Research2024-03-01Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer.

Research2023-10-31International journal of molecular sciences

A review of current advancements for wound healing: Biomaterial applications and medical devices.

Research2022-05-17Journal of biomedical materials research. Part B, Applied biomaterials

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation.

Research2021-10-15Biomolecules

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Hyaluronic Acid

Aliases & brands

AmviscHealonHyaluronanHymovisOrthovischyaluronic acid, hydrolyzed

RxNorm CUI

5463

ChEMBL ID

CHEMBL5314376

ATC codes

S01KA51

UNII

S270N0TRQY

Clinical trials

142 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

142

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

101

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 142

Early Phase 15Phase 16Phase 1 / 216Phase 214Phase 2 / 36Phase 318Phase 432Phase N / A45

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Intratympanic Injection of Dexamethasone With Hyaluronic Acid in Treatment of Sudden Sensorineural Hearing Loss

Not yet recruitingPH IVAssiut Universityn=702028

Efficacy of Hyaluronic Acid as Intraoperative Adjuvant in External Dacryocystorhinostomy Compared to Mitomycin-C: A Randomized Controlled Trial

Not yet recruitingPH IVAll India Institute of Medical Sciences, Bhubaneswarn=362027

Comparison of the Efficacy of Combined Hyaluronic Acid and Triamcinolone Acetonide Injection and Hyaluronic Acid Alone Injection in Patients With Subdeltoid Bursitis

Not yet recruitingPH IVShin Kong Wu Ho-Su Memorial Hospitaln=602026

Effects of Hyaluronic Acid and Corticosteroid in Post Extraction Wound Healing of Diabetic Patients

CompletedPH IVRimsha Rasheedn=1282024

Arthroscope-Guided Intra-Articular Injection of Chitosan-Hyaluronate Gel Mixture Versus Hyaluronic Acid in the Treatment of TMJ Internal Derangement: A Randomized Controlled Clinical Trial

Unknown statusPH IVAin Shams Universityn=202024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Clinical Outcomes of Ultrasound-Guided Intra-Articular Hyaluronic Acid Injection Combined With Rehabilitation in Adhesive Capsulitis: A Randomized Controlled Trial

CompletedN/ATri-Service General Hospital (TSGH)n=602026

Comparison of Injectable Platelet-rich Fibrin, Titanium Platelet-rich Fibrin, and 0.8% Hyaluronic Acid Applications in Wound Healing After Gingivectomy and Gingivoplasty Operations: Randomized Controlled Clinical Study.

CompletedN/ASaglik Bilimleri Universitesin=602025

Post-thyroid Surgery Adhesion Prevention Using Oxidized Regenerated Cellulose and Hyaluronic Acid: Prospective, Single-blinded, Randomized Study

CompletedPH INational Taiwan University Hospitaln=452025

Clinical Efficacy and Patient Experience of Adjunctive Hyaluronic Acid-based Gel Application With Coronally Advanced Flap in Type 1 Gingival Recession: A Randomized Controlled Clinical Trial

CompletedPH I/IIOrdu Universityn=202025

Comparative Evaluation Of Hyaluronic Acid, Injectable Platelet-Rich Fibrin, And Dextrose Prolotherapy As Adjuncts To Temporomandibular Joint Arthrocentesis In Patients With Temporomandibular Joint Disorders

CompletedN/AOndokuz Mayıs Universityn=362025

Efficacy of Human UC-MSC-derived Exosomes and BM-MSC-derived Exosomes in Atrophic Acne Scar Treated With Ablative Fractional CO2 Laser: a Split-face Randomized Controlled Prospective Study

CompletedN/ANgô Anh Tuấnn=222025

Research activity

9 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20172024

Most influential

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020 · 373 cites

Hyaluronic Acid: Redefining Its Role.

Cells · 2020 · 315 cites

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation.

Biomolecules · 2021 · 293 cites

Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis

The American journal of sports medicine · 2017 · 261 cites

A review of current advancements for wound healing: Biomaterial applications and medical devices.

Journal of biomedical materials research. Part B, Applied biomaterials · 2022 · 134 cites

Skin boosters: Definitions and varied classifications.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024 · 43 cites

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Neoplasms2

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Paclitaxel

Studied across 6 of the same disease areas as Hyaluronic Acid in the shared literature.

6 shared diseases1 shared paper

Deoxycytidine

Studied across 5 of the same disease areas as Hyaluronic Acid in the shared literature.

5 shared diseases1 shared paper

Gemcitabine

Studied across 5 of the same disease areas as Hyaluronic Acid in the shared literature.

5 shared diseases1 shared paper

Chitosan

Studied across the same disease area as Hyaluronic Acid in the shared literature.

1 shared disease1 shared paper

Silver

Studied across the same disease area as Hyaluronic Acid in the shared literature.

1 shared disease1 shared paper

Polyethylene Glycols

Frequently co-studied with Hyaluronic Acid in the research literature.

1 shared paper

Polyvinyl Alcohol

Frequently co-studied with Hyaluronic Acid in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials