Drug

Nimodipine

In clinical development

ClassMineralocorticoid receptor antagonistEmerging researchLate-stage development

Also known as Nimotop, Nymalize, Nimodipino, Nimodipinum+2 more

Nimotop, Nymalize, Nimodipino, Nimodipinum, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate.

RxNorm7426 ChEMBLCHEMBL1428 ATCC08CA06UNII57WA9QZ5WH

Research papers

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Randomized Controlled Study on the Effects of Nimodipine on Alcohol Drinking Among Adults Who Are Heavy Alcohol Drinkers

Clinical trial2026-07-02Results expected Q2 2032 · ClinicalTrials.gov

A Causal Role for Voltage-gated Cav1.2 Calcium Channels in Mediating 5G FR1 Effects on Sleep-associated Brain Health in Humans

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Perioperative Nimodipine for Intra- and Postoperative Pain Management and Reduction of Anesthetic Requirements in Patients Undergoing Open Colectomy: a Prospective, Double-blind, Randomized Controlled Trial

Clinical trial2026-05-19Primary completion · ClinicalTrials.gov

A Pilot Study on the Effects of Nimodipine on Alcohol Drinking Among Adults Who Are Heavy Alcohol Drinkers

Clinical trial2026-03-17Results expected Q2 2032 · ClinicalTrials.gov

Is Adding Cilostazol to Nimodipine Improving Neurological Outcome of Patients With Aneurysmal Subarachnoid Hemorrhage? A Randomized, Double Blind, Placebo-controlled Trial

Clinical trial2025-09-10Results expected Q4 2029 · ClinicalTrials.gov

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

Clinical trial2025-04-30Completed · ClinicalTrials.gov

Safety and Tolerability of GTX-104 (Nimodipine Injection for IV Infusion) Compared with Oral Nimodipine in Patients Hospitalized for Aneurysmal Subarachnoid Hemorrhage (aSAH): a Prospective, Randomized Trial

Clinical trial2024-12-01Primary completion · ClinicalTrials.gov

Cognitive Effects of Nimodipine in Patients With Schizophrenia

Clinical trial2023-05-12Completed · ClinicalTrials.gov

StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT

Clinical trial2023-04-15Completed · ClinicalTrials.gov

Stellate Ganglion Block as Adjuvant Therapy to ca Channel Blocker in Prevention of Cerebrovascular Spasm in Traumatic Subarachnoid Hemorrhage

Clinical trial2023-01-12Completed · ClinicalTrials.gov

Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.

Research1998-12-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons.

Research1995-04-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Nimodipine

Aliases & brands

NimotopNymalizeNimodipinoNimodipinumisopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylateisopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

RxNorm CUI

7426

ChEMBL ID

CHEMBL1428

ATC codes

C08CA06

UNII

57WA9QZ5WH

Primary mechanism

Mineralocorticoid receptor antagonist

Pharmacology & targets

5 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Mineralocorticoid receptor

NR3C2 · P08235

ANTAGONISTMineralocorticoid receptor antagonist

Voltage-dependent L-type calcium channel subunit alpha-1C

CACNA1C · Q13936

BLOCKERVoltage-gated L-type calcium channel blocker

Voltage-dependent L-type calcium channel subunit alpha-1S

CACNA1S · Q13698

BLOCKERVoltage-gated L-type calcium channel blocker

Voltage-dependent L-type calcium channel subunit alpha-1D

CACNA1D · Q01668

BLOCKERVoltage-gated L-type calcium channel blocker

Voltage-dependent L-type calcium channel subunit alpha-1F

CACNA1F · O60840

BLOCKERVoltage-gated L-type calcium channel blocker

Clinical trials

29 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 29

Early Phase 13Phase 14Phase 1 / 21Phase 28Phase 33Phase 45Phase N / A5

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

RCVS: The Rational Approach to Diagnosis and Treatment

WithdrawnPH IVJohns Hopkins University2019

Nimodipine for Treating Acute Massive Cerebral Infarction: a Randomized, Double-blind, Controlled Clinical Study

CompletedPH IVFengtian Hospitaln=722015

Nimodipine Preventing Cognitive Impairment in Ischemic Cerebrovascular Events: A Randomized, Placebo-Controlled, Double-Blind Trial (NICE)

Unknown statusPH IVMinistry of Science and Technology of the People´s Republic of Chinan=6562012

The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life

CompletedPH IVJanssen-Cilag Farmaceutica Ltda.n=222009

Treatment of Depression Occurring in the Setting of Cerebrovascular Risk -- A Pilot Study

TerminatedPH IVUniversity of Pittsburghn=92009

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

CompletedPH IIIKey trialUniversity of Edinburghn=1,7282025

Cognitive Effects of Nimodipine in Patients With Schizophrenia

CompletedPH IJohns Hopkins Universityn=182023

StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT

CompletedPH IIRijnstate Hospitaln=342023

Stellate Ganglion Block as Adjuvant Therapy to ca Channel Blocker in Prevention of Cerebrovascular Spasm in Traumatic Subarachnoid Hemorrhage

CompletedPH IIAssiut Universityn=402023

Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy of Oral Nimodipine and Intravenous Milrinone: Randomized Clinical Trial

CompletedPH IIZagazig Universityn=302022

A Phase 1, Randomized, Two-Period Crossover Study to Evaluate the Relative Bioavailability of Intravenous GTX-104 Compared to Oral Nimodipine Capsules at Steady State in Healthy Male and Female Subjects

CompletedPH IGrace Therapeutics Inc.n=582022

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19951998

Most influential

Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998 · 2,375 cites

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1995 · 586 cites

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Barium

Frequently co-studied with Nimodipine in the research literature.

1 shared paper

gamma-Aminobutyric Acid

Frequently co-studied with Nimodipine in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials