Back to discover
Drug

Sodium Chloride

Approved · FDA
Emerging researchLate-stage developmentRising momentum
Also known as Adsorbonac, Altamist, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free+104 more

Adsorbonac, Altamist, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Ayr Saline Nasal, BSS Ophthalmic Solution, Breathe Free Saline, Broncho Saline, Cleanoz Saline, Cloruro sódico, Colyte, Common salt, Deep Sea, Dextrose 5% and Plasma-Lyte 148, ENTsol, Endosol Extra, Extraneal, GaviLyte-C, GaviLyte-G, GaviLyte-N, Gavilyte-H, Gentran 70, GoLYTELY, Humist, Hydra-Neb, Hyper-Sal, Isolyte S, Isolyte S and 5% Dextrose, Isolyte S in 5 % Dextrose, Little Noses, Macrodex, Marine Mist, MoviPrep, Muro 128, Mycinaire, NACl, Na-zone, Nasadrops, Nasal Moist, Natriumchlorid, Natrum muriaticum, Navstel, NebuSal, Nephramine, Normosol-M, Normosol-R, Normosol-R PH 7.4, Normosol-R and 5% Dextrose, Normosol-R in 5 % Dextrose, NuLYTELY, NuLYTELY Cherry, NuLYTELY Lemon Lime, NuLYTELY Orange, Nutrilyte II, Ocean, Pediamist, Physiolyte, Physiosol, Plasma-Lyte, Plasma-Lyte 148, Plasma-Lyte 56, Plasma-Lyte 56 and 5% Dextrose, Plasma-Lyte 56 in 5 % Dextrose, Plasmalyte A, Pretz, ProcalAmine 3, PulmoSal, Regiocit, Rhinaris, Rhinomel, Salinex, Saljet, SaltAire, Sea Mist Nasal Spray, Sea Soft, Simply Saline, Sinucleanse, Sochlor, Thermotabs, Tis-U-Sol, TriLyte, Trophamine, Trophamine 10 %, Trophamine 6 %, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25, Dextran In Sodium Chloride, Dextrose/Potassium Chloride/Sodium Chloride, Dianeal Low Calcium 1.5, Dianeal Low Calcium 2.5, Dianeal Low Calcium 4.25, Dianeal PD-2/1.5, Dianeal PD-2/2.5, Dianeal PD-2/4.25, NaCl - Sodium chloride, Ocean brand of sodium chloride, Potassium Chloride in Sodium Chloride, Potassium Chloride-Sodium Chloride, Sodium Chloride Irrigation, Sodium Chloride, Injectable, Sodium chloride solution, Sodium-chloride, natrium chloride.

5
Research papers
34
Active clinical trials
50
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Impact of Dietary Salt on the Severity of Eczema

Clinical trial2026-06-09Results expected Q1 2028 · ClinicalTrials.gov

Recall (Class II): SODIUM CHLORIDE

Regulatory2025-08-04FDA

Neuronal sensorimotor integration guiding salt concentration navigation in <i>Caenorhabditis elegans</i>.

Research2024-01-22Proceedings of the National Academy of Sciences of the United States of America

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Sodium Chloride
Aliases & brands
AdsorbonacAltamistAminosyn 3.5 % M, Sulfite FreeAminosyn 8.5 % with Electrolytes, Sulfite-FreeAminosyn II 8.5 % with Electrolytes, Sulfite-FreeAyr Saline NasalBSS Ophthalmic SolutionBreathe Free SalineBroncho SalineCleanoz SalineCloruro sódicoColyteCommon saltDeep SeaDextrose 5% and Plasma-Lyte 148ENTsolEndosol ExtraExtranealGaviLyte-CGaviLyte-GGaviLyte-NGavilyte-HGentran 70GoLYTELYHumistHydra-NebHyper-SalIsolyte SIsolyte S and 5% DextroseIsolyte S in 5 % DextroseLittle NosesMacrodexMarine MistMoviPrepMuro 128MycinaireNAClNa-zoneNasadropsNasal MoistNatriumchloridNatrum muriaticumNavstelNebuSalNephramineNormosol-MNormosol-RNormosol-R PH 7.4Normosol-R and 5% DextroseNormosol-R in 5 % DextroseNuLYTELYNuLYTELY CherryNuLYTELY Lemon LimeNuLYTELY OrangeNutrilyte IIOceanPediamistPhysiolytePhysiosolPlasma-LytePlasma-Lyte 148Plasma-Lyte 56Plasma-Lyte 56 and 5% DextrosePlasma-Lyte 56 in 5 % DextrosePlasmalyte APretzProcalAmine 3PulmoSalRegiocitRhinarisRhinomelSalinexSaljetSaltAireSea Mist Nasal SpraySea SoftSimply SalineSinucleanseSochlorThermotabsTis-U-SolTriLyteTrophamineTrophamine 10 %Trophamine 6 %Clinimix E 2.75/5Clinimix E 4.25/10Clinimix E 4.25/5Clinimix E 5/15Clinimix E 5/20Clinimix E 5/25Dextran In Sodium ChlorideDextrose/Potassium Chloride/Sodium ChlorideDianeal Low Calcium 1.5Dianeal Low Calcium 2.5Dianeal Low Calcium 4.25Dianeal PD-2/1.5Dianeal PD-2/2.5Dianeal PD-2/4.25NaCl - Sodium chlorideOcean brand of sodium chloridePotassium Chloride in Sodium ChloridePotassium Chloride-Sodium ChlorideSodium Chloride IrrigationSodium Chloride, InjectableSodium chloride solutionSodium-chloridenatrium chloride
RxNorm CUI
9863
ChEMBL ID
CHEMBL1200574
ATC codes
A12CA01S01XA03B05CB01B05XA03
UNII
451W47IQ8X
Regulatory jurisdictions
fda

Regulatory timeline

50 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
1979-02-02
Latest approval
2005-08-26
Authorities
FDA
Total events
50
fdaU.S. Food and Drug Administration· 50 events
2025-08-04RecallSafety
Recall (Class II): SODIUM CHLORIDE
Evidence ↗
2024-07-24Label change
Label change: SODIUM CHLORIDE (NDA018016)
Evidence ↗
2019-05-29Label change
Label change: SODIUM CHLORIDE (NDA018016)
Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

196 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
196
registered trials across all phases
LATEST COMPLETION 2026
34
Active studies
29
Recruiting
132
Late-stage (III+)
112
Completed
50
Discontinued
PHASE DISTRIBUTIONn = 196
Early Phase 13Phase 127Phase 1 / 24Phase 230Phase 2 / 37Phase 333Phase 454Phase N / A38

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

5 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20072024
Most influential
Recent papers
Major research themes8
Air Movements1Air Pollutants1Antioxidants1Exhalation1Models, Theoretical1Nervous System Physiological Phenomena1Saccharomyces cerevisiae1Saccharomyces cerevisiae Proteins1
Journals, researchers & institutions
Top journals
  • G3 (Bethesda, Md.)1
  • Indoor air1
  • Journal of clinical medicine1
  • Proceedings of the National Academy of Sciences of the United States of America1
  • Scientific reports1
Leading researchers
  • Ali Q1
  • Ashfaq M1
  • Bara Ledesma N1
  • Blázquez Sánchez J1
  • Cai R1
  • Chwang AT1
  • Escobar Cervantes C1
  • Fabregate M1
Leading institutions
free-text, unnormalised
  • Center for Genomic Science Innovation1
  • College of Science and Engineering1
  • Graduate School of Science1
  • Great Lakes Bioenergy Research Center1
  • Hospital Universitario La Paz1
  • Hospital Universitario Ramón y Cajal1

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 3 of the same disease areas as Sodium Chloride in the shared literature.

3 shared diseases1 shared paper

Frequently co-studied with Sodium Chloride in the research literature.

1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.