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Drug

Deoxycytidine

In clinical development
Emerging researchEarly-to-mid developmentCooling momentum
Also known as 1-(2-deoxy-.beta.-d-ribofuranosyl)cytosine, 2'-Deoxycytidine, 4-amino-1-(2-deoxy-.beta.-d-erythro-pentofuranosyl)-2(1h)-pyrimidinone, CYTIDINE, 2'-DEOXY-+7 more

1-(2-deoxy-.beta.-d-ribofuranosyl)cytosine, 2'-Deoxycytidine, 4-amino-1-(2-deoxy-.beta.-d-erythro-pentofuranosyl)-2(1h)-pyrimidinone, CYTIDINE, 2'-DEOXY-, DOXECITINE, Deoxyribose cytidine, Kygevvi, MT-1621 COMPONENT 2'-DEOXYCYTIDINE, dC, dCYD, 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2- yl)pyrimidin-2(1H)-one.

17
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Nucleoside Therapy in Patients With Telomere Biology Disorders

Clinical trial2026-03-18Results expected Q2 2028 · ClinicalTrials.gov

Nimotuzumab Plus Gemcitabine for K-Ras Wild-Type Locally Advanced or Metastatic Pancreatic Cancer.

Research2023-08-30Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC.

Research2020-10-01The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Deoxycytidine
Aliases & brands
1-(2-deoxy-.beta.-d-ribofuranosyl)cytosine2'-Deoxycytidine4-amino-1-(2-deoxy-.beta.-d-erythro-pentofuranosyl)-2(1h)-pyrimidinoneCYTIDINE, 2'-DEOXY-DOXECITINEDeoxyribose cytidineKygevviMT-1621 COMPONENT 2'-DEOXYCYTIDINEdCdCYD4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2- yl)pyrimidin-2(1H)-one
RxNorm CUI
2642208
ChEMBL ID
CHEMBL66115
UNII
0W860991D6

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
5
registered trials across all phases
LATEST COMPLETION 2019
1
Active studies
1
Recruiting
3
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 5
Phase 13Phase 1 / 21Phase 21

Research activity

17 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042025
Most influential

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer.

The New England journal of medicine · 2018 · 2,091 cites

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC.

The New England journal of medicine · 2020 · 1,238 cites

Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2004 · 1,188 cites

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.

The New England journal of medicine · 2020 · 1,117 cites

Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.

The New England journal of medicine · 2009 · 938 cites

Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2005 · 892 cites
Recent papers
Major research themes8
Pancreatic Neoplasms4Antineoplastic Combined Chemotherapy Protocols3Gemcitabine2Ascorbic Acid1Breast Neoplasms1Chemoradiotherapy, Adjuvant1Cisplatin1Dose Fractionation, Radiation1
Journals, researchers & institutions
Top journals
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology6
  • The New England journal of medicine4
  • Cancer immunology research2
  • International journal of molecular sciences1
  • Nature communications1
  • Nature medicine1
Leading researchers
  • Bhardwaj N2
  • Giaccone G2
  • Hammel P2
  • Herbst RS2
  • Punt CJ2
  • Rugo HS2
  • Abrams TA1
  • Achkar BE1
Leading institutions
free-text, unnormalised
  • Cancer Center of Sun Yat-sen University2
  • Department of Pathology and Laboratory Medicine2
  • Harbin Medical University Cancer Hospital2
  • National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital2
  • Perlmutter Cancer Center2
  • Seoul National University Hospital2

Related diseases

7 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 16 of the same disease areas as Deoxycytidine in the shared literature.

15 shared papers16 shared diseases

Studied across 14 of the same disease areas as Deoxycytidine in the shared literature.

14 shared diseases4 shared papers

Studied across 9 of the same disease areas as Deoxycytidine in the shared literature.

9 shared diseases5 shared papers

Studied across 9 of the same disease areas as Deoxycytidine in the shared literature.

9 shared diseases4 shared papers

Studied across 7 of the same disease areas as Deoxycytidine in the shared literature.

7 shared diseases3 shared papers

Studied across 8 of the same disease areas as Deoxycytidine in the shared literature.

8 shared diseases2 shared papers

Studied across 7 of the same disease areas as Deoxycytidine in the shared literature.

7 shared diseases2 shared papers

Studied across 7 of the same disease areas as Deoxycytidine in the shared literature.

7 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials