Drug

Water

Approved medicine

ResearchActive indication expansion

Also known as AQUA, Dihydrogen oxide, Eye Stream, H2O - water+5 more

AQUA, Dihydrogen oxide, Eye Stream, H2O - water, OcuFresh, Opticlear, Pur-Wash, Water, Sterile, agua.

RxNorm11295 ChEMBLCHEMBL1098659UNII059QF0KO0R

Research papers

Active clinical trials

Regulatory events

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Approval: INSULIN ASPART-FSAN (BLA761497)

Regulatory2026-07-24FDA

Racecadotril for Organ Injury in Sepsis Patients: A Single-Center, Single-Blind, Randomized, Placebo-Controlled Pilot Trial

Clinical trial2026-05-28Results expected Q4 2027 · ClinicalTrials.gov

If the Use of Epsom Salt (magnesium Sulfate) Compresses 25% Effective in Relieving Perineal Pain in Immediate Postpartum Patients?

Clinical trial2025-12-15Primary completion · ClinicalTrials.gov

Effect of Preoperative Two Hours Carbohydrate Load On Pediatric Patient Undergoing Elective Surgery: A Randomized Controlled Study

Clinical trial2024-10-21Completed · ClinicalTrials.gov

Effect of Topical Application of Hypertonic Saline on Melanoma on Its Sizes and Number.

Clinical trial2024-02-29Primary completion · ClinicalTrials.gov

Coral thermal stress and bleaching enrich and restructure reef microbial communities via altered organic matter exudation.

Research2024-02-13Communications biology

The Effect of Oral Sprays on Salivary pH Changes After Coca-cola Consumption

Clinical trial2024-01-25Completed · ClinicalTrials.gov

Pink1 deficiency enhances neurological deficits and inflammatory responses after intracerebral hemorrhage in mice.

Research2024-01-23Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures.

Research2023-12-21Fluids and barriers of the CNS

Microbial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere.

Research2023-11-01Microbiome

The combined effects of ultrasound and plasma-activated water on microbial inactivation and quality attributes of crayfish during refrigerated storage.

Research2023-07-12Ultrasonics sonochemistry

A Randomized, Placebo Controlled, Double Blind, Single and Repeat Dose Escalation Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of GSK3915393 in Healthy Participants and Open Label Assessment of Coadministration of GSK3915393 With Grapefruit Juice and Itraconazole on the Pharmacokinetics of GSK3915393

Clinical trial2023-05-09Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Water

Aliases & brands

AQUADihydrogen oxideEye StreamH2O - waterOcuFreshOpticlearPur-WashWater, Sterileagua

RxNorm CUI

11295

ChEMBL ID

CHEMBL1098659

UNII

059QF0KO0R

Regulatory jurisdictions

fda

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval

2026-07-24

Latest approval

2026-07-24

Authorities

FDA

Total events

fdaU.S. Food and Drug Administration· 1 event

2026-07-24Approval

Approval: INSULIN ASPART-FSAN (BLA761497)

Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

51 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2024

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 51

Early Phase 12Phase 18Phase 1 / 21Phase 26Phase 2 / 32Phase 36Phase 411Phase N / A15

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Effect of Oral Sprays on Salivary pH Changes After Coca-cola Consumption

CompletedPH IVI.M. Sechenov First Moscow State Medical Universityn=332024

Effects of Chenodeoxycholic Acid and Colesevelam on GLP-1 Secretion, During a Meal, After Roux-en-Y Gastric Bypass

CompletedPH IVHvidovre University Hospitaln=122020

Essential Oils With and Without Alcohol: in Vivo Antibacterial Effect

Unknown statusPH IVUniversity of Santiago de Compostelan=202017

Clinical Trial of Pinverin (Pinaverium Bromide) to Reduce Bowel Uptake of FDG in a Variety of Cancer Patients Who Undergo FDG PET/CT

CompletedPH IVSeoul National University Hospitaln=582015

The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study

CompletedPH IVUniversity of Oslon=592015

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effect of Preoperative Two Hours Carbohydrate Load On Pediatric Patient Undergoing Elective Surgery: A Randomized Controlled Study

CompletedN/ATanta Universityn=902024

The Effect of Oral Sprays on Salivary pH Changes After Coca-cola Consumption

CompletedPH IVI.M. Sechenov First Moscow State Medical Universityn=332024

Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

CompletedN/AKey trialGuangzhou Blood Centern=6,2502021

CompletedPH IGlaxoSmithKlinen=652021

Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - V: A Double-Blind Randomized Controlled Trial

CompletedN/AIndonesia Universityn=342021

Effects of Chenodeoxycholic Acid and Colesevelam on GLP-1 Secretion, During a Meal, After Roux-en-Y Gastric Bypass

CompletedPH IVHvidovre University Hospitaln=122020

Research activity

10 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20072024

Most influential

The physiology of plant responses to drought.

Science (New York, N.Y.) · 2020 · 1,093 cites

How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve.

Indoor air · 2007 · 497 cites

Laccases: structure, function, and potential application in water bioremediation.

Microbial cell factories · 2019 · 221 cites

Aridity-driven shift in biodiversity-soil multifunctionality relationships.

Nature communications · 2021 · 217 cites

Water insecurity and urban poverty in the Global South: Implications for health and human biology.

American journal of human biology : the official journal of the Human Biology Council · 2020 · 39 cites

Microbial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere.

Microbiome · 2023 · 35 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Sodium Chloride

Studied across 3 of the same disease areas as Water in the shared literature.

3 shared diseases1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials
Regulatory event sources are credited in the Regulatory Timeline above.