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Drug

Corticosterone

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as 17-deoxycortisol, Compound B, Kendall's compound B, Reichstein's substance H+1 more

17-deoxycortisol, Compound B, Kendall's compound B, Reichstein's substance H, 11beta,21-Dihydroxy-4-pregnene-3,20-dione.

7
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors.

Research2025-09-09Proceedings of the National Academy of Sciences of the United States of America

Ketamine induced synaptic plasticity operates independently of long-term potentiation.

Research2024-06-19Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Identification of targets of leptin action in rat hypothalamus.

Research1996-09-01The Journal of clinical investigation

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Corticosterone
Aliases & brands
17-deoxycortisolCompound BKendall's compound BReichstein's substance H11beta,21-Dihydroxy-4-pregnene-3,20-dione
RxNorm CUI
2876
ChEMBL ID
CHEMBL110739
UNII
W980KJ009P

Clinical trials

1 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
1
registered trials across all phases
1
Late-stage (III+)
1
Discontinued
PHASE DISTRIBUTIONn = 1
Phase 31

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Research activity

7 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19962025
Most influential

Identification of targets of leptin action in rat hypothalamus.

The Journal of clinical investigation · 1996 · 988 cites

Ketamine induced synaptic plasticity operates independently of long-term potentiation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024 · 10 cites

Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors.

Proceedings of the National Academy of Sciences of the United States of America · 2025 · 7 cites
Recent papers
Major research themes8
Hippocampus3Neuronal Plasticity3Stress, Psychological2Anxiety1Brain1Corticosterone1Depression1Electroacupuncture1
Journals, researchers & institutions
Top journals
  • Cell proliferation1
  • Cells1
  • Nature communications1
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology1
  • Proceedings of the National Academy of Sciences of the United States of America1
  • Science (New York, N.Y.)1
Leading researchers
  • Abdel-Hafiz L1
  • Ali AAH1
  • Anstötz M1
  • Baskin DG1
  • Bossi S1
  • Burn P1
  • Campfield LA1
  • Cardoso C1
Leading institutions
free-text, unnormalised
  • Institut de Biologie de l'Ecole Normale Supérieure1
  • Institut du Fer à Moulin1
  • Institute of Anatomy and Cell Biology1
  • Institute of Anatomy II1
  • Institute of Materiobiology1
  • Institute of Neuroanatomy and Cell Biology1

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 2 of the same disease areas as Corticosterone in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Corticosterone in the shared literature.

2 shared diseases1 shared paper

Studied across the same disease area as Corticosterone in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials