Drug

Estrogens, Conjugated (USP)

In clinical development

Emerging researchLate-stage development

Also known as Duavee, PMB, Premarin, Premarin with Methyltestosterone+6 more

Duavee, PMB, Premarin, Premarin with Methyltestosterone, Prempro, Conjugated Estrogens, Conjugated equine estrogens, Conjugated estrogen, ESTROGENS, CONJUGATED, ESTROGENS,CONJUGATED.

RxNorm4099UNIIIU5QR144QX

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation

Clinical trial2026-04-16Results expected Q1 2027 · ClinicalTrials.gov

Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection

Clinical trial2024-03-26Results posted · ClinicalTrials.gov

Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials.

Research2023-08-01Menopause (New York, N.Y.)

Large language models generate functional protein sequences across diverse families.

Research2023-01-26Nature biotechnology

The Estrogen Impact on Overactive Bladder Syndrome: Female Pelvic Floor Microbiomes and Antimicrobial Peptides

Clinical trial2021-04-15Results posted · ClinicalTrials.gov

Resuscitative Endocrinology: (RESCUE - Shock): A Phase II Trial to Evaluate the Effects of Single Dose Intravenous Premarin for Treatment of Patients With Hemorrhagic Shock

Clinical trial2020-03-19Results posted · ClinicalTrials.gov

A Phase II Trial to Evaluate the Effects of A Single Dose of Intravenous Premarin for the Treatment of Severe Traumatic Brain Injury

Clinical trial2019-11-12Results posted · ClinicalTrials.gov

A Randomized Clinical Trial Comparing Vaginal Laser Therapy to Vaginal Estrogen Therapy in Women With Genitourinary Syndrome of Menopause

Clinical trial2019-10-30Results posted · ClinicalTrials.gov

A Combined Treatment Program for the Symptoms of Urinary Urgency and Frequency With Toviaz and Premarin Vaginal Cream

Clinical trial2018-04-01Primary completion · ClinicalTrials.gov

A Parallel-group, Double-blind, Randomized, Placebo-controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Two Doses of GSK232802 Administered Orally as Monotherapy for 12 Weeks in Healthy Postmenopausal Women With Moderate to Extremely Severe Vasomotor Symptoms

Clinical trial2017-10-03Results posted · ClinicalTrials.gov

Patient Adherence to Premarin Versus Vagifem Therapy After Female Pelvic Reconstructive Surgery

Clinical trial2017-07-01Withdrawn · ClinicalTrials.gov

Comparison of Transdermal and Oral Estrogens in Adolescents With Ovarian Failure

Clinical trial2017-01-20Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Estrogens, Conjugated (USP)

Aliases & brands

DuaveePMBPremarinPremarin with MethyltestosteronePremproConjugated EstrogensConjugated equine estrogensConjugated estrogenESTROGENS, CONJUGATEDESTROGENS,CONJUGATED

RxNorm CUI

4099

UNII

IU5QR144QX

Clinical trials

27 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2023

Active studies

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 27

Phase 12Phase 1 / 21Phase 26Phase 2 / 31Phase 37Phase 44Phase N / A6

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Combined Treatment Program for the Symptoms of Urinary Urgency and Frequency With Toviaz and Premarin Vaginal Cream

Unknown statusPH IVThe Cleveland Clinicn=902018

Patient Adherence to Premarin Versus Vagifem Therapy After Female Pelvic Reconstructive Surgery

WithdrawnPH IVUniversity Hospitals Cleveland Medical Center2017

Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients

CompletedPH IVUniversidade Federal do Paranán=692016

Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor

CompletedPH IVUniversity of Texas Southwestern Medical Centern=302013

Estrogen Priming to Increase the Efficacy of Standard Adjuvant Chemotherapy in Operable Breast Cancer.

TerminatedPH IIISudeep Guptan=2732012

Recent completions

Trials that read out recently, adding to the completed evidence base.

Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection

CompletedN/AMayo Clinicn=122023

A Randomized Clinical Trial Comparing Vaginal Laser Therapy to Vaginal Estrogen Therapy in Women With Genitourinary Syndrome of Menopause

CompletedN/AThe Cleveland Clinicn=692018

The Estrogen Impact on Overactive Bladder Syndrome: Female Pelvic Floor Microbiomes and Antimicrobial Peptides

CompletedN/ALoyola Universityn=272017

Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients

CompletedPH IVUniversidade Federal do Paranán=692016

Flow-mediated Evaluation of the Brachial Artery of Climacteric Women Using Estradiol and Placebo. Randomized, Double Blinded, Placebo Controlled Study.

CompletedN/AFederal University of Minas Geraisn=602014

Comparison of Transdermal and Oral Estrogens in Adolescents With Ovarian Failure

CompletedN/AStanford Universityn=202013

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Large language models generate functional protein sequences across diverse families.

Nature biotechnology · 2023 · 747 cites

Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials.

Menopause (New York, N.Y.) · 2023 · 4 cites

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Estrogens

Frequently co-studied with Estrogens, Conjugated (USP) in the research literature.

1 shared paper

Medroxyprogesterone Acetate

Frequently co-studied with Estrogens, Conjugated (USP) in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
Europe PMC — research literature
ClinicalTrials.gov — clinical trials