown=2122012

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20022007
Major research themes3
Antibiotic Prophylaxis1Levofloxacin1Phacoemulsification1
Journals, researchers & institutions
Top journals
  • Journal of cataract and refractive surgery1
  • The Journal of antimicrobial chemotherapy1
Leading researchers
  • Graffunder EM1
  • Venezia RA1
Leading institutions
free-text, unnormalised
  • Albany Medical Center Hospital1

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Levofloxacin

Studied across 5 of the same disease areas as Ofloxacin in the shared literature.

5 shared diseases2 shared papers
Cefuroxime

Studied across 3 of the same disease areas as Ofloxacin in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials