Drug

Oxytocin

In clinical development

ClassOxytocin receptor agonistEmerging researchLate-stage developmentRising momentum

Also known as Oxitocina, Pitocin.

RxNorm7824 ChEMBLCHEMBL395429 ATCH01BB02UNII1JQS135EYN

Research papers

Active clinical trials

Oxytocin receptor

Primary target

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Misoprostol Versus Pitocin for Induction of Labor in Patients With BMI > 30: A Randomized Controlled Trial

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Benefits of Oxytocin in OSA Patients Using CPAP

Clinical trial2026-05-04Results expected Q4 2026 · ClinicalTrials.gov

The Modulatory Effects of Oxytocin on Emotional Processing and Its Acting Routes

Clinical trial2026-04-15Primary completion · ClinicalTrials.gov

Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium

Clinical trial2026-04-06Results expected Q4 2026 · ClinicalTrials.gov

Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study

Clinical trial2026-04-06Results expected Q4 2026 · ClinicalTrials.gov

Enhancing Prolonged Exposure Therapy for PTSD With Oxytocin

Clinical trial2026-03-11Results posted · ClinicalTrials.gov

Mechanisms Underlying Oxytocin's Analgesia in Older Adults

Clinical trial2026-02-23Results posted · ClinicalTrials.gov

The Clinical Carbetocin Myocardium Trial Part 2

Clinical trial2026-02-10Results posted · ClinicalTrials.gov

G Proteins-Associated Dose-Dependent Effects of Oxytocin on Oxytocin Neuronal Activity and Astrocytic Plasticity of the Supraoptic Nucleus.

Research2025-07-22Molecular neurobiology

Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia.

Research2024-05-03The Journal of physiology

Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species.

Research2024-04-11Neuroscience and biobehavioral reviews

Social anxiety disorder-associated gut microbiota increases social fear.

Research2023-12-26Proceedings of the National Academy of Sciences of the United States of America

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Oxytocin

Aliases & brands

OxitocinaPitocin

RxNorm CUI

7824

ChEMBL ID

CHEMBL395429

ATC codes

H01BB02

UNII

1JQS135EYN

Primary mechanism

Oxytocin receptor agonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Oxytocin receptor

OXTR · P30559

AGONISTOxytocin receptor agonist

Clinical trials

194 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

194

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

125

Late-stage (III+)

129

Completed

Discontinued

PHASE DISTRIBUTIONn = 194

Early Phase 114Phase 117Phase 1 / 24Phase 234Phase 2 / 36Phase 314Phase 431Phase N / A74

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of Premature Rupture of Membranes (PROM) at Term in Nulliparous: a Randomized Controlled Trial (RUBAPRO2).

Unknown statusPH IVUniversity Hospital, Clermont-Ferrandn=5202026

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy: A Randomized Placebo-Controlled Trial

WithdrawnPH IVBeth Israel Deaconess Medical Center2025

Comparing the Effectiveness of Misoprostol, Oxytocin, Carbetocin, Vasopressin, Bupivacaine and Epinephrine, Combined IV TXA Acid and Ethamsylate and Peri Cervical Tourniquet for the Reduction of Blood Loss During of Abdominal Myomectomy.

Unknown statusPH IVCairo Universityn=1052023

POM PROM: Pitocin or Oral Misoprostol for PROM IOL in Nulliparous Women With Unfavorable Cervical Exams

CompletedPH IVUniversity of Pennsylvanian=1082023

The Efficacy and Safety of Intrauterine Misoprostol Versus Intravenous Tranexamic Acid in Reducing Blood Loss During and After Cesarean Delivery in Patients With Placenta Previa: A Randomized Controlled Trial

CompletedPH IVCairo Universityn=812023

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Randomized Controlled Trial to Test Whether Oxytocin Amplifies the Effect of Vibration to Increase Heat Pain Threshold After UV-B Burn

CompletedPH IIWake Forest University Health Sciencesn=382025

The Effect of Oxytocin on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes

CompletedN/AUniversity Hospital, Gentofte, Copenhagenn=162025

Enhancing Prolonged Exposure Therapy for PTSD With Oxytocin

CompletedPH IIVA Office of Research and Developmentn=1802025

To Compare the Mean Duration of Third Stage of Labour Between Intraumbilical and Intravenous Oxytocin.

CompletedN/ARESnTEC, Institute of Researchn=1002025

PROMMO Trial: Prelabor Rupture of Membranes Managed With Oral Misoprostol Versus Intravenous Oxytocin

CompletedPH IUniversity of Wisconsin, Madisonn=1382025

Mechanisms Underlying Oxytocin's Analgesia in Older Adults

CompletedPH II/IIIUniversity of Floridan=832024

Research activity

19 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19962025

Most influential

Oxytocin, Neural Plasticity, and Social Behavior.

Annual review of neuroscience · 2021 · 339 cites

Induction of labor compared with expectant management for prelabor rupture of the membranes at term. TERMPROM Study Group.

The New England journal of medicine · 1996 · 253 cites

Psychedelics reopen the social reward learning critical period.

Nature · 2023 · 227 cites

The Use of Oxytocin to Improve Feeding and Social Skills in Infants With Prader-Willi Syndrome.

Pediatrics · 2017 · 123 cites

Effects of single dose intranasal oxytocin on social cognition in schizophrenia.

Schizophrenia research · 2013 · 93 cites

Social anxiety disorder-associated gut microbiota increases social fear.

Proceedings of the National Academy of Sciences of the United States of America · 2024 · 52 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Dopamine

Frequently co-studied with Oxytocin in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials