Drug

Tranylcypromine

In clinical development

Emerging researchLate-stage development

Also known as (1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamine, Parnate, Racemic Tranylcypromine+7 more

(1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamine, Parnate, Racemic Tranylcypromine, dl-tranylcypromine, trans-2-phenylcyclopropylamine, trans-DL-2-Phenylcyclopropylamine, Tranilcipromina, Tranylcypromin, Tranylcypromine Sulfate, Tranylcyprominum.

RxNorm10734 ChEMBLCHEMBL1179UNII3E3V44J4Z9

Research papers

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Phase I/II Study of Sensitization of Non-M3 Acute Myeloid Leukemia (AML) Blasts to All-trans Retinoic Acid (ATRA) by Epigenetic Treatment With Tranylcypromine (TCP), an Inhibitor of the Histone Lysine Demethylase 1 (LSD1)

Clinical trial2020-12-01Primary completion · ClinicalTrials.gov

A Phase 1 Dose Escalation Study of Tranylcypromine (TCP) in Combination With ATRA (Tretinoin) for Adult Patients With Relapsed/Refractory Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndromes (MDS)

Clinical trial2020-07-01Completed · ClinicalTrials.gov

Tranylcypromine Treatment of Bipolar Depression

Clinical trial2018-03-15Results posted · ClinicalTrials.gov

Phase I/II Pilot Trial of ATRA (Tretinoin) and TCP (Tranylcypromine) in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) and no Intensive Treatment is Possible

Clinical trial2017-09-01Primary completion · ClinicalTrials.gov

Pharmacovigilance in Gerontopsychiatric Patients

Clinical trial2017-06-28Terminated · ClinicalTrials.gov

Evaluation and Treatment of Autonomic Failure.

Clinical trial2017-01-01Completed · ClinicalTrials.gov

Efficacy of Interpersonal Psychotherapy in Treatment Resistant Depression

Clinical trial2014-08-01Primary completion · ClinicalTrials.gov

Developing a Biomarker to Predict Response in Treatment Resistant Depression

Clinical trial2013-03-01Terminated · ClinicalTrials.gov

Sequenced Treatment Alternatives to Relieve Depression

Clinical trial2006-09-01Completed · ClinicalTrials.gov

A Pilot Study of Treatment for Refractory Depression With Sequential Trials of Tranylcypromine, Tranylcypromine Plus Dextroamphetamine, Tranylcypromine Plus Triiodothyronine.

Clinical trial2006-08-01Terminated · ClinicalTrials.gov

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Clinical trial2005-09-01Completed · ClinicalTrials.gov

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.

Research2000-12-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Tranylcypromine

Aliases & brands

(1R*,2S*)-2-phenylcyclopropan-1-amine(±)-trans-2-phenylcyclopropylamineParnateRacemic Tranylcyprominedl-tranylcyprominetrans-2-phenylcyclopropylaminetrans-DL-2-PhenylcyclopropylamineTranilciprominaTranylcyprominTranylcypromine SulfateTranylcyprominum

RxNorm CUI

10734

ChEMBL ID

CHEMBL1179

UNII

3E3V44J4Z9

Clinical trials

13 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2020

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 13

Phase 13Phase 1 / 22Phase 31Phase 45Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Tranylcypromine Treatment of Bipolar Depression

CompletedPH IVNew York State Psychiatric Instituten=72014

Developing a Biomarker to Predict Response in Treatment Resistant Depression

TerminatedPH IVNew York State Psychiatric Instituten=132013

Sequenced Treatment Alternatives to Relieve Depression

CompletedPH IVKey trialNational Institute of Mental Health (NIMH)n=4,0002006

A Pilot Study of Treatment for Refractory Depression With Sequential Trials of Tranylcypromine, Tranylcypromine Plus Dextroamphetamine, Tranylcypromine Plus Triiodothyronine.

TerminatedPH IVNew York State Psychiatric Instituten=312006

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

CompletedPH IVUniversity of Pittsburghn=602004

Recent completions

Trials that read out recently, adding to the completed evidence base.

CompletedPH IUniversity of Miamin=172020

Evaluation and Treatment of Autonomic Failure.

CompletedPH IVanderbilt Universityn=3892017

Tranylcypromine Treatment of Bipolar Depression

CompletedPH IVNew York State Psychiatric Instituten=72014

Sequenced Treatment Alternatives to Relieve Depression

CompletedPH IVKey trialNational Institute of Mental Health (NIMH)n=4,0002006

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

CompletedN/AKey trialNational Institute of Mental Health (NIMH)n=5,0002005

To Compare Bioavailability of Kali Tranylcypromine 10mg Tablets to That of Parnate 10 mg Tablets Under Fasting Conditions.

CompletedPH IPar Pharmaceutical, Inc.n=392004

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000 · 2,294 cites

Related drugs

3 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Bromodeoxyuridine

Frequently co-studied with Tranylcypromine in the research literature.

1 shared paper

Fluoxetine

Frequently co-studied with Tranylcypromine in the research literature.

1 shared paper

Reboxetine

Frequently co-studied with Tranylcypromine in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials