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Drug

Phenylalanine

In clinical development
Emerging researchLate-stage development
Also known as (S)-2-Amino-3-phenylpropionic acid, (S)-alpha-Amino-beta-phenylpropionic acid, 3-phenyl-L-alanine, Aminosyn 10%, Sulfite-Free+43 more

(S)-2-Amino-3-phenylpropionic acid, (S)-alpha-Amino-beta-phenylpropionic acid, 3-phenyl-L-alanine, Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free, Aminosyn-HBC 7 %, Sulfite-Free, Aminosyn-PF 10 %, Sulfite-Free, Aminosyn-PF 7%, Clinisol 15, F, Fenilalanina, Freamine III 10, Hepatamine 8, Hepatasol, L-Phenylalanine, Nephramine, Phe, Plenamine, PremaSol, ProSol, ProcalAmine 3, Travasol 10, Travasol 10%, Trophamine, Trophamine 10 %, Trophamine 6 %, beta-Phenyl-L-alanine, PHE (phenylalanine), Clinimix 4.25/10, Clinimix 4.25/25, Clinimix 4.25/5, Clinimix 5/15, Clinimix 5/20, Clinimix 5/25, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25, Phenylalaninum.

RxNorm8156ChEMBLCHEMBL301523UNII47E5O17Y3R
2
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Study of The Analgesic Profile of Two Adjuvants Added to Low Dose Hyperbaric Bupivacaine Versus One Adjuvant in Patients Undergoing Anal Surgery Using Spinal Anesthesia ( Saddle Block ): A Randomized Prospective Study

Clinical trial2026-02-01Primary completion · ClinicalTrials.gov

Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need.

Research2023-11-03American journal of human genetics

Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients With Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy: A Randamized Controlled Trial

Clinical trial2023-05-15Completed · ClinicalTrials.gov

A Bioequivalence Study of HR20031 Tablet in Healthy Subjects

Clinical trial2023-04-04Completed · ClinicalTrials.gov

PICO: Phenylalanine and Its Impact on Cognition - Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients With Phenylketonuria

Clinical trial2022-06-17Completed · ClinicalTrials.gov

An Open-label, Randomized, Parallel Group, Four/Five Period, Eight Treatment Cross-over, Single Oral Dose Study to Assess the Relative Bioavailability of Different Formulations of AZD9977 and Dapagliflozin and Influence of Food in Selected Formulations in Healthy Volunteers

Clinical trial2021-09-03Completed · ClinicalTrials.gov

A 2-Part, Phase I, Single-Dose, 3-Period Crossover Relative Bioavailability Study of a Pediatric TRIUMEQ Dispersible Tablet and Pediatric Dolutegravir and Lamivudine (DTG/3TC) Fixed Dose Combination Dispersible Tablet Formulations as Compared With Adult Tablets in Healthy Volunteers

Clinical trial2019-12-09Results posted · ClinicalTrials.gov

A Clinical Pharmacology Study to Evaluate the CHF 6532 Linearity After Single Oral Administrations of Four Doses of a Tablet Formulation Followed by an Evaluation of the Pharmacokinetic at Steady State Following the Repeated Open Label b.i.d. Administration at One Dose

Clinical trial2019-11-22Completed · ClinicalTrials.gov

A PHASE 1, OPEN LABEL, CROSSOVER STUDY TO EVALUATE PALATABILITY AND RELATIVE BIOAVAILABILITY OF TWO PEDIATRIC MICROSPHERE FORMULATIONS OF CRIZOTINIB IN HEALTHY PARTICIPANTS

Clinical trial2019-10-17Completed · ClinicalTrials.gov

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.

Research2019-09-06Cell research

Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics Following Different Dosing Regimens of MK-8266 or Placebo in Subjects With Hypertension

Clinical trial2019-02-28Results posted · ClinicalTrials.gov

Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial

Clinical trial2018-08-01Primary completion · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Phenylalanine
Aliases & brands
(S)-2-Amino-3-phenylpropionic acid(S)-alpha-Amino-beta-phenylpropionic acid3-phenyl-L-alanineAminosyn 10%, Sulfite-FreeAminosyn 3.5 % M, Sulfite FreeAminosyn 8.5 % with Electrolytes, Sulfite-FreeAminosyn 8.5%, Sulfite-FreeAminosyn II 10 %Aminosyn II 15%Aminosyn II 8.5 % with Electrolytes, Sulfite-FreeAminosyn II 8.5 %, Sulfite-FreeAminosyn-HBC 7 %, Sulfite-FreeAminosyn-PF 10 %, Sulfite-FreeAminosyn-PF 7%Clinisol 15FFenilalaninaFreamine III 10Hepatamine 8HepatasolL-PhenylalanineNephraminePhePlenaminePremaSolProSolProcalAmine 3Travasol 10Travasol 10%TrophamineTrophamine 10 %Trophamine 6 %beta-Phenyl-L-alaninePHE (phenylalanine)Clinimix 4.25/10Clinimix 4.25/25Clinimix 4.25/5Clinimix 5/15Clinimix 5/20Clinimix 5/25Clinimix E 2.75/5Clinimix E 4.25/10Clinimix E 4.25/5Clinimix E 5/15Clinimix E 5/20Clinimix E 5/25Phenylalaninum
RxNorm CUI
8156
ChEMBL ID
CHEMBL301523
UNII
47E5O17Y3R

Clinical trials

16 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
16
registered trials across all phases
LATEST COMPLETION 2023
1
Active studies
1
Recruiting
5
Late-stage (III+)
14
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 16
Phase 111Phase 42Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

PICO: Phenylalanine and Its Impact on Cognition - Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients With Phenylketonuria

CompletedPH IVInsel Gruppe AG, University Hospital Bernn=902022

Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial

Unknown statusPH IVAbdelwahed, Mai Mahmoud Mohamed, M.D.n=1302018

Recent completions

Trials that read out recently, adding to the completed evidence base.

Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients With Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy: A Randamized Controlled Trial

CompletedN/AHelwan Universityn=642023

A Bioequivalence Study of HR20031 Tablet in Healthy Subjects

CompletedPH IShandong Suncadia Medicine Co., Ltd.n=962023

PICO: Phenylalanine and Its Impact on Cognition - Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients With Phenylketonuria

CompletedPH IVInsel Gruppe AG, University Hospital Bernn=902022

An Open-label, Randomized, Parallel Group, Four/Five Period, Eight Treatment Cross-over, Single Oral Dose Study to Assess the Relative Bioavailability of Different Formulations of AZD9977 and Dapagliflozin and Influence of Food in Selected Formulations in Healthy Volunteers

CompletedPH IAstraZenecan=202021

A Clinical Pharmacology Study to Evaluate the CHF 6532 Linearity After Single Oral Administrations of Four Doses of a Tablet Formulation Followed by an Evaluation of the Pharmacokinetic at Steady State Following the Repeated Open Label b.i.d. Administration at One Dose

CompletedPH IChiesi Farmaceutici S.p.A.n=302019

A PHASE 1, OPEN LABEL, CROSSOVER STUDY TO EVALUATE PALATABILITY AND RELATIVE BIOAVAILABILITY OF TWO PEDIATRIC MICROSPHERE FORMULATIONS OF CRIZOTINIB IN HEALTHY PARTICIPANTS

CompletedPH IPfizern=252019

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20192023
Major research themes2
Phenylalanine Hydroxylase1Phenylketonurias1
Journals, researchers & institutions
Top journals
  • American journal of human genetics1
  • Cell research1
Leading researchers
  • Wang X2
  • Ahrens-Nicklas RC1
  • Brooks DL1
  • Chang S1
  • Chu X1
  • Ding J1
  • Du C1
  • Feng T1
Leading institutions
free-text, unnormalised
  • Cardiovascular Institute1
  • Institutional Technology Service Center1
  • Perelman School of Medicine at the University of Pennsylvania1
  • Shanghai Mental Health Center1
  • State Key Laboratory of Drug Research1

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas
Disease Models, Animal2

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Amino Acids

Studied across 3 of the same disease areas as Phenylalanine in the shared literature.

3 shared diseases1 shared paper
Isoleucine

Studied across 3 of the same disease areas as Phenylalanine in the shared literature.

3 shared diseases1 shared paper
Mannose

Studied across 3 of the same disease areas as Phenylalanine in the shared literature.

3 shared diseases1 shared paper
Oligosaccharides

Studied across 3 of the same disease areas as Phenylalanine in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials