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Drug

Vitamin D

In clinical development
ClassVitamin D receptor agonistActively researchedLate-stage developmentCooling momentum
Also known as Calciferol, Calciotropic hormone, D Vitamin, Vit.D+4 more

Calciferol, Calciotropic hormone, D Vitamin, Vit.D, Vitamin D NOS, Vitamin D, unspecified form, Vitamin-D, Vitamin D and/or vitamin D derivative.

40
Research papers
15
Active clinical trials
Vitamin D3 receptor
Primary target
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Study challenges a common belief about vitamin D and sunlight

Research2026-06-24Research news · Science Daily

Study challenges a common belief about vitamin D and sunlight

Research2026-06-24Research news · Science Daily

Vitamin D Treatment in IntraCerebal Hemorrhage To Enhance Hematoma Resolution (VICToHR): a Pilot Study

Clinical trial2026-05-06Results expected Q3 2027 · ClinicalTrials.gov

Regime for Vitamin D Maintenance in Post-Operative Patients (D-ECISIVE) Randomized Controlled Trial

Clinical trial2026-05-04Results expected Q4 2026 · ClinicalTrials.gov

Molecular Insight into the Role of Vitamin D in Immune-Mediated Inflammatory Diseases.

Research2025-05-16International journal of molecular sciences

Evidence confidence

1 claim

How strongly the incorporated evidence supports specific clinical claims about this treatment. A confidence figure is a current summary of evidence strength, not a permanent verdict.

Improves depressive symptoms in adults
9%Very low confidence
Uncertainty ±28%Evidence coverage: PartialUpdated 31 December 2025

High point estimate, but substantial uncertainty remains.

Evidence is mixed1 supporting evidence family · 1 well-powered no-effect result

Confidence is moderated by well-powered no-effect evidence and limited publication incorporation.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Vitamin D
Aliases & brands
CalciferolCalciotropic hormoneD VitaminVit.DVitamin D NOSVitamin D, unspecified formVitamin-DVitamin D and/or vitamin D derivative
RxNorm CUI
11253
ChEMBL ID
CHEMBL1536
ATC codes
A11CC01
UNII
9VU1KI44GP
Primary mechanism
Vitamin D receptor agonist

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Vitamin D3 receptor
VDR · P11473
AGONISTVitamin D receptor agonist

Clinical trials

189 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
189
registered trials across all phases
LATEST COMPLETION 2025
15
Active studies
13
Recruiting
139
Late-stage (III+)
122
Completed
52
Discontinued
PHASE DISTRIBUTIONn = 189
Early Phase 19Phase 110Phase 1 / 25Phase 226Phase 2 / 35Phase 334Phase 442Phase N / A58

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

40 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20042025
Most influential

The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022 · 801 cites

Resurrection of vitamin D deficiency and rickets.

The Journal of clinical investigation · 2006 · 800 cites
Recent papers
Major research themes8
Vitamin D9Vitamin D Deficiency5Dietary Supplements4Melanoma3Receptors, Calcitriol3Skin Neoplasms3Autoimmune Diseases2Betacoronavirus2
Journals, researchers & institutions
Top journals
  • Nutrients10
  • International journal of molecular sciences7
  • Frontiers in endocrinology2
  • The Journal of clinical investigation2
  • Acta dermato-venereologica1
  • Andrology1
Leading researchers
  • Bechter O3
  • Bennett GG3
  • Boecxstaens V3
  • Bogaerts K3
  • Chan AT3
  • Chandler PD3
  • De Smedt J3
  • Drake BF3
Leading institutions
free-text, unnormalised
  • Brigham and Women's Hospital3
  • Clinical and Experimental Endocrinology2
  • College of Human Ecology2
  • Conway Institute of Biomolecular and Biomedical Research2
  • Laboratory for Translational Genetics2
  • Laboratory of Dermatology2

Related diseases

12 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Acts on the same molecular target as Vitamin D, with 9 overlapping disease areas.

Shared target9 shared diseases3 shared papers

Studied across 17 of the same disease areas as Vitamin D in the shared literature.

17 shared diseases2 shared papers

Studied across 17 of the same disease areas as Vitamin D in the shared literature.

17 shared diseases1 shared paper

Studied across 12 of the same disease areas as Vitamin D in the shared literature.

12 shared diseases2 shared papers

Studied across 14 of the same disease areas as Vitamin D in the shared literature.

14 shared diseases1 shared paper

Studied across 11 of the same disease areas as Vitamin D in the shared literature.

11 shared diseases1 shared paper

Studied across 7 of the same disease areas as Vitamin D in the shared literature.

7 shared diseases1 shared paper

Studied across 7 of the same disease areas as Vitamin D in the shared literature.

7 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials