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Drug

Mannose

In clinical development
Emerging researchLate-stage development

Also known as D-mannose, DEMANNOSE, MANNOSE, D-.

RxNorm6633ChEMBLCHEMBL1232295UNIIPHA4727WTP
1
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Prospective, Single-Center, Open-Label Study of the Effect of Oral D-mannose Tablets on the Pharmacokinetics of Dabigatran Etexilate in Healthy Adults

Clinical trial2024-11-30Primary completion · ClinicalTrials.gov

The Efficacy and Effect of Methenamine Hippurate in a Non-antibiotic, Multimodal Approach to UTI Prevention

Clinical trial2022-02-11Withdrawn · ClinicalTrials.gov

Preventing Recurrent Urinary Tract Infections With α-D-mannose: a Prospective, Randomized, Double-blinded Placebo-controlled Trial

Clinical trial2020-05-31Terminated · ClinicalTrials.gov

Randomized, Controlled Trial to Determine the Efficacy of Nutraceutical vs Control as Non-antibiotic Prophylaxis for Recurrent Urinary Tract Infection in Postmenopausal Women Using Vaginal Estrogen Therapy

Clinical trial2020-04-25Terminated · ClinicalTrials.gov

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.

Research2019-09-06Cell research

Project 1A) To Determine Whether the Transplacental Gradients for 6 Polyols and Mannose Are Altered in IUGR Pregnancies Compared to Normal Pregnancies. Project 1B) To Determine the Relative Contributions of Transplacental Transport vs. Production by the Conceptus of Both Myoinositol (Major Polyol) and Mannose in IUGR and Normal Pregnancies Using Stable Isotopic Methodology.

Clinical trial2016-12-01Terminated · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Mannose
Aliases & brands
D-mannoseDEMANNOSEMANNOSE, D-
RxNorm CUI
6633
ChEMBL ID
CHEMBL1232295
UNII
PHA4727WTP

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
5
registered trials across all phases
5
Late-stage (III+)
5
Discontinued
PHASE DISTRIBUTIONn = 5
Phase 2 / 31Phase 42Phase N / A2

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Journals, researchers & institutions
Top journals
  • Cell research1
Leading researchers
  • Chang S1
  • Chu X1
  • Ding J1
  • Du C1
  • Feng T1
  • Ge C1
  • Geng M1
  • Gong Y1
Leading institutions
free-text, unnormalised
  • Institutional Technology Service Center1
  • Shanghai Mental Health Center1
  • State Key Laboratory of Drug Research1

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Amino Acids

Studied across 3 of the same disease areas as Mannose in the shared literature.

3 shared diseases1 shared paper
Isoleucine

Studied across 3 of the same disease areas as Mannose in the shared literature.

3 shared diseases1 shared paper
Oligosaccharides

Studied across 3 of the same disease areas as Mannose in the shared literature.

3 shared diseases1 shared paper
Phenylalanine

Studied across 3 of the same disease areas as Mannose in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials