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Drug

Parathyroid Hormone

Approved · EMA
ClassParathyroid hormone receptor agonistEmerging researchLate-stage developmentSteady momentum
Also known as Natpara, PTH, PTH - Parathyroid hormone, PTH(1-84)+4 more

Natpara, PTH, PTH - Parathyroid hormone, PTH(1-84), Parathormone, Parathyrin, Parathyroid hormone (1-84) human recombinant, Parathyroid hormone (rDNA).

6
Research papers
PTH1R
Primary target
2
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Market withdrawal: Natpar (EMA)

Regulatory2026-07-01EMA

Approval: Natpar (EMA)

Regulatory2017-04-24EMA

Comparison of 3 Month PTHrP(1-36) and PTH(1-34) on Post-Menopausal Osteoporosis

Clinical trial2016-03-24Results posted · ClinicalTrials.gov

Bone Properties in Hypoparathyroidism: Effects of PTH

Clinical trial2015-07-16Results posted · ClinicalTrials.gov

Can Risedronate and Parathyroid Hormone Reverse Glucocorticoid Induced Osteoporosis?

Clinical trial2015-06-25Results posted · ClinicalTrials.gov

Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS).

Research2013-04-16Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Parathyroid Hormone
Aliases & brands
NatparaPTHPTH - Parathyroid hormonePTH(1-84)ParathormoneParathyrinParathyroid hormone (1-84) human recombinantParathyroid hormone (rDNA)
RxNorm CUI
1427222
ChEMBL ID
CHEMBL2108078
ATC codes
H05AA03
UNII
N19A0T0E5J
Primary mechanism
Parathyroid hormone receptor agonist
Regulatory jurisdictions
ema

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

AGONISTParathyroid hormone receptor agonist

Regulatory timeline

2 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2017-04-24
Latest approval
2017-04-24
Authorities
EMA
Total events
2
emaEuropean Medicines Agency· 2 events
2026-07-01Market withdrawalMarket
Market withdrawal: Natpar (EMA)

Indication: Natpar is indicated as adjunctive treatment of adult patients with chronic hypoparathyroidism who cannot be adequately controlled with standard therapy alone.

Evidence ↗
2017-04-24Approval
Approval: Natpar (EMA)

Indication: Natpar is indicated as adjunctive treatment of adult patients with chronic hypoparathyroidism who cannot be adequately controlled with standard therapy alone.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

16 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
16
registered trials across all phases
LATEST COMPLETION 2017
8
Late-stage (III+)
13
Completed
3
Discontinued
PHASE DISTRIBUTIONn = 16
Early Phase 11Phase 12Phase 25Phase 2 / 32Phase 33Phase 43

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042025
Most influential
Recent papers
Major research themes4
Endocrinology1Hypoparathyroidism1Parathyroid Hormone-Related Protein1Protein-Energy Malnutrition1
Journals, researchers & institutions
Top journals
  • European journal of endocrinology1
  • Frontiers in bioscience (Landmark edition)1
  • Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA1
  • Pediatric nephrology (Berlin, Germany)1
  • The Journal of clinical endocrinology and metabolism1
  • The Journal of clinical investigation1
Leading researchers
  • Black DM2
  • Palermo L2
  • Schafer AL2
  • Sellmeyer DE2
  • Shoback DM2
  • Bakkaloglu S1
  • Bollerslev J1
  • Buch O1
Leading institutions
free-text, unnormalised
  • Aarhus University Hospital1
  • and Institute for Research and Innovation in Health of the University of Porto1
  • Aristotle University1
  • Brigham and Women's Hospital and Harvard Medical School1
  • Centre de Recherche des Cordeliers1
  • Centre de Référence des Maladies Rares du Calcium et du Phosphate1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across the same disease area as Parathyroid Hormone in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.