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Drug

Elexacaftor

Research stage
ClassCystic fibrosis transmembrane conductance regulator positive modulatorEmerging research
RxNorm2256951ChEMBLCHEMBL4298128UNIIRRN67GMB0V
1
Research papers
CFTR
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Elexacaftor
RxNorm CUI
2256951
ChEMBL ID
CHEMBL4298128
UNII
RRN67GMB0V
Primary mechanism
Cystic fibrosis transmembrane conductance regulator positive modulator

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Cystic fibrosis transmembrane conductance regulator
CFTR · P13569
POSITIVE MODULATORCystic fibrosis transmembrane conductance regulator positive modulator

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes1
Cystic Fibrosis1
Journals, researchers & institutions
Top journals
  • Respiratory research1
Leading researchers
  • Conrad D1
  • Gil M1
  • Gonzalez CT1
  • Guzior DV1
  • Martin C1
  • McClelland M1
  • Mielke J1
  • Okros M1
Leading institutions
free-text, unnormalised
  • Medical University of Vienna1
  • Michigan State University1
  • University of California San Diego1

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Ivacaftor

Acts on the same molecular target as Elexacaftor, with an overlapping disease area.

Shared target1 shared disease1 shared paper
Tezacaftor

Acts on the same molecular target as Elexacaftor, with an overlapping disease area.

Shared target1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature