Progressive familial intrahepatic cholestasis type 1
Also known as Byler disease, FIC1 deficiency, PFIC1, cholestasis, progressive familial intrahepatic 1+6 more
Byler disease, FIC1 deficiency, PFIC1, cholestasis, progressive familial intrahepatic 1, cholestasis, progressive familial intrahepatic, type 1, Byler's disease, cholestasis, fatal intrahepatic, cholestasis, progressive familial intrahepatic, 1, progressive familial intrahepatic cholestasis, severe ATP8B1 deficiency.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Therapeutic landscape
Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.
Approval — Livmarli is indicated for the treatment of: Cholestatic pruritus in patients with Alagil… (2022)
Accelerated approval — Bylvay is indicated for the treatment of progressive familial intrahepatic cholestasis (P… (2021)
Regulatory timeline
Drug regulatory events matched to this condition by indication — EMA.
European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Byler disease, FIC1 deficiency, PFIC1, cholestasis, progressive familial intrahepatic 1, cholestasis, progressive familial intrahepatic, type 1, Byler's disease, cholestasis, fatal intrahepatic, cholestasis, progressive familial intrahepatic, 1, progressive familial intrahepatic cholestasis, severe ATP8B1 deficiency
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Related entities are derived from literature co-mention (studied together) — associative, not causal.