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Drug

Guanine

Research stage
Emerging research
2
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

First-line crizotinib versus chemotherapy in ALK-positive lung cancer.

Research2014-12-01The New England journal of medicine

Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy.

Research2004-05-01Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Guanine
RxNorm CUI
1372539
ChEMBL ID
CHEMBL219568
UNII
5Z93L87A1R

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042014
Most influential

First-line crizotinib versus chemotherapy in ALK-positive lung cancer.

The New England journal of medicine · 2014 · 2,470 cites

Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2004 · 1,749 cites
Recent papers

First-line crizotinib versus chemotherapy in ALK-positive lung cancer.

The New England journal of medicine · 2014 · 2,470 cites

Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2004 · 1,749 cites
Journals, researchers & institutions
Top journals
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology1
  • The New England journal of medicine1
Leading researchers
  • Blackhall F1
  • Bunn PA Jr1
  • Cappuzzo F1
  • De Marinis F1
  • Desch C1
  • Einhorn L1
  • Felip E1
  • Fossella FV1
Leading institutions
free-text, unnormalised
  • From Peter MacCallum Cancer Centre1
  • Indiana University1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

5 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 4 of the same disease areas as Guanine in the shared literature.

4 shared diseases2 shared papers

Studied across 4 of the same disease areas as Guanine in the shared literature.

4 shared diseases1 shared paper

Studied across 4 of the same disease areas as Guanine in the shared literature.

4 shared diseases1 shared paper

Studied across 4 of the same disease areas as Guanine in the shared literature.

4 shared diseases1 shared paper

Studied across 3 of the same disease areas as Guanine in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature