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Drug

Leucine

In clinical development
Emerging researchLate-stage development
Also known as (2S)-2-Amino-4-methylpentanoic acid, (2S)-alpha-2-Amino-4-methylvaleric acid, (2S)-alpha-Leucine, (S)-(+)-Leucine+45 more

(2S)-2-Amino-4-methylpentanoic acid, (2S)-alpha-2-Amino-4-methylvaleric acid, (2S)-alpha-Leucine, (S)-(+)-Leucine, (S)-Leucine, 2-Amino-4-methylvaleric acid, Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free, Aminosyn-HBC 7 %, Sulfite-Free, Aminosyn-PF 10 %, Sulfite-Free, Aminosyn-PF 7%, Branchamin, Clinisol 15, Freamine III 10, Hepatamine 8, Hepatasol, L, L-Leucin, L-Leucine, L-Leuzin, Leu, Nephramine, Plenamine, PremaSol, ProSol, ProcalAmine 3, Travasol 10, Travasol 10%, Trophamine, Trophamine 10 %, Trophamine 6 %, Clinimix 4.25/10, Clinimix 4.25/25, Clinimix 4.25/5, Clinimix 5/15, Clinimix 5/20, Clinimix 5/25, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25.

RxNorm6308ChEMBLCHEMBL291962UNIIGMW67QNF9C
2
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Comparative Study Between Different Additives to Lidocaine 2٪ for Peribulbar Block in Vitreoretinal Surgery (Prospective Comparative Randomized Controlled Trial

Clinical trial2026-06-15Primary completion · ClinicalTrials.gov

Leucine as a Probe of Kynurenine-Induced Glutamate and Neural Circuit Dysfunction in Midlife Depression

Clinical trial2025-04-24Results expected Q2 2028 · ClinicalTrials.gov

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway.

Research2024-03-05eLife

A Pilot Study to Examine Changes in Resistance Training Adaptations After Leucine and Dileucine Ingestion

Clinical trial2023-06-29Completed · ClinicalTrials.gov

The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using Bone Marrow Failure as a Model: a Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia

Clinical trial2022-12-02Results posted · ClinicalTrials.gov

The Efficacy and Safety of 5% Lidocaine Patch for Postoperative Pain in Unilateral Inguinal Herniorrhaphy

Clinical trial2022-11-30Completed · ClinicalTrials.gov

A Pilot Double-Blind Randomized Placebo-Controlled Crossover Study to Investigate Rapid Antidepressant Effects of Leucine

Clinical trial2021-10-04Terminated · ClinicalTrials.gov

An Experimental Treatment Approach for Inflammation-Induced Depression

Clinical trial2021-07-31Terminated · ClinicalTrials.gov

The Effect of Lidocaine to Prevent the Development of Chronic Post-Surgical Pain

Clinical trial2019-11-27Results posted · ClinicalTrials.gov

Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial

Clinical trial2018-08-01Primary completion · ClinicalTrials.gov

Collaborative Research Group for Necrotizing Enterocolitis

Clinical trial2018-04-04Results posted · ClinicalTrials.gov

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes.

Research2005-10-07Nucleic acids research

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Leucine
Aliases & brands
(2S)-2-Amino-4-methylpentanoic acid(2S)-alpha-2-Amino-4-methylvaleric acid(2S)-alpha-Leucine(S)-(+)-Leucine(S)-Leucine2-Amino-4-methylvaleric acidAminosyn 10%, Sulfite-FreeAminosyn 3.5 % M, Sulfite FreeAminosyn 8.5 % with Electrolytes, Sulfite-FreeAminosyn 8.5%, Sulfite-FreeAminosyn II 10 %Aminosyn II 15%Aminosyn II 8.5 % with Electrolytes, Sulfite-FreeAminosyn II 8.5 %, Sulfite-FreeAminosyn-HBC 7 %, Sulfite-FreeAminosyn-PF 10 %, Sulfite-FreeAminosyn-PF 7%BranchaminClinisol 15Freamine III 10Hepatamine 8HepatasolLL-LeucinL-LeucineL-LeuzinLeuNephraminePlenaminePremaSolProSolProcalAmine 3Travasol 10Travasol 10%TrophamineTrophamine 10 %Trophamine 6 %Clinimix 4.25/10Clinimix 4.25/25Clinimix 4.25/5Clinimix 5/15Clinimix 5/20Clinimix 5/25Clinimix E 2.75/5Clinimix E 4.25/10Clinimix E 4.25/5Clinimix E 5/15Clinimix E 5/20Clinimix E 5/25
RxNorm CUI
6308
ChEMBL ID
CHEMBL291962
UNII
GMW67QNF9C

Clinical trials

16 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
16
registered trials across all phases
LATEST COMPLETION 2023
2
Active studies
2
Recruiting
11
Late-stage (III+)
7
Completed
7
Discontinued
PHASE DISTRIBUTIONn = 16
Early Phase 11Phase 1 / 21Phase 23Phase 42Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Efficacy and Safety of 5% Lidocaine Patch for Postoperative Pain in Unilateral Inguinal Herniorrhaphy

CompletedPH IVBON WOOK KOOn=322022

Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial

Unknown statusPH IVAbdelwahed, Mai Mahmoud Mohamed, M.D.n=1302018

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Pilot Study to Examine Changes in Resistance Training Adaptations After Leucine and Dileucine Ingestion

CompletedN/ALindenwood Universityn=342023

The Efficacy and Safety of 5% Lidocaine Patch for Postoperative Pain in Unilateral Inguinal Herniorrhaphy

CompletedPH IVBON WOOK KOOn=322022

The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using Bone Marrow Failure as a Model: a Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia

CompletedPH I/IINorthwell Healthn=552020

The Effect of Nandrolone Decanoate Injection and Leucine Supplementation on Muscle Loss

CompletedN/AMaastricht University Medical Centern=302017

The Effect of Lidocaine to Prevent the Development of Chronic Post-Surgical Pain

CompletedN/ANorthwestern Universityn=1482015

The Effect of Obesity-induced Cytokine Elevation on the Molecular Regulation of Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle

CompletedN/AUniversity of Nottinghamn=262012

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20052024
Major research themes5
Cytokine Release Syndrome1Genome, Archaeal1Genome, Bacterial1Interleukin-41Software1
Journals, researchers & institutions
Top journals
  • eLife1
  • Nucleic acids research1
Leading researchers
  • Begley T1
  • Butler RM1
  • Chen D1
  • Choudhuri JV1
  • Chuang HY1
  • Cohoon M1
  • de Crécy-Lagard V1
  • Diaz N1
Leading institutions
free-text, unnormalised
  • Key Laboratory of Animal Disease Resistance Nutrition of China Ministry of Education1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Coenzyme A

Frequently co-studied with Leucine in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials