ABCB11

Gene

ATP binding cassette subfamily B member 11

HGNCHGNC:42 EnsemblENSG00000073734 NCBI Gene8647

Locus: gene with protein productLocation: 2q31.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBSEP · PFIC2 · ABC16 · SPGP · PFIC-2 · PGY4

View full nomenclature history (10)

Previous symbolsBSEP, PFIC2

Alias symbolsABC16, SPGP, PFIC-2, PGY4

Previous namesprogressive familial intrahepatic cholestasis 2, bile salt export pump, ATP-binding cassette, sub-family B (MDR/TAP), member 11

Alias namesABC member 16, MDR/TAP subfamily

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Progressive familial intrahepatic cholestasis

Cholestasis, Intrahepatic

Progressive familial intrahepatic cholestasis type 1

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATP binding cassette subfamily B

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.