Drug

Tranilast

In clinical development

Emerging researchLate-stage development

Also known as N-(3,4-Dimethoxycinnamoyl)anthranilic acid, Tranilastum.

RxNorm57330 ChEMBLCHEMBL415324UNIIHVF50SMY6E

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Study on the Effectiveness of Tranilast in the Treatment of Medium to Large Volume Benign Prostatic Hyperplasia

Clinical trial2026-01-08Results expected Q4 2026 · ClinicalTrials.gov

Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) Following Circumferential Endoscopic Submucosal Dissection (cESD) for Superficial Neoplasms

Clinical trial2024-11-14Results expected Q4 2027 · ClinicalTrials.gov

Application of Tranilast as a Radiosensitizer in the Treatment of Radiotherapy Resistant Nasopharyngeal Carcinoma: a Phase II Clinical Study

Clinical trial2024-07-20Primary completion · ClinicalTrials.gov

Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea

Clinical trial2024-06-01Primary completion · ClinicalTrials.gov

Efficacy and Safety of Tranilast in Patients With Cryopyrin-Associated Periodic Syndrome (CAPS): A Single-Arm Prospective Cohort Study

Clinical trial2024-04-01Primary completion · ClinicalTrials.gov

Effect of Inflammasome Inhibitor on High-sensitivity C-reactive Protein in Patients After Percutaneous Coronary Intervention

Clinical trial2023-02-01Completed · ClinicalTrials.gov

A Clinical Study of Tranilast in the Treatment of Mucinoses

Clinical trial2022-06-01Primary completion · ClinicalTrials.gov

A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum

Clinical trial2020-06-01Primary completion · ClinicalTrials.gov

A Clinical Study of Tranilast in the Treatment of Sarcoidosis

Clinical trial2020-05-01Primary completion · ClinicalTrials.gov

Pharmacological Inhibitors of the NLRP3 Inflammasome.

Research2019-10-25Frontiers in immunology

A Phase II, Randomized Multi-Center, Double-Blind Study of Tranilast With Concomitant Methotrexate (MTX) Compared to MTX Alone in Patients With Active Rheumatoid Arthritis (RA)

Clinical trial2010-12-01Completed · ClinicalTrials.gov

A Randomized, Double-Blind, Crossover, Pharmacodynamic and Pharmacokinetic Drug Interaction Study of Tranilast in Combination With Allopurinol Compared With Tranilast Alone and Allopurinol Alone in Healthy Subjects With Hyperuricemia

Clinical trial2010-11-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Tranilast

Aliases & brands

N-(3,4-Dimethoxycinnamoyl)anthranilic acidTranilastum

RxNorm CUI

57330

ChEMBL ID

CHEMBL415324

UNII

HVF50SMY6E

Clinical trials

13 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2023

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 13

Early Phase 14Phase 11Phase 26Phase 42

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea

Unknown statusPH IVSecond Affiliated Hospital of Xi'an Jiaotong Universityn=452024

Effect of Inflammasome Inhibitor on High-sensitivity C-reactive Protein in Patients After Percutaneous Coronary Intervention

CompletedPH IVUnion Hospital, Tongji Medical College, Huazhong University of Science and Technologyn=1322023

Recent completions

Trials that read out recently, adding to the completed evidence base.

Effect of Inflammasome Inhibitor on High-sensitivity C-reactive Protein in Patients After Percutaneous Coronary Intervention

CompletedPH IVUnion Hospital, Tongji Medical College, Huazhong University of Science and Technologyn=1322023

A Phase II, Randomized Multi-Center, Double-Blind Study of Tranilast With Concomitant Methotrexate (MTX) Compared to MTX Alone in Patients With Active Rheumatoid Arthritis (RA)

CompletedPH IINuon Therapeutics, Inc.n=2502010

CompletedPH IINuon Therapeutics, Inc.n=242010

A Randomized, Double-Blind, Crossover, Pharmacodynamic and Pharmacokinetic Drug Interaction Study of Tranilast in Combination With Febuxostat Compared With Tranilast Alone and Febuxostat Alone in Healthy Subjects With Hyperuricemia

CompletedPH IINuon Therapeutics, Inc.n=242010

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Pharmacological Inhibitors of the NLRP3 Inflammasome.

Frontiers in immunology · 2019 · 518 cites

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Belnacasan

Frequently co-studied with Tranilast in the research literature.

1 shared paper

Glyburide

Frequently co-studied with Tranilast in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials