Drug

Vitamin E

In clinical development

Emerging researchLate-stage developmentSteady momentum

Also known as Amino-Opti-E, Aquasol E, Aquavite-E, Encora Capsule+31 more

Amino-Opti-E, Aquasol E, Aquavite-E, Encora Capsule, Hemax, Lactocal, Lazer Creme, LiQ-10, MVC-Fluoride, Macuvite with Lutein, Multi-Delyn, NeoQ10, Ocuvite, Ocuvite Lutein, Poly-Vi-Sol, Poly-Vi-Sol with Iron, Prenatal Rx 1, PreserVision, PreserVision with Lutein, Q-Gel, Q-Gel with Lipoic Acid, Q-Up, Replesta NX, Sea-Omega, Vitafol-One, Vitamin E (Tocopherol), Vitamin E D-Alpha, Vitamin E DL-Alpha, Vitamin E Oil, Vitamin E Topical, tocopherol, tocopherol (vit E), 5,7,8-trimethyltocol, Vitamin E Succinate, Vitamin E and/or vitamin E derivative.

RxNorm11256 ChEMBLCHEMBL47UNIIN9PR3490H9

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Chiglitazar in Combination With Anti-Inflammatory and Hepatoprotective Therapy for the Treatment in MASH Associated With T2DM: a Prospective, Multicentre, Randomised, Double-blind, Placebo-controlled Study

Clinical trial2026-06-03Results expected Q4 2030 · ClinicalTrials.gov

The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections - Randomized Controlled Trial

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Vitamin E Dosing Study (VEDS): A Dose Finding Study of Vitamin E for the Treatment of Adult NAFLD

Clinical trial2026-05-14Results posted · ClinicalTrials.gov

Comparison of Vitamin E in Combination With Mefenamic Acid Versus Mefenamic Acid Alone for Management of Primary Dysmenorrhea

Clinical trial2026-01-14Completed · ClinicalTrials.gov

Phase II Clinical Study of Vitamin E Combined With Fruquintinib and Tislelizumab in Patients With Microsatellite Stabilized Metastatic Colorectal Cancer Who Failed Standard Therapy

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review).

Research2025-05-09Molecular medicine reports

Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

Clinical trial2025-03-01Completed · ClinicalTrials.gov

Open-label Randomized Controlled Trial for the Effects of Continuous Ethinylestradiol/Levonorgestrel (30/150 μg/Day) Compared With Vitamin E (400 IU/Day) in the Treatment of Menstrually-related Migraine and Migraine During Perimenopause

Clinical trial2024-12-01Primary completion · ClinicalTrials.gov

Efficacy and Safety of Roflumilast in Patients with Non-Alcoholic Steatohepatitis

Clinical trial2024-10-15Completed · ClinicalTrials.gov

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.

Research2022-03-14BMC endocrine disorders

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators.

Research2019-10-08International journal of molecular sciences

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Research2001-10-01Archives of ophthalmology (Chicago, Ill. : 1960)

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Vitamin E

Aliases & brands

Amino-Opti-EAquasol EAquavite-EEncora CapsuleHemaxLactocalLazer CremeLiQ-10MVC-FluorideMacuvite with LuteinMulti-DelynNeoQ10OcuviteOcuvite LuteinPoly-Vi-SolPoly-Vi-Sol with IronPrenatal Rx 1PreserVisionPreserVision with LuteinQ-GelQ-Gel with Lipoic AcidQ-UpReplesta NXSea-OmegaVitafol-OneVitamin E (Tocopherol)Vitamin E D-AlphaVitamin E DL-AlphaVitamin E OilVitamin E Topicaltocopheroltocopherol (vit E)5,7,8-trimethyltocolVitamin E SuccinateVitamin E and/or vitamin E derivative

RxNorm CUI

11256

ChEMBL ID

CHEMBL47

UNII

N9PR3490H9

Clinical trials

80 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2026

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 80

Phase 17Phase 1 / 23Phase 221Phase 2 / 34Phase 327Phase 411Phase N / A7

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections - Randomized Controlled Trial

Not yet recruitingPH IVAssiut Universityn=2602026

Comparison of Vitamin E in Combination With Mefenamic Acid Versus Mefenamic Acid Alone for Management of Primary Dysmenorrhea

CompletedPH IVNishtar Medical Universityn=602026

Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

CompletedPH IVTanta Universityn=602025

Endothelial Monocyte-activating Polypeptide-II as an Endothelial Dysfunction Marker and Its Relation to the Oxidative Stress in Egyptian Sickle Patients

CompletedPH IVAin Shams Universityn=502023

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block on Patients With Symptomatic Irreversible Pulpitis: a Double Blinded, Randomized Controlled Trial.

CompletedPH IVFarjad Zafarn=1202022

Recent completions

Trials that read out recently, adding to the completed evidence base.

Comparison of Vitamin E in Combination With Mefenamic Acid Versus Mefenamic Acid Alone for Management of Primary Dysmenorrhea

CompletedPH IVNishtar Medical Universityn=602026

Vitamin E Dosing Study (VEDS): A Dose Finding Study of Vitamin E for the Treatment of Adult NAFLD

CompletedPH IINational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)n=2002025

Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

CompletedPH IVTanta Universityn=602025

Efficacy and Safety of Roflumilast in Patients with Non-Alcoholic Steatohepatitis

CompletedPH IITanta Universityn=552024

Effectiveness of Obeticholic Acid Versus Vitamin E in Patients of Non-alcoholic Fatty Liver Disease

CompletedPH IIKing Edward Medical Universityn=902024

Role of Vitamin E as an Adjuvant Therapy for Patients With Gaucher Disease Under Enzyme Replacement Therapy in Relation to Oxidative Stress

CompletedPH IIIAin Shams Universityn=402023

Research activity

5 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

19972025

Most influential

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Archives of ophthalmology (Chicago, Ill. : 1960) · 2001 · 1,978 cites

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

The New England journal of medicine · 1997 · 1,344 cites

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.

BMC endocrine disorders · 2022 · 549 cites

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators.

International journal of molecular sciences · 2019 · 468 cites

The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review).

Molecular medicine reports · 2025 · 3 cites

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Alzheimer's Disease2

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Ascorbic Acid

Studied across 2 of the same disease areas as Vitamin E in the shared literature.

2 shared diseases1 shared paper

beta Carotene

Studied across 2 of the same disease areas as Vitamin E in the shared literature.

2 shared diseases1 shared paper

Selegiline

Studied across the same disease area as Vitamin E in the shared literature.

1 shared disease1 shared paper

Hydrogen Peroxide

Frequently co-studied with Vitamin E in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials