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Drug

Tipiracil

In clinical development
Emerging researchEarly-to-mid development

Also known as Lonsurf, Tipiracilo, 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione.

1
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Tipiracil
Aliases & brands
LonsurfTipiracilo5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione
RxNorm CUI
1670304
ChEMBL ID
CHEMBL235668
UNII
NGO10K751P

Clinical trials

1 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
1
registered trials across all phases
1
Discontinued
PHASE DISTRIBUTIONn = 1
Phase 21

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer.

The New England journal of medicine · 2023 · 313 cites
Recent papers

Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer.

The New England journal of medicine · 2023 · 313 cites
Major research themes3
Colonic Neoplasms1Colorectal Neoplasms1Rectal Neoplasms1
Journals, researchers & institutions
Top journals
  • The New England journal of medicine1
Leading researchers
  • Amellal N1
  • Benhadji KA1
  • Bondarenko I1
  • Ciardiello F1
  • Cremolini C1
  • Cruz FM1
  • Elez E1
  • Fakih M1
Leading institutions
free-text, unnormalised
  • Comprehensive Cancer Center1

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 3 of the same disease areas as Tipiracil in the shared literature.

3 shared diseases1 shared paper

Studied across 3 of the same disease areas as Tipiracil in the shared literature.

3 shared diseases1 shared paper

Studied across 3 of the same disease areas as Tipiracil in the shared literature.

3 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials